Literature DB >> 33860087

Structure of Rad5 provides insights into its role in tolerance to replication stress.

Miaomiao Shen1, Nalini Dhingra2, Quan Wang3, Xiaoxin Gong1, Xin Xu1, Hengyao Niu3, Xiaolan Zhao2, Song Xiang1.   

Abstract

The Rad5 family of proteins are critical genome maintenance factors, with helicase-like transcription factor (HLTF) and SNF2 histone linker PHD RING helicase (SHRPH) in humans implicated in several types of cancer. How their multiple activities coordinate has been unclear. Our recent study on Rad5 shed light on this question.
© 2021 Taylor & Francis Group, LLC.

Entities:  

Keywords:  HIRAN domain; HLTF; Rad5; Replication stress; protein structure

Year:  2021        PMID： 33860087      PMCID： PMC8018420          DOI： 10.1080/23723556.2021.1889348

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

1.  RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO.

Authors:  Carsten Hoege; Boris Pfander; George-Lucian Moldovan; George Pyrowolakis; Stefan Jentsch
Journal:  Nature       Date:  2002-09-12       Impact factor: 49.962

2.  The HIRAN domain and recruitment of chromatin remodeling and repair activities to damaged DNA.

Authors:  Lakshminarayan M Iyer; M Madan Babu; L Aravind
Journal:  Cell Cycle       Date:  2006-04-01       Impact factor: 4.534

Review 3.  Replication fork reversal in eukaryotes: from dead end to dynamic response.

Authors:  Kai J Neelsen; Massimo Lopes
Journal:  Nat Rev Mol Cell Biol       Date:  2015-02-25       Impact factor: 94.444

4.  Rad5 Recruits Error-Prone DNA Polymerases for Mutagenic Repair of ssDNA Gaps on Undamaged Templates.

Authors:  David Gallo; TaeHyung Kim; Barnabas Szakal; Xanita Saayman; Ashrut Narula; Yoona Park; Dana Branzei; Zhaolei Zhang; Grant W Brown
Journal:  Mol Cell       Date:  2019-02-04       Impact factor: 17.970

5.  HLTF's Ancient HIRAN Domain Binds 3' DNA Ends to Drive Replication Fork Reversal.

Authors:  Andrew C Kile; Diana A Chavez; Julien Bacal; Sherif Eldirany; Dmitry M Korzhnev; Irina Bezsonova; Brandt F Eichman; Karlene A Cimprich
Journal:  Mol Cell       Date:  2015-06-04       Impact factor: 17.970

6.  Rad5 coordinates translesion DNA synthesis pathway by recognizing specific DNA structures in saccharomyces cerevisiae.

Authors:  Qifu Fan; Xin Xu; Xi Zhao; Qian Wang; Wei Xiao; Ying Guo; Yu V Fu
Journal:  Curr Genet       Date:  2018-02-02       Impact factor: 3.886

7.  DNA damage tolerance: when it's OK to make mistakes.

Authors:  Debbie J Chang; Karlene A Cimprich
Journal:  Nat Chem Biol       Date:  2009-01-15       Impact factor: 15.040

Review 8.  Rad5, HLTF, and SHPRH: A Fresh View of an Old Story.

Authors:  Menattallah Elserafy; Arwa A Abugable; Reham Atteya; Sherif F El-Khamisy
Journal:  Trends Genet       Date:  2018-05-26       Impact factor: 11.639

9.  Structural basis for the multi-activity factor Rad5 in replication stress tolerance.

Authors:  Miaomiao Shen; Nalini Dhingra; Quan Wang; Chen Cheng; Songbiao Zhu; Xiaolin Tian; Jun Yu; Xiaoxin Gong; Xuzhichao Li; Hongwei Zhang; Xin Xu; Liting Zhai; Min Xie; Ying Gao; Haiteng Deng; Yongning He; Hengyao Niu; Xiaolan Zhao; Song Xiang
Journal:  Nat Commun       Date:  2021-01-12       Impact factor: 14.919

10.  Yeast Rad5 protein required for postreplication repair has a DNA helicase activity specific for replication fork regression.

Authors:  András Blastyák; Lajos Pintér; Ildiko Unk; Louise Prakash; Satya Prakash; Lajos Haracska
Journal:  Mol Cell       Date:  2007-10-12       Impact factor: 17.970
  10 in total

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