Guobing Liu1,2,3,4, Pengcheng Hu1,2,3,4, Haojun Yu1,2,3,4, Hui Tan1,2,3,4, Yiqiu Zhang1,2,3,4, Hongyan Yin1,2,3,4, Yan Hu1,2,3,4, Jianying Gu5,6, Hongcheng Shi7,8,9,10. 1. Department of Nuclear Medicine, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Shanghai, 200032, People's Republic of China. 2. Institute of Nuclear Medicine, Fudan University, Shanghai, China. 3. Shanghai Institute of Medical Imaging, Shanghai, China. 4. Cancer Prevention and Treatment Center, Zhongshan Hospital, Fudan University, Shanghai, China. 5. Cancer Prevention and Treatment Center, Zhongshan Hospital, Fudan University, Shanghai, China. gu.jianying@zs-hospital.sh.cn. 6. Department of Plastic surgery, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Shanghai, 200032, People's Republic of China. gu.jianying@zs-hospital.sh.cn. 7. Department of Nuclear Medicine, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Shanghai, 200032, People's Republic of China. shi.hongcheng@zs-hospital.sh.cn. 8. Institute of Nuclear Medicine, Fudan University, Shanghai, China. shi.hongcheng@zs-hospital.sh.cn. 9. Shanghai Institute of Medical Imaging, Shanghai, China. shi.hongcheng@zs-hospital.sh.cn. 10. Cancer Prevention and Treatment Center, Zhongshan Hospital, Fudan University, Shanghai, China. shi.hongcheng@zs-hospital.sh.cn.
Abstract
PURPOSE: To investigate the feasibility of ultra-low-activity total-body positron emission tomography (PET) dynamic imaging for quantifying kinetic metrics of 2-[18F]-fluoro-2-deoxy-D-glucose (18F-FDG) in normal organs and to verify its clinical relevance with full-activity imaging. METHODS: Dynamic total-body PET imaging was performed in 20 healthy volunteers, with eight using full activity (3.7 MBq/kg) of 18F-FDG and 12 using 10× activity reduction (0.37 MBq/kg). Image contrast, in terms of liver-to-muscle ratio (LMR), liver-to-blood ratio (LBR), and blood-to-muscle ratio (BMR) of radioactivity concentrations were assessed. A two-tissue compartment model was fitted to the time-to-activity curves in organs based on regions of interest (ROIs) delineation using PMOD, and constant rates (k1, k2, and k3) were generated. Kinetic constants, corresponding coefficients of variance (CoVs), image contrast, radiation dose, prompt counts, and data size were compared between full- and low-activity groups. RESULTS: All constant rates, corresponding CoVs, and image contrast in different organs were comparable with none significant differences between full- and ultra-low-activity groups. PET images in the ultra-low-activity group generated significantly lower effective radiation dose (median, 0.419 vs. 4.886 mSv, P < 0.001), reduced prompt counts (median, 2.79 vs. 55.68 billion, P < 0.001), and smaller data size (median, 71.11 vs. 723.18 GB, P < 0.001). CONCLUSION: Total-body dynamic PET imaging using 10× reduction of injected activity could achieve relevant kinetic metrics of 18F-FDG and comparable image contrast with full-activity imaging. Activity reduction results in significant decrease of radiation dose and data size, rendering it more acceptable and easier for data reconstruction, transmission, and storage for clinical practice.
PURPOSE: To investigate the feasibility of ultra-low-activity total-body positron emission tomography (PET) dynamic imaging for quantifying kinetic metrics of 2-[18F]-fluoro-2-deoxy-D-glucose (18F-FDG) in normal organs and to verify its clinical relevance with full-activity imaging. METHODS: Dynamic total-body PET imaging was performed in 20 healthy volunteers, with eight using full activity (3.7 MBq/kg) of 18F-FDG and 12 using 10× activity reduction (0.37 MBq/kg). Image contrast, in terms of liver-to-muscle ratio (LMR), liver-to-blood ratio (LBR), and blood-to-muscle ratio (BMR) of radioactivity concentrations were assessed. A two-tissue compartment model was fitted to the time-to-activity curves in organs based on regions of interest (ROIs) delineation using PMOD, and constant rates (k1, k2, and k3) were generated. Kinetic constants, corresponding coefficients of variance (CoVs), image contrast, radiation dose, prompt counts, and data size were compared between full- and low-activity groups. RESULTS: All constant rates, corresponding CoVs, and image contrast in different organs were comparable with none significant differences between full- and ultra-low-activity groups. PET images in the ultra-low-activity group generated significantly lower effective radiation dose (median, 0.419 vs. 4.886 mSv, P < 0.001), reduced prompt counts (median, 2.79 vs. 55.68 billion, P < 0.001), and smaller data size (median, 71.11 vs. 723.18 GB, P < 0.001). CONCLUSION: Total-body dynamic PET imaging using 10× reduction of injected activity could achieve relevant kinetic metrics of 18F-FDG and comparable image contrast with full-activity imaging. Activity reduction results in significant decrease of radiation dose and data size, rendering it more acceptable and easier for data reconstruction, transmission, and storage for clinical practice.
Authors: Hasan Sari; Mohammadreza Teimoorisichani; Clemens Mingels; Ian Alberts; Vladimir Panin; Deepak Bharkhada; Song Xue; George Prenosil; Kuangyu Shi; Maurizio Conti; Axel Rominger Journal: Eur J Nucl Med Mol Imaging Date: 2022-07-19 Impact factor: 10.057
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Authors: Edwin K Leung; Yasser G Abdelhafez; Eric Berg; Zhaoheng Xie; Xuezhu Zhang; Reimund Bayerlein; Benjamin Spencer; Elizabeth Li; Negar Omidvari; Aaron Selfridge; Simon R Cherry; Jinyi Qi; Ramsey D Badawi Journal: Phys Med Biol Date: 2022-06-10 Impact factor: 4.174
Authors: Hasan Sari; Clemens Mingels; Ian Alberts; Jicun Hu; Dorothee Buesser; Vijay Shah; Robin Schepers; Patrik Caluori; Vladimir Panin; Maurizio Conti; Ali Afshar-Oromieh; Kuangyu Shi; Lars Eriksson; Axel Rominger; Paul Cumming Journal: Eur J Nucl Med Mol Imaging Date: 2022-01-04 Impact factor: 10.057