| Literature DB >> 34385400 |
Herman Pontzer1,2, Yosuke Yamada3,4, Hiroyuki Sagayama5, Amy H Luke6, Jennifer Rood7, Dale A Schoeller8, Klaas R Westerterp9, William W Wong10, John R Speakman11,12,13,14, Philip N Ainslie15, Lene F Andersen16, Liam J Anderson15,17, Lenore Arab18, Issaad Baddou19, Kweku Bedu-Addo20, Ellen E Blaak21, Stephane Blanc22,23, Alberto G Bonomi24, Carlijn V C Bouten21, Pascal Bovet25, Maciej S Buchowski26, Nancy F Butte27, Stefan G Camps21, Graeme L Close15, Jamie A Cooper22, Richard Cooper28, Sai Krupa Das29, Lara R Dugas28, Ulf Ekelund30, Sonja Entringer31,32, Terrence Forrester33, Barry W Fudge34, Annelies H Goris21, Michael Gurven35, Catherine Hambly12, Asmaa El Hamdouchi19, Marjije B Hoos21, Sumei Hu13, Noorjehan Joonas36, Annemiek M Joosen21, Peter Katzmarzyk37, Kitty P Kempen21, Misaka Kimura38, William E Kraus39, Robert F Kushner40, Estelle V Lambert41, William R Leonard42, Nader Lessan43, Corby Martin37, Anine C Medin16,44, Erwin P Meijer21, James C Morehen45,15, James P Morton15, Marian L Neuhouser46, Teresa A Nicklas27, Robert M Ojiambo47,48, Kirsi H Pietiläinen49, Yannis P Pitsiladis50, Jacob Plange-Rhule20, Guy Plasqui51, Ross L Prentice46, Roberto A Rabinovich52, Susan B Racette53, David A Raichlen54, Eric Ravussin37, Rebecca M Reynolds55, Susan B Roberts29, Albertine J Schuit56, Anders M Sjödin57, Eric Stice58, Samuel S Urlacher59, Giulio Valenti21,24, Ludo M Van Etten21, Edgar A Van Mil60, Jonathan C K Wells61, George Wilson15, Brian M Wood62,63, Jack Yanovski64, Tsukasa Yoshida4, Xueying Zhang12,13, Alexia J Murphy-Alford65, Cornelia Loechl65.
Abstract
Total daily energy expenditure ("total expenditure") reflects daily energy needs and is a critical variable in human health and physiology, but its trajectory over the life course is poorly studied. We analyzed a large, diverse database of total expenditure measured by the doubly labeled water method for males and females aged 8 days to 95 years. Total expenditure increased with fat-free mass in a power-law manner, with four distinct life stages. Fat-free mass-adjusted expenditure accelerates rapidly in neonates to ~50% above adult values at ~1 year; declines slowly to adult levels by ~20 years; remains stable in adulthood (20 to 60 years), even during pregnancy; then declines in older adults. These changes shed light on human development and aging and should help shape nutrition and health strategies across the life span.Entities:
Mesh：
Year: 2021 PMID： 34385400 PMCID： PMC8370708 DOI： 10.1126/science.abe5017
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 63.714