Wanqi Chen1,2, Lei Liu1,2, Yinghe Li1,2, Shatong Li1,2, Zhijian Li1,2, Weiguang Zhang1,2, Xu Zhang1,2, Runze Wu3, Debin Hu3, Hongyan Sun3, Yun Zhou3, Wei Fan1,2, Yumo Zhao4,5, Yizhuo Zhang6,7, Yingying Hu8,9. 1. State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, 651 Dongfengdong Road, Guangzhou, 510060, Guangdong, China. 2. Department of Nuclear Medicine, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China. 3. Central Research Institute, United Imaging Healthcare Group Co., Ltd, Shanghai, China. 4. State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, 651 Dongfengdong Road, Guangzhou, 510060, Guangdong, China. zhaoym@sysucc.org.cn. 5. Department of Nuclear Medicine, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China. zhaoym@sysucc.org.cn. 6. State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, 651 Dongfengdong Road, Guangzhou, 510060, Guangdong, China. zhangyzh@sysucc.org.cn. 7. Department of Pediatric Oncology, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China. zhangyzh@sysucc.org.cn. 8. State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, 651 Dongfengdong Road, Guangzhou, 510060, Guangdong, China. huyy@sysucc.org.cn. 9. Department of Nuclear Medicine, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China. huyy@sysucc.org.cn.
Abstract
PURPOSE: To explore the impact of a true half dose of [18F]-FDG on image quality in pediatric oncological patients undergoing total-body PET/CT and investigate short acquisition times with half-dose injected activity. METHODS: One hundred pediatric oncological patients who underwent total-body PET/CT using the uEXPLORER scanner after receiving a true half dose of [18F]-FDG (1.85 MBq/kg) were retrospectively enrolled. The PET images were first reconstructed using complete 600-s data and then split into 300-s, 180-s, 60-s, 40-s, and 20-s duration groups (G600 to G20). The subjective analysis was performed using 5-point Likert scales. Objective quantitative metrics included the maximum standard uptake value (SUVmax), SUVmean, standard deviation (SD), signal-to-noise ratio (SNR), and SNRnorm of the background. The variabilities in lesion SUVmean, SUVmax, and tumor-to-background ratio (TBR) were also calculated. RESULTS: The overall image quality scores in the G600, G300, G180, and G60 groups were 4.9 ± 0.2, 4.9 ± 0.3, 4.4 ± 0.5, and 3.5 ± 0.5 points, respectively. All the lesions identified in the half-dose images were localized in the G60 images, while 56% of the lesions could be clearly identified in the G20 images. With reduced acquisition time, the SUVmax and SD of the backgrounds were gradually increased, while the TBR values showed no statistically significant differences among the groups (all p > 0.1). Using the half-dose images as a reference, the variability in the lesion SUVmax gradually increased from the G180 to G20 images, while the lesion SUVmean remained stable across all age groups. SNRnorm was highly negatively correlated with age. CONCLUSION: Total-body PET/CT with a half dose of [18F]-FDG (1.85 MBq/kg, estimated whole-body effective dose: 1.76-2.57 mSv) achieved good performance in pediatric patients, with sufficient image quality and good lesion conspicuity. Sufficient image quality and lesion conspicuity could be maintained at a fast scanning time of 60 s with half-dose activity.
PURPOSE: To explore the impact of a true half dose of [18F]-FDG on image quality in pediatric oncological patients undergoing total-body PET/CT and investigate short acquisition times with half-dose injected activity. METHODS: One hundred pediatric oncological patients who underwent total-body PET/CT using the uEXPLORER scanner after receiving a true half dose of [18F]-FDG (1.85 MBq/kg) were retrospectively enrolled. The PET images were first reconstructed using complete 600-s data and then split into 300-s, 180-s, 60-s, 40-s, and 20-s duration groups (G600 to G20). The subjective analysis was performed using 5-point Likert scales. Objective quantitative metrics included the maximum standard uptake value (SUVmax), SUVmean, standard deviation (SD), signal-to-noise ratio (SNR), and SNRnorm of the background. The variabilities in lesion SUVmean, SUVmax, and tumor-to-background ratio (TBR) were also calculated. RESULTS: The overall image quality scores in the G600, G300, G180, and G60 groups were 4.9 ± 0.2, 4.9 ± 0.3, 4.4 ± 0.5, and 3.5 ± 0.5 points, respectively. All the lesions identified in the half-dose images were localized in the G60 images, while 56% of the lesions could be clearly identified in the G20 images. With reduced acquisition time, the SUVmax and SD of the backgrounds were gradually increased, while the TBR values showed no statistically significant differences among the groups (all p > 0.1). Using the half-dose images as a reference, the variability in the lesion SUVmax gradually increased from the G180 to G20 images, while the lesion SUVmean remained stable across all age groups. SNRnorm was highly negatively correlated with age. CONCLUSION: Total-body PET/CT with a half dose of [18F]-FDG (1.85 MBq/kg, estimated whole-body effective dose: 1.76-2.57 mSv) achieved good performance in pediatric patients, with sufficient image quality and good lesion conspicuity. Sufficient image quality and lesion conspicuity could be maintained at a fast scanning time of 60 s with half-dose activity.
Authors: Frederic H Fahey; Alison Goodkind; Robert D MacDougall; Leah Oberg; Sonja I Ziniel; Richard Cappock; Michael J Callahan; Neha Kwatra; S Ted Treves; Stephan D Voss Journal: J Nucl Med Date: 2017-07-07 Impact factor: 10.057
Authors: R A J Nievelstein; H M E Quarles van Ufford; T C Kwee; M B Bierings; I Ludwig; F J A Beek; J M H de Klerk; W P Th M Mali; P W de Bruin; J Geleijns Journal: Eur Radiol Date: 2012-04-27 Impact factor: 5.315
Authors: G L Poli; L Torres; M Coca; M Veselinovic; M Lassmann; H Delis; F Fahey Journal: Eur J Nucl Med Mol Imaging Date: 2019-12-08 Impact factor: 9.236
Authors: Soni C Chawla; Noah Federman; Di Zhang; Kristen Nagata; Soujanya Nuthakki; Michael McNitt-Gray; M Ines Boechat Journal: Pediatr Radiol Date: 2009-12-05