Literature DB >> 3329040

Alkylation mutagenesis in Saccharomyces cerevisiae: lack of evidence for an adaptive response.

R Polakowska1, G Perozzi, L Prakash.   

Abstract

We have found no evidence for an adaptive response for either lethality or mutagenesis following treatment of Saccharomyces cerevisiae with N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). The rad6 and rad52 mutants of S. cerevisiae are highly defective in MNNG and ethyl methanesulfonate induced mutagenesis of both stationary and exponential phase cells. These and other observations indicate that the mechanisms of repair of alkylation damage and mutagenesis differ markedly between S. cerevisiae and Escherichia coli.

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Year:  1986        PMID： 3329040     DOI： 10.1007/bf00410912

Source DB:  PubMed          Journal:  Curr Genet        ISSN： 0172-8083            Impact factor:   3.886


  28 in total

1.  Methyl phosphotriesters in alkylated DNA are repaired by the Ada regulatory protein of E. coli.

Authors:  T V McCarthy; T Lindahl
Journal:  Nucleic Acids Res       Date:  1985-04-25       Impact factor: 16.971

2.  Purification and partial characterization of -factor, a mating-type specific inhibitor of cell reproduction from Saccharomyces cerevisiae.

Authors:  W Duntze; D Stötzler; E Bücking-Throm; S Kalbitzer
Journal:  Eur J Biochem       Date:  1973-06

3.  Repair of O6-methylguanine in adapted Escherichia coli.

Authors:  P F Schendel; P E Robins
Journal:  Proc Natl Acad Sci U S A       Date:  1978-12       Impact factor: 11.205

4.  Temporal order in yeast chromosome replication.

Authors:  W Burke; W L Fangman
Journal:  Cell       Date:  1975-07       Impact factor: 41.582

5.  Induction of a DNA glycosylase for N-methylated purines is part of the adaptive response to alkylating agents.

Authors:  P Karran; T Hjelmgren; T Lindahl
Journal:  Nature       Date:  1982-04-22       Impact factor: 49.962

6.  Adaptation to alkylation resistance involves the induction of a DNA glycosylase.

Authors:  G Evensen; E Seeberg
Journal:  Nature       Date:  1982-04-22       Impact factor: 49.962

7.  The nucleotide sequence of the HIS4 region of yeast.

Authors:  T F Donahue; P J Farabaugh; G R Fink
Journal:  Gene       Date:  1982-04       Impact factor: 3.688

8.  Role of DNA repair in ethyl methanesulfonate-induced mutagenesis in Saccharomyces cerevisiae.

Authors:  L Prakash; D Higgins
Journal:  Carcinogenesis       Date:  1982       Impact factor: 4.944

9.  Lack of chemically induced mutation in repair-deficient mutants of yeast.

Authors:  L Prakash
Journal:  Genetics       Date:  1974-12       Impact factor: 4.562

10.  Inducible repair of O-alkylated DNA pyrimidines in Escherichia coli.

Authors:  T V McCarthy; P Karran; T Lindahl
Journal:  EMBO J       Date:  1984-03       Impact factor: 11.598
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  10 in total

Review 1.  How heterologously expressed Escherichia coli genes contribute to understanding DNA repair processes in Saccharomyces cerevisiae.

Authors:  Jela Brozmanová; Viera Vlcková; Miroslav Chovanec
Journal:  Curr Genet       Date:  2004-11-13       Impact factor: 3.886

2.  Repair of alkylation damage in Saccharomyces cerevisiae.

Authors:  R Goth-Goldstein; P L Johnson
Journal:  Mol Gen Genet       Date:  1990-05

3.  An adaptive response to alkylating agents in Aspergillus nidulans.

Authors:  P Hooley; S G Shawcross; P Strike
Journal:  Curr Genet       Date:  1988-11       Impact factor: 3.886

4.  A weak adaptive response to alkylation damage in Salmonella typhimurium.

Authors:  P Vaughan; B Sedgwick
Journal:  J Bacteriol       Date:  1991-06       Impact factor: 3.490

5.  Expression of the E.coli ada gene in yeast protects against the toxic and mutagenic effects of N-methyl-N'-nitro-N-nitrosoguanidine.

Authors:  J Brozmanova; K Kleibl; V Vlckova; M Skorvaga; L Cernakova; G P Margison
Journal:  Nucleic Acids Res       Date:  1990-01-25       Impact factor: 16.971

6.  Roles of Rev1, Pol zeta, Pol32 and Pol eta in the bypass of chromosomal abasic sites in Saccharomyces cerevisiae.

Authors:  Paul A Auerbach; Bruce Demple
