Literature DB >> 30847757

New vasorelaxant indole alkaloids, taberniacins A and B, from Tabernaemontana divaricata.

Yusuke Hirasawa1, Xin Dai1, Jun Deguchi1, Shota Hatano1, Tadahiro Sasaki1, Ruri Ohtsuka1, Alfarius Eko Nugroho1, Toshio Kaneda1, Hiroshi Morita2.   

Abstract

Taberniacins A (1) and B (2), new indole alkaloids, were isolated from the stems of Tabernaemontana divaricata (Apocynaceae). Structure elucidation of 1 and 2 was based on spectroscopic methods and total synthesis. Each alkaloid showed vasorelaxant activity against phenylephrine-induced contraction of isolated rat aorta.

Entities:  

Keywords:  Indole alkaloid; Tabernaemontana divaricata; Taberniacin A; Taberniacin B; Vasorelaxant

Mesh：

Substances：

Year:  2019        PMID： 30847757     DOI： 10.1007/s11418-019-01293-9

Source DB:  PubMed          Journal:  J Nat Med        ISSN： 1340-3443            Impact factor:   2.343


  5 in total

1.  Two new sarpagine-type indole alkaloids and antimalarial activity of 16-demethoxycarbonylvoacamine from Tabernaemontana macrocarpa Jack.

Authors:  Puteri Amelia; Alfarius Eko Nugroho; Yusuke Hirasawa; Toshio Kaneda; Takahiro Tougan; Toshihiro Horii; Hiroshi Morita
Journal:  J Nat Med       Date:  2019-05-28       Impact factor: 2.343

2.  Leucophyllinines A and B, bisindole alkaloids from Leuconotis eugeniifolia.

Authors:  Yiming Tang; Alfarius Eko Nugroho; Yusuke Hirasawa; Takahiro Tougan; Toshihiro Horii; A Hamid A Hadi; Hiroshi Morita
Journal:  J Nat Med       Date:  2019-03-25       Impact factor: 2.343

3.  Chukranoids A-I, isopimarane diterpenoids from Chukrasia velutina.

Authors:  Alfarius Eko Nugroho; Masaki Tange; Sumi Kusakabe; Yusuke Hirasawa; Osamu Shirota; Michiyo Matsuno; Hajime Mizukami; Takahiro Tougan; Toshihiro Horii; Hiroshi Morita
Journal:  J Nat Med       Date:  2022-05-05       Impact factor: 3.192

Review 4.  Plant-Based Indole Alkaloids: A Comprehensive Overview from a Pharmacological Perspective.

Authors:  Faisal Omar; Abu Montakim Tareq; Ali M Alqahtani; Kuldeep Dhama; Mohammed Abu Sayeed; Talha Bin Emran; Jesus Simal-Gandara
Journal:  Molecules       Date:  2021-04-15       Impact factor: 4.411

5.  Two new bisindole alkaloids from Tabernaemontana macrocarpa Jack.

Authors:  Puteri Amelia; Alfarius Eko Nugroho; Yusuke Hirasawa; Toshio Kaneda; Takahiro Tougan; Toshihiro Horii; Hiroshi Morita
Journal:  J Nat Med       Date:  2021-04-06       Impact factor: 2.343
  5 in total

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