Nitin Shivappa1,2, James R Hebert1,2, Ascensión Marcos3, Ligia-Esperanza Diaz3, Sonia Gomez3, Esther Nova3, Nathalie Michels4, Aline Arouca4, Esther González-Gil5, Gottrand Frederic6, Marcela González-Gross7,8, Manuel J Castillo9, Yannis Manios10, Mathilde Kersting11, Marc J Gunter12, Stefaan De Henauw4, Kafatos Antonios13, Kurt Widhalm14, Denes Molnar15, Luis Moreno5, Inge Huybrechts12. 1. Cancer Prevention and Control Program, University of South Carolina, Columbia, SC, USA. 2. Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA. 3. Department of Metabolism and Nutrition, Institute of Food Science and Technology and Nutrition, Madrid, Spain. 4. Department of Public Health, Ghent University, Ghent, Belgium. 5. GENUD "Growth, Exercise, NUtrition and Development" Research Group, Instituto Agroalimentario de Aragón (IA2), Instituto de Investigación Sanitaria Aragón (IIS Aragón), Faculty of Health Sciences Universidad de Zaragoza, Spain. 6. Univ. Lille, Inserm, CHU Lille, U995 - LIRIC - Lille Inflammation Research International Center, CIC 1403, Centre d'investigation Clinique, Lille, France. 7. ImFINE Research Group, Department of Health and Human Performance, Faculty of Physical Activity and Sport Sciences-INEF, Technical University of Madrid, Madrid, Spain. 8. Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBERObn), Instituto de Salud Carlos III, Madrid, España. 9. Department of Medical Physiology, School of Medicine, University of Granada, Granada, Spain. 10. Department of Nutrition and Dietetics, Harokopio University, Athens, Greece. 11. Research Institute of Child Nutrition Dortmund, University of Bonn, Germany. 12. International Agency for Research on Cancer, Nutrition and Metabolism Section, Lyon, France. 13. Preventive Medicine and Nutrition Unit, School of Medicine, University of Crete, Crete, Greece. 14. Department of Pediatrics, Division of Clinical Nutrition, Medical University of Vienna, Vienna, Austria. 15. Department of Pediatrics, University of Pecs, Pecs, Hungary.
Abstract
BACKGROUND: Previous research has shown that diet is associated with low-grade systemic inflammation among adults. However, no study has yet been conducted to explore the association between inflammatory potential of diet and low-grade systemic inflammation among adolescents whose dietary behavior may be different from adults. METHODS AND RESULTS: We examine the predictive ability of 24-h recall-derived dietary inflammatory index (DII) scores on inflammation among 532 European adolescents in the HELENA cross-sectional study. The DII is a literature-derived dietary index developed to predict inflammation. The DII was calculated per 1000 calories and was tested against C-reactive protein, ILs-1,2,4,10, TNF-α, ICAM, vascular cell adhesion molecule (VCAM), and IFN-γ. All inflammatory markers had nonnormal distributions and therefore were log transformed. Analyses were performed using multivariable linear regression, adjusting for age, sex, city, BMI, smoking, and physical activity. Pro-inflammatory diet (higher DII scores) was associated with increased levels of various inflammatory markers: TNF-α, IL-1, 2, IFN-γ, and vascular cell adhesion molecule (bDIIt3vs1 = 0.13, 95% CI: 0.001, 0.25; 0.13, 95% CI 0.001, 0.25; 0.40, 95% CI: 0.03, 0.77; 0.53, 95% CI: 0.05, 1.01; 0.07, 95% CI: 0.01, 0.13, respectively). CONCLUSION: These results reinforce the fact that diet, as a whole, plays an important role in modifying inflammation in adolescents.
