Carina Venter1, Michaela P Palumbo2, Katherine A Sauder3, Deborah H Glueck4, Anne P Starling5, Brandy M Ringham6, Liam O'Mahony7, Brianna F Moore6, Ivana V Yang8, Dana Dabelea9. 1. Children's Hospital Colorado, Aurora. Electronic address: Carina.Venter@childrenscolorado.org. 2. University of Colorado Anschutz Medical Campus, Aurora. 3. University of Colorado School of Medicine, Aurora; Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado Anschutz Medical Campus, Aurora. 4. Department of Pediatrics, University of Colorado School of Medicine, Aurora; Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, Aurora, CO. 5. Department of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora; LEAD Center, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora. 6. Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, Aurora, CO. 7. University College Cork, Cork, Ireland. 8. University of Colorado, Aurora. 9. Colorado School of Public Health, Anschutz Medical Campus, Aurora.
Abstract
BACKGROUND: Few studies have demonstrated associations between maternal dietary inflammatory index (DII) during pregnancy and offspring asthma and/or wheeze. OBJECTIVE: The study aimed to assess associations between maternal DII during pregnancy and 1) offspring cord sera pro-inflammatory cytokines (interleukin [IL]-1β, IL-4, IL-6, IL-10, tumor necrosis factor-α) and chemokines (IL-8, monocyte chemoattractant protein-1) at birth and 2) offspring asthma and/or wheeze at age 4 years. DESIGN: The Healthy Start study is a prospective prebirth longitudinal study that recruited pregnant women in Denver, Colorado and tracked their offspring. PARTICIPANTS AND SETTING: This study used data from 1228 mother-child dyads enrolled in the Healthy Start study. Pregnant women were recruited in Denver, Colorado, between 2009 and 2014, and offspring tracked until age 4 years. MAIN OUTCOME MEASURES: Cord sera cytokines and chemokines were analyzed with multiplex panel immunoassays. Offspring diagnosis of asthma and/or wheeze by age 4 years was extracted from electronic medical records. STATISTICAL ANALYSES PERFORMED: Unadjusted and adjusted linear and logistic regression models were used to assess associations. Covariates included factors such as nulliparity, race/ethnicity, gestational smoking, and maternal history of asthma. RESULTS: Unadjusted analysis showed that increasing maternal DII scores were associated with increased odds of child asthma and/or wheeze by 4 years (odds ratio = 1.17; 95% CI: 1.07-1.27), but the association was attenuated and no longer statistically significant in the adjusted model (odds ratio = 1.15; 95% CI: 0.99-1.33). There were no significant associations between DII scores and cord sera cytokine or chemokine levels. CONCLUSIONS: The study showed that the inflammatory profile of the maternal diet was not associated with cytokines and chemokine levels at birth. The results suggested that a more inflammatory maternal diet was associated with increased odds of offspring asthma and/or wheeze by age 4 years, which could be considered of clinical relevance but the finding was not statistically significant at the .05 level.
BACKGROUND: Few studies have demonstrated associations between maternal dietary inflammatory index (DII) during pregnancy and offspring asthma and/or wheeze. OBJECTIVE: The study aimed to assess associations between maternal DII during pregnancy and 1) offspring cord sera pro-inflammatory cytokines (interleukin [IL]-1β, IL-4, IL-6, IL-10, tumor necrosis factor-α) and chemokines (IL-8, monocyte chemoattractant protein-1) at birth and 2) offspring asthma and/or wheeze at age 4 years. DESIGN: The Healthy Start study is a prospective prebirth longitudinal study that recruited pregnant women in Denver, Colorado and tracked their offspring. PARTICIPANTS AND SETTING: This study used data from 1228 mother-child dyads enrolled in the Healthy Start study. Pregnant women were recruited in Denver, Colorado, between 2009 and 2014, and offspring tracked until age 4 years. MAIN OUTCOME MEASURES: Cord sera cytokines and chemokines were analyzed with multiplex panel immunoassays. Offspring diagnosis of asthma and/or wheeze by age 4 years was extracted from electronic medical records. STATISTICAL ANALYSES PERFORMED: Unadjusted and adjusted linear and logistic regression models were used to assess associations. Covariates included factors such as nulliparity, race/ethnicity, gestational smoking, and maternal history of asthma. RESULTS: Unadjusted analysis showed that increasing maternal DII scores were associated with increased odds of child asthma and/or wheeze by 4 years (odds ratio = 1.17; 95% CI: 1.07-1.27), but the association was attenuated and no longer statistically significant in the adjusted model (odds ratio = 1.15; 95% CI: 0.99-1.33). There were no significant associations between DII scores and cord sera cytokine or chemokine levels. CONCLUSIONS: The study showed that the inflammatory profile of the maternal diet was not associated with cytokines and chemokine levels at birth. The results suggested that a more inflammatory maternal diet was associated with increased odds of offspring asthma and/or wheeze by age 4 years, which could be considered of clinical relevance but the finding was not statistically significant at the .05 level.
Authors: V Bion; G A Lockett; N Soto-Ramírez; H Zhang; C Venter; W Karmaus; J W Holloway; S H Arshad Journal: Allergy Date: 2016-01-21 Impact factor: 13.146
Authors: Brianna F Moore; Katherine A Sauder; Anne P Starling; James R Hébert; Nitin Shivappa; Brandy M Ringham; Deborah H Glueck; Dana Dabelea Journal: J Pediatr Date: 2017-12-06 Impact factor: 4.406
Authors: Ling-Wei Chen; Becky Lyons; Pilar Navarro; Nitin Shivappa; John Mehegan; Celine M Murrin; James R Hébert; Cecily C Kelleher; Catherine M Phillips Journal: Am J Clin Nutr Date: 2020-02-01 Impact factor: 7.045
Authors: Olivia Schütte; Larissa Bachmann; Nitin Shivappa; James R Hebert; Janine F Felix; Stefan Röder; Ulrich Sack; Michael Borte; Wieland Kiess; Ana C Zenclussen; Gabriele I Stangl; Gunda Herberth; Kristin M Junge Journal: Front Nutr Date: 2022-04-08