Literature DB >> 33326951

Energy and electron drift time measurements in a pixel CCI TlBr detector with 1.3 MeV prompt-gammas.

Gerard Ariño-Estrada1, Hadong Kim2, Junwei Du1, Leonard J Cirignano2, Kanai S Shah2, Simon R Cherry1.   

Abstract

Assessing the position of the Bragg peak (BP) in hadron radiotherapy utilizing prompt-gamma imaging (PGI) presents many challenges in terms of detector physics. Gamma detectors with the capability of extracting the best energy, timing, and spatial information from each gamma interaction, as well as with high detection efficiency and count rate performance, are needed for this application. In this work we present the characterization of a pixel Čerenkov charge induction (CCI) thallium bromide (TlBr) detector in terms of energy and and electron drift time for its potential use in PGI. The CCI TlBr detector had dimensions of 4 × 4 × 5 mm3 and one of its electrodes was segmented in pixels with 1.7 mm pitch. A silicon photomultiplier (SiPM) was optically coupled to one of the faces of the TlBr slab to read out the Čerenkov light promptly emitted after the interaction of a gamma ray. The detector was operated stand-alone and the 1.275 prompt gammas from a 22Na radioactive source were used for the study. The electron drift time was obtained by combining the Čerenkov and charge induction signals and then used as a measure of the depth of interaction. The electron mobility in TlBr was estimated as ∼27 cm2 V-1 s-1. Energy resolutions between 3.4% and 4.0% at 1.275 MeV were obtained after depth-correction. These values improved to 3.0%-3.3% when events with drift times of 3-6 μs were selected. These results show the potential of pixel CCI TlBr detectors to resolve gamma interactions in the detector with mm-like accuracy in 3D and with excellent energy resolution. Previous studies with CCI TlBr devices have shown a timing resolution of <400 ps full width at half maximum when detecting 511 keV gamma rays, therefore, the timing accuracy is expected to improve with the increased energy of the gamma rays in PGI. While other important detector characteristics such as count rate capability remain to be studied, results from this work combined with other preliminary data show pixel CCI detectors can simultaneously provide excellent energy, timing, and spatial resolution performance and are a very promising option for PGI in hadron therapy.

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Year:  2021        PMID: 33326951      PMCID: PMC9020464          DOI: 10.1088/1361-6560/abd419

Source DB:  PubMed          Journal:  Phys Med Biol        ISSN: 0031-9155            Impact factor:   4.174


  10 in total

1.  Charge transport in arrays of semiconductor gamma-ray detectors.

Authors: 
Journal:  Phys Rev Lett       Date:  1995-07-03       Impact factor: 9.161

2.  Range assessment in particle therapy based on prompt γ-ray timing measurements.

Authors:  Christian Golnik; Fernando Hueso-González; Andreas Müller; Peter Dendooven; Wolfgang Enghardt; Fine Fiedler; Thomas Kormoll; Katja Roemer; Johannes Petzoldt; Andreas Wagner; Guntram Pausch
Journal:  Phys Med Biol       Date:  2014-08-26       Impact factor: 3.609

3.  Towards time-of-flight PET with a semiconductor detector.

Authors:  Gerard Ariño-Estrada; Gregory S Mitchell; Sun Il Kwon; Junwei Du; Hadong Kim; Leonard J Cirignano; Kanai S Shah; Simon R Cherry
Journal:  Phys Med Biol       Date:  2018-02-16       Impact factor: 3.609

4.  First Cerenkov charge-induction (CCI) TlBr detector for TOF-PET and proton range verification.

Authors:  Gerard Ariño-Estrada; Gregory S Mitchell; Hadong Kim; Junwei Du; Sun Il Kwon; Leonard J Cirignano; Kanai S Shah; Simon R Cherry
Journal:  Phys Med Biol       Date:  2019-08-28       Impact factor: 3.609

Review 5.  Charged-particle therapy in cancer: clinical uses and future perspectives.

Authors:  Marco Durante; Roberto Orecchia; Jay S Loeffler
Journal:  Nat Rev Clin Oncol       Date:  2017-03-14       Impact factor: 66.675

6.  Study of Čerenkov Light Emission in the Semiconductors TlBr and TlCl for TOF-PET.

Authors:  Gerard Ariño-Estrada; Emilie Roncali; Aaron R Selfridge; Junwei Du; Jaroslaw Glodo; Kanai S Shah; Simon R Cherry
Journal:  IEEE Trans Radiat Plasma Med Sci       Date:  2020-09-17

7.  A full-scale clinical prototype for proton range verification using prompt gamma-ray spectroscopy.

Authors:  Fernando Hueso-González; Moritz Rabe; Thomas A Ruggieri; Thomas Bortfeld; Joost M Verburg
Journal:  Phys Med Biol       Date:  2018-09-17       Impact factor: 3.609

8.  Development of TlBr detectors for PET imaging.

Authors:  Gerard Ariño-Estrada; Junwei Du; Hadong Kim; Leonard J Cirignano; Kanai S Shah; Simon R Cherry; Gregory S Mitchell
Journal:  Phys Med Biol       Date:  2018-07-03       Impact factor: 3.609

9.  Hybrid pixel-waveform CdTe/CZT detector for use in an ultrahigh resolution MRI compatible SPECT system.

Authors:  Liang Cai; Ling-Jian Meng
Journal:  Nucl Instrum Methods Phys Res A       Date:  2013-02-01       Impact factor: 1.455

10.  First Images of a Three-Layer Compton Telescope Prototype for Treatment Monitoring in Hadron Therapy.

Authors:  Gabriela Llosá; Marco Trovato; John Barrio; Ane Etxebeste; Enrique Muñoz; Carlos Lacasta; Josep F Oliver; Magdalena Rafecas; Carles Solaz; Paola Solevi
Journal:  Front Oncol       Date:  2016-02-02       Impact factor: 6.244

  10 in total

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