Literature DB >> 33923054

COVID-19 Vaccines: A Review of the Safety and Efficacy of Current Clinical Trials.

Zhi-Peng Yan1, Ming Yang2, Ching-Lung Lai1.   

Abstract

Various strategies have been designed to contain the COVID-19 pandemic. Among them, vaccine development is high on the agenda in spite of the unknown duration of the protection time. Various vaccines have been under clinical trials with promising results in different countries. The protective efficacy and the short-term and long-term side effects of the vaccines are of major concern. Therefore, comparing the protective efficacy and risks of vaccination is essential for the global control of COVID-19 through herd immunity. This study reviews the most recent data of 12 vaccines to evaluate their efficacy, safety profile and usage in various populations.

Entities:  

Keywords:  COVID-19; efficacy; herd immunity; safety; vaccine

Year:  2021        PMID： 33923054     DOI： 10.3390/ph14050406

Source DB:  PubMed          Journal:  Pharmaceuticals (Basel)        ISSN： 1424-8247


  52 in total

1.  Covid-19: Novavax vaccine efficacy is 86% against UK variant and 60% against South African variant.

Authors:  Elisabeth Mahase
Journal:  BMJ       Date:  2021-02-01

Review 2.  Prevention and management of COVID-19 among patients with diabetes: an appraisal of the literature.

Authors:  Prasad Katulanda; Harsha A Dissanayake; Ishara Ranathunga; Vithiya Ratnasamy; Piyumi S A Wijewickrama; Nilukshana Yogendranathan; Kavinga K K Gamage; Nipun L de Silva; Manilka Sumanatilleke; Noel P Somasundaram; David R Matthews
Journal:  Diabetologia       Date:  2020-05-14       Impact factor: 10.122

Review 3.  Molecular mechanisms for enhanced DNA vaccine immunogenicity.

Authors:  Lei Li; Nikolai Petrovsky
Journal:  Expert Rev Vaccines       Date:  2015-12-28       Impact factor: 5.217

4.  Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial.

Authors:  Pedro M Folegatti; Katie J Ewer; Parvinder K Aley; Brian Angus; Stephan Becker; Sandra Belij-Rammerstorfer; Duncan Bellamy; Sagida Bibi; Mustapha Bittaye; Elizabeth A Clutterbuck; Christina Dold; Saul N Faust; Adam Finn; Amy L Flaxman; Bassam Hallis; Paul Heath; Daniel Jenkin; Rajeka Lazarus; Rebecca Makinson; Angela M Minassian; Katrina M Pollock; Maheshi Ramasamy; Hannah Robinson; Matthew Snape; Richard Tarrant; Merryn Voysey; Catherine Green; Alexander D Douglas; Adrian V S Hill; Teresa Lambe; Sarah C Gilbert; Andrew J Pollard
Journal:  Lancet       Date:  2020-07-20       Impact factor: 79.321

Review 5.  A Comparison of Plasmid DNA and mRNA as Vaccine Technologies.

Authors:  Margaret A Liu
Journal:  Vaccines (Basel)       Date:  2019-04-24

6.  Thrombotic Thrombocytopenia after ChAdOx1 nCov-19 Vaccination.

Authors:  Andreas Greinacher; Thomas Thiele; Theodore E Warkentin; Karin Weisser; Paul A Kyrle; Sabine Eichinger
Journal:  N Engl J Med       Date:  2021-04-09       Impact factor: 91.245

7.  Phase I/II study of COVID-19 RNA vaccine BNT162b1 in adults.

Authors:  Mark J Mulligan; Kirsten E Lyke; Nicholas Kitchin; Judith Absalon; Alejandra Gurtman; Stephen Lockhart; Kathleen Neuzil; Vanessa Raabe; Ruth Bailey; Kena A Swanson; Ping Li; Kenneth Koury; Warren Kalina; David Cooper; Camila Fontes-Garfias; Pei-Yong Shi; Özlem Türeci; Kristin R Tompkins; Edward E Walsh; Robert Frenck; Ann R Falsey; Philip R Dormitzer; William C Gruber; Uğur Şahin; Kathrin U Jansen
Journal:  Nature       Date:  2020-08-12       Impact factor: 69.504

Review 8.  Impact of COVID-19 on the Cardiovascular System: A Review of Available Reports.

Authors:  R S Soumya; T Govindan Unni; K G Raghu
Journal:  Cardiovasc Drugs Ther       Date:  2020-09-14       Impact factor: 3.727

9.  Immunogenicity and safety of a recombinant adenovirus type-5-vectored COVID-19 vaccine in healthy adults aged 18 years or older: a randomised, double-blind, placebo-controlled, phase 2 trial.

