| Literature DB >> 35617386 |
Yeon Sik Choi1,2,3, Hyoyoung Jeong1,2, Rose T Yin4, Raudel Avila5, Anna Pfenniger6, Jaeyoung Yoo1,2, Jong Yoon Lee1,2,7, Andreas Tzavelis1,2,8,9, Young Joong Lee1,2, Sheena W Chen10,11, Helen S Knight4, Seungyeob Kim1,2,12, Hak-Young Ahn1,2,3, Grace Wickerson1,2,13, Abraham Vázquez-Guardado1,2, Elizabeth Higbee-Dempsey14, Bender A Russo4, Michael A Napolitano10,11, Timothy J Holleran10,11, Leen Abdul Razzak1,2,8, Alana N Miniovich4, Geumbee Lee1,2, Beth Geist6, Brandon Kim7, Shuling Han15,16, Jaclyn A Brennan4, Kedar Aras4, Sung Soo Kwak1,2, Joohee Kim1,2, Emily Alexandria Waters8,17, Xiangxing Yang18, Amy Burrell6, Keum San Chun18, Claire Liu1,2,8, Changsheng Wu1,2, Alina Y Rwei19, Alisha N Spann17, Anthony Banks1,2, David Johnson6, Zheng Jenny Zhang15,16, Chad R Haney8,17, Sung Hun Jin1,2,12, Alan Varteres Sahakian8,20, Yonggang Huang1,3,5,21, Gregory D Trachiotis11, Bradley P Knight6, Rishi K Arora6, Igor R Efimov2,4, John A Rogers1,2,5,8,13,22.
Abstract
Temporary postoperative cardiac pacing requires devices with percutaneous leads and external wired power and control systems. This hardware introduces risks for infection, limitations on patient mobility, and requirements for surgical extraction procedures. Bioresorbable pacemakers mitigate some of these disadvantages, but they demand pairing with external, wired systems and secondary mechanisms for control. We present a transient closed-loop system that combines a time-synchronized, wireless network of skin-integrated devices with an advanced bioresorbable pacemaker to control cardiac rhythms, track cardiopulmonary status, provide multihaptic feedback, and enable transient operation with minimal patient burden. The result provides a range of autonomous, rate-adaptive cardiac pacing capabilities, as demonstrated in rat, canine, and human heart studies. This work establishes an engineering framework for closed-loop temporary electrotherapy using wirelessly linked, body-integrated bioelectronic devices.Entities:
Mesh：
Year: 2022 PMID： 35617386 PMCID： PMC9282941 DOI： 10.1126/science.abm1703
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 63.714