BACKGROUND: Asthma is the most common childhood chronic health condition. Maternal antenatal diet has been associated with offspring asthma risk, but studies investigating maternal whole diet quality and inflammatory potential with long-term offspring follow-up (>5 y) are rare. OBJECTIVES: We aimed to elucidate these associations in a prospective cohort study in Ireland. METHODS: Early pregnancy diets were assessed using a validated FFQ from which energy-adjusted Dietary Inflammatory Index (E-DII) and Healthy Eating Index (HEI)-2015 scores were computed. Doctor-diagnosed offspring asthma status (general practitioner or parent reports) for the first 10 y of life was collected at 3-y, 5-y, and 9-y follow-up. A total of 862 mother-child pairs with information on maternal diet and ≥1 offspring asthma data points were included. The longitudinal associations between maternal E-DII and HEI scores and offspring asthma status were assessed using generalized estimating equations. RESULTS: Cumulative offspring asthma incidence was 21% over the 10-y period. In the main models, adjusted for maternal lifestyle and sociodemographic factors, a higher E-DII score, indicating a more proinflammatory diet, was associated with higher risk of offspring asthma (OR: 1.35; 95% CI: 1.10, 1.65; per 1-SD score increment), whereas a higher HEI-2015 score, indicating better dietary quality, was associated with lower risk (OR: 0.77; 95% CI: 0.64, 0.93) (both P < 0.01). Results persisted with further adjustment for childhood factors (e.g., breastfeeding, diet, and childcare attendance) and parental asthma history. Similar associations were observed when E-DII and HEI-2015 scores were modeled in quartiles (both P-trend < 0.05). Associations for HEI-2015 were attenuated after adjustment for E-DII, suggesting the importance of anti-inflammatory pathways. CONCLUSIONS: Our results suggest that a proinflammatory and low-quality diet during pregnancy is associated with a higher risk of offspring asthma. Pending confirmation from other studies, optimizing these aspects of maternal diet can be a promising strategy for reducing childhood asthma risk. This prospective observational study was registered at the ISRCTN Registry as ISRCTN16537904.
BACKGROUND:Asthma is the most common childhood chronic health condition. Maternal antenatal diet has been associated with offspring asthma risk, but studies investigating maternal whole diet quality and inflammatory potential with long-term offspring follow-up (>5 y) are rare. OBJECTIVES: We aimed to elucidate these associations in a prospective cohort study in Ireland. METHODS: Early pregnancy diets were assessed using a validated FFQ from which energy-adjusted Dietary Inflammatory Index (E-DII) and Healthy Eating Index (HEI)-2015 scores were computed. Doctor-diagnosed offspring asthma status (general practitioner or parent reports) for the first 10 y of life was collected at 3-y, 5-y, and 9-y follow-up. A total of 862 mother-child pairs with information on maternal diet and ≥1 offspring asthma data points were included. The longitudinal associations between maternal E-DII and HEI scores and offspring asthma status were assessed using generalized estimating equations. RESULTS: Cumulative offspring asthma incidence was 21% over the 10-y period. In the main models, adjusted for maternal lifestyle and sociodemographic factors, a higher E-DII score, indicating a more proinflammatory diet, was associated with higher risk of offspring asthma (OR: 1.35; 95% CI: 1.10, 1.65; per 1-SD score increment), whereas a higher HEI-2015 score, indicating better dietary quality, was associated with lower risk (OR: 0.77; 95% CI: 0.64, 0.93) (both P < 0.01). Results persisted with further adjustment for childhood factors (e.g., breastfeeding, diet, and childcare attendance) and parental asthma history. Similar associations were observed when E-DII and HEI-2015 scores were modeled in quartiles (both P-trend < 0.05). Associations for HEI-2015 were attenuated after adjustment for E-DII, suggesting the importance of anti-inflammatory pathways. CONCLUSIONS: Our results suggest that a proinflammatory and low-quality diet during pregnancy is associated with a higher risk of offspring asthma. Pending confirmation from other studies, optimizing these aspects of maternal diet can be a promising strategy for reducing childhood asthma risk. This prospective observational study was registered at the ISRCTN Registry as ISRCTN16537904.
Authors: Carina Venter; Michaela P Palumbo; Deborah H Glueck; Katherine A Sauder; Liam O'Mahony; David M Fleischer; Miriam Ben-Abdallah; Brandy M Ringham; Dana Dabelea Journal: Allergy Date: 2021-06-09 Impact factor: 14.710
Authors: Carina Venter; Michaela P Palumbo; Katherine A Sauder; Deborah H Glueck; Anne P Starling; Brandy M Ringham; Liam O'Mahony; Brianna F Moore; Ivana V Yang; Dana Dabelea Journal: J Acad Nutr Diet Date: 2021-03-17 Impact factor: 5.234
Authors: Carina Venter; Carlo Agostoni; S Hasan Arshad; Miriam Ben-Abdallah; George Du Toit; David M Fleischer; Matthew Greenhawt; Deborah H Glueck; Marion Groetch; Nonhlanhla Lunjani; Kate Maslin; Alexander Maiorella; Rosan Meyer; Muraro Antonella; Merryn J Netting; Bright Ibeabughichi Nwaru; Debra J Palmer; Micheala P Palumbo; Graham Roberts; Caroline Roduit; Pete Smith; Eva Untersmayr; Lauren A Vanderlinden; Liam O'Mahony Journal: Pediatr Allergy Immunol Date: 2020-08-06 Impact factor: 5.464
Authors: Sara M Mensink-Bout; Evelien R van Meel; Johan C de Jongste; Isabella Annesi-Maesano; Adrien M Aubert; Jonathan Y Bernard; Ling-Wei Chen; Cyrus Cooper; Sarah R Crozier; Wojciech Hanke; Nicholas C Harvey; James R Hébert; Barbara Heude; Joanna Jerzynska; Cecily C Kelleher; John Mehegan; Fionnuala M McAuliffe; Catherine M Phillips; Kinga Polanska; Caroline L Relton; Nitin Shivappa; Matthew Suderman; Vincent W V Jaddoe; Liesbeth Duijts Journal: Eur Respir J Date: 2022-04-21 Impact factor: 33.795
Authors: Annabelle Bédard; Zhen Li; Wassila Ait-Hadad; Carlos A Camargo; Bénédicte Leynaert; Christophe Pison; Orianne Dumas; Raphaëlle Varraso Journal: Int J Environ Res Public Health Date: 2021-03-15 Impact factor: 3.390