Authors:  Feng-Cai Zhu; Xu-Hua Guan; Yu-Hua Li; Jian-Ying Huang; Tao Jiang; Li-Hua Hou; Jing-Xin Li; Bei-Fang Yang; Ling Wang; Wen-Juan Wang; Shi-Po Wu; Zhao Wang; Xiao-Hong Wu; Jun-Jie Xu; Zhe Zhang; Si-Yue Jia; Bu-Sen Wang; Yi Hu; Jing-Jing Liu; Jun Zhang; Xiao-Ai Qian; Qiong Li; Hong-Xing Pan; Hu-Dachuan Jiang; Peng Deng; Jin-Bo Gou; Xue-Wen Wang; Xing-Huan Wang; Wei Chen
Journal:  Lancet       Date:  2020-07-20       Impact factor: 202.731
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  46 in total

Review 1.  Consecutive Hits of COVID-19 in India: The Mystery of Plummeting Cases and Current Scenario.

Authors:  T K Suvvari; C P; S Kuppili; V Kandi; L V S Kutikuppala; V D K Kandula; S Mishra; A K Sarangi; R K Mohapatra; K Dhama
Journal:  Arch Razi Inst       Date:  2021-11-30

2.  Sequelae of COVID-19 among previously hospitalized patients up to 1 year after discharge: a systematic review and meta-analysis.

Authors:  Tianqi Yang; Michael Zhipeng Yan; Xingyi Li; Eric H Y Lau
Journal:  Infection       Date:  2022-06-24       Impact factor: 7.455

3.  Thyroid Inconveniences With Vaccination Against SARS-CoV-2: The Size of the Matter. A Systematic Review.

Authors:  Verdiana Caironi; Fabián Pitoia; Pierpaolo Trimboli
Journal:  Front Endocrinol (Lausanne)       Date:  2022-06-23       Impact factor: 6.055

Review 4.  Biomedical Applications of Quantum Dots: Overview, Challenges, and Clinical Potential.

Authors:  Ahmed A H Abdellatif; Mahmoud A Younis; Mansour Alsharidah; Osamah Al Rugaie; Hesham M Tawfeek
Journal:  Int J Nanomedicine       Date:  2022-05-02

5.  Recommendation and Roadmap of Mass Vaccination against Coronavirus Disease 2019 Pandemic in Bangladesh as a Lower-Middle-Income Country.

Authors:  M J Hossain; S M A Rahman; T B Emran; S Mitra; M R Islam; K Dhama
Journal:  Arch Razi Inst       Date:  2021-12-30

Review 6.  Addressing Vaccine-Induced Immune Thrombotic Thrombocytopenia (VITT) Following COVID-19 Vaccination: A Mini-Review of Practical Strategies.

Authors:  Po-Wei Chen; Zong-Yun Tsai; Ting-Hsing Chao; Yi-Heng Li; Charles Jia-Yin Hou; Ping-Yen Liu
Journal:  Acta Cardiol Sin       Date:  2021-07       Impact factor: 2.672

7.  Intranasal Vaccination Strategy to Control the COVID-19 Pandemic from a Veterinary Medicine Perspective.

Authors:  Salleh Annas; Mohd Zamri-Saad
Journal:  Animals (Basel)       Date:  2021-06-24       Impact factor: 2.752

8.  Antibody responses after two doses of CoronaVac of the participants with or without the diagnosis of COVID-19.

Authors:  Derya Ozturk; Nesrin Gareayaghi; Ceren Atasoy Tahtasakal; Mustafa Calik; Ertugrul Altinbilek
Journal:  Ir J Med Sci       Date:  2022-01-10       Impact factor: 1.568

9.  Efficacy and safety of an inactivated whole-virion SARS-CoV-2 vaccine (CoronaVac): interim results of a double-blind, randomised, placebo-controlled, phase 3 trial in Turkey.

Authors:  Mine Durusu Tanriover; Hamdi Levent Doğanay; Murat Akova; Hatice Rahmet Güner; Alpay Azap; Sıla Akhan; Şükran Köse; Fatma Şebnem Erdinç; Emin Halis Akalın; Ömer Fehmi Tabak; Hüsnü Pullukçu; Özgür Batum; Serap Şimşek Yavuz; Özge Turhan; Mustafa Taner Yıldırmak; İftihar Köksal; Yeşim Taşova; Volkan Korten; Gürdal Yılmaz; Mustafa Kemal Çelen; Sedat Altın; İlhami Çelik; Yaşar Bayındır; İlkay Karaoğlan; Aydın Yılmaz; Aykut Özkul; Hazal Gür; Serhat Unal
Journal:  Lancet       Date:  2021-07-08       Impact factor: 79.321

Review 10.  COVID-19: Unmasking Emerging SARS-CoV-2 Variants, Vaccines and Therapeutic Strategies.

Authors:  Renuka Raman; Krishna J Patel; Kishu Ranjan
Journal:  Biomolecules       Date:  2021-07-06
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