BACKGROUND: Previous research has shown that diet is associated with low-grade systemic inflammation among adults. However, no study has yet been conducted to explore the association between inflammatory potential of diet and low-grade systemic inflammation among adolescents whose dietary behavior may be different from adults. METHODS AND RESULTS: We examine the predictive ability of 24-h recall-derived dietary inflammatory index (DII) scores on inflammation among 532 European adolescents in the HELENA cross-sectional study. The DII is a literature-derived dietary index developed to predict inflammation. The DII was calculated per 1000 calories and was tested against C-reactive protein, ILs-1,2,4,10, TNF-α, ICAM, vascular cell adhesion molecule (VCAM), and IFN-γ. All inflammatory markers had nonnormal distributions and therefore were log transformed. Analyses were performed using multivariable linear regression, adjusting for age, sex, city, BMI, smoking, and physical activity. Pro-inflammatory diet (higher DII scores) was associated with increased levels of various inflammatory markers: TNF-α, IL-1, 2, IFN-γ, and vascular cell adhesion molecule (bDIIt3vs1 = 0.13, 95% CI: 0.001, 0.25; 0.13, 95% CI 0.001, 0.25; 0.40, 95% CI: 0.03, 0.77; 0.53, 95% CI: 0.05, 1.01; 0.07, 95% CI: 0.01, 0.13, respectively). CONCLUSION: These results reinforce the fact that diet, as a whole, plays an important role in modifying inflammation in adolescents.
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Authors: Nitin Shivappa; James R Hébert; Ernst R Rietzschel; Marc L De Buyzere; Michel Langlois; Evi Debruyne; Ascensión Marcos; Inge Huybrechts Journal: Br J Nutr Date: 2015-02-02 Impact factor: 3.718
Authors: L A Moreno; M Kersting; S de Henauw; M González-Gross; W Sichert-Hellert; C Matthys; M I Mesana; N Ross Journal: Int J Obes (Lond) Date: 2005-09 Impact factor: 5.095
Authors: Inga Villa; Agneta Yngve; Eric Poortvliet; Andrej Grjibovski; Krystiine Liiv; Michael Sjöström; Maarike Harro Journal: Public Health Nutr Date: 2007-03 Impact factor: 4.022
Authors: Nitin Shivappa; Susan E Steck; Thomas G Hurley; James R Hussey; Yunsheng Ma; Ira S Ockene; Fred Tabung; James R Hébert Journal: Public Health Nutr Date: 2013-10-10 Impact factor: 4.022
Authors: Daria M McMahon; James B Burch; James R Hébert; James W Hardin; Jiajia Zhang; Michael D Wirth; Shawn D Youngstedt; Nitin Shivappa; Steven J Jacobsen; Bette Caan; Stephen K Van Den Eeden Journal: Ann Epidemiol Date: 2018-11-02 Impact factor: 3.797
Authors: Joseph Firth; Brendon Stubbs; Scott B Teasdale; Philip B Ward; Nicola Veronese; Nitin Shivappa; James R Hebert; Michael Berk; Alison R Yung; Jerome Sarris Journal: World Psychiatry Date: 2018-10 Impact factor: 49.548
Authors: Kathleen M Hayden; Daniel P Beavers; Susan E Steck; James R Hebert; Fred K Tabung; Nitin Shivappa; Ramon Casanova; JoAnn E Manson; Claudia B Padula; Elena Salmoirago-Blotcher; Linda G Snetselaar; Oleg Zaslavsky; Stephen R Rapp Journal: Alzheimers Dement Date: 2017-05-19 Impact factor: 21.566
Authors: A M Hodge; J K Bassett; P-A Dugué; N Shivappa; J R Hébert; R L Milne; D R English; G G Giles Journal: Nutr Metab Cardiovasc Dis Date: 2018-02-07 Impact factor: 4.222
Authors: Stefanos Tyrovolas; Ai Koyanagi; Georgios A Kotsakis; Demosthenes Panagiotakos; Nitin Shivappa; Michael D Wirth; James R Hébert; Josep Maria Haro Journal: Int J Cardiol Date: 2017-05-01 Impact factor: 4.164
Authors: Avelina C Padin; James R Hébert; Alex Woody; Stephanie J Wilson; Nitin Shivappa; Martha A Belury; William B Malarkey; John F Sheridan; Janice K Kiecolt-Glaser Journal: Brain Behav Immun Date: 2019-07-26 Impact factor: 7.217
Authors: Nitin Shivappa; Marialaura Bonaccio; James R Hebert; Augusto Di Castelnuovo; Simona Costanzo; Emilia Ruggiero; George Pounis; Maria Benedetta Donati; Giovanni de Gaetano; Licia Iacoviello Journal: Nutrition Date: 2018-04-21 Impact factor: 4.008