| Literature DB >> 33293339 |
Lewis F Buss1, Carlos A Prete2, Claudia M M Abrahim3, Alfredo Mendrone4,5, Tassila Salomon6,7, Cesar de Almeida-Neto4,5, Rafael F O França8, Maria C Belotti2, Maria P S S Carvalho3, Allyson G Costa3, Myuki A E Crispim3, Suzete C Ferreira4,5, Nelson A Fraiji3, Susie Gurzenda9, Charles Whittaker10, Leonardo T Kamaura11, Pedro L Takecian11, Pedro da Silva Peixoto11, Marcio K Oikawa12, Anna S Nishiya4,5, Vanderson Rocha4,5, Nanci A Salles4, Andreza Aruska de Souza Santos13, Martirene A da Silva3, Brian Custer14,15, Kris V Parag16, Manoel Barral-Netto17, Moritz U G Kraemer18, Rafael H M Pereira19, Oliver G Pybus18, Michael P Busch14,15, Márcia C Castro9, Christopher Dye18, Vítor H Nascimento2, Nuno R Faria20,16,18, Ester C Sabino20.
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spread rapidly in Manaus, the capital of Amazonas state in northern Brazil. The attack rate there is an estimate of the final size of the largely unmitigated epidemic that occurred in Manaus. We use a convenience sample of blood donors to show that by June 2020, 1 month after the epidemic peak in Manaus, 44% of the population had detectable immunoglobulin G (IgG) antibodies. Correcting for cases without a detectable antibody response and for antibody waning, we estimate a 66% attack rate in June, rising to 76% in October. This is higher than in São Paulo, in southeastern Brazil, where the estimated attack rate in October was 29%. These results confirm that when poorly controlled, COVID-19 can infect a large proportion of the population, causing high mortality.Entities:
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Year: 2020 PMID： 33293339 PMCID： PMC7857406 DOI： 10.1126/science.abe9728
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728