| Literature DB >> 33665639 |
John R Speakman1,2,3,4, Yosuke Yamada5,6, Hiroyuki Sagayama7, Elena S F Berman8, Philip N Ainslie9, Lene F Andersen10, Liam J Anderson9,11, Lenore Arab12, Issaad Baddou13, Kweku Bedu-Addo14, Ellen E Blaak15, Stephane Blanc16,17, Alberto G Bonomi18, Carlijn V C Bouten19, Pascal Bovet20, Maciej S Buchowski21, Nancy F Butte22, Stefan G J A Camps15, Graeme L Close9, Jamie A Cooper16, Seth A Creasy23, Sai Krupa Das24, Richard Cooper25, Lara R Dugas25, Cara B Ebbeling26, Ulf Ekelund27, Sonja Entringer28,29, Terrence Forrester30, Barry W Fudge31, Annelies H Goris15, Michael Gurven32, Catherine Hambly2, Asmaa El Hamdouchi13, Marije B Hoos15, Sumei Hu3, Noorjehan Joonas33, Annemiek M Joosen15, Peter Katzmarzyk34, Kitty P Kempen15, Misaka Kimura6, William E Kraus35, Robert F Kushner36, Estelle V Lambert37, William R Leonard38, Nader Lessan39, David S Ludwig26, Corby K Martin34, Anine C Medin10,40, Erwin P Meijer15, James C Morehen9,41, James P Morton9, Marian L Neuhouser42, Theresa A Nicklas22, Robert M Ojiambo43,44, Kirsi H Pietiläinen45, Yannis P Pitsiladis46, Jacob Plange-Rhule14, Guy Plasqui47, Ross L Prentice42, Roberto A Rabinovich48, Susan B Racette24, David A Raichlen49, Eric Ravussin34, Rebecca M Reynolds50, Susan B Roberts24, Albertine J Schuit51, Anders M Sjödin52, Eric Stice53, Samuel S Urlacher54, Giulio Valenti15, Ludo M Van Etten15, Edgar A Van Mil55, Jonathan C K Wells56, George Wilson9, Brian M Wood57,58, Jack Yanovski59, Tsukasa Yoshida5, Xueying Zhang1,2, Alexia J Murphy-Alford60, Cornelia U Loechl60, Edward L Melanson23,61,62, Amy H Luke63, Herman Pontzer64,65, Jennifer Rood34, Dale A Schoeller66, Klaas R Westerterp67, William W Wong22.
Abstract
The doubly labeled water (DLW) method measures total energy expenditure (TEE) in free-living subjects. Several equations are used to convert isotopic data into TEE. Using the International Atomic Energy Agency (IAEA) DLW database (5,756 measurements of adults and children), we show considerable variability is introduced by different equations. The estimated rCO2 is sensitive to the dilution space ratio (DSR) of the two isotopes. Based on performance in validation studies, we propose a new equation based on a new estimate of the mean DSR. The DSR is lower at low body masses (<10 kg). Using data for 1,021 babies and infants, we show that the DSR varies non-linearly with body mass between 0 and 10 kg. Using this relationship to predict DSR from weight provides an equation for rCO2 over this size range that agrees well with indirect calorimetry (average difference 0.64%; SD = 12.2%). We propose adoption of these equations in future studies.Entities:
Keywords: doubly labeled water; free-living; total energy expenditure; validation
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Year: 2021 PMID： 33665639 PMCID： PMC7897799 DOI： 10.1016/j.xcrm.2021.100203
Source DB: PubMed Journal: Cell Rep Med ISSN： 2666-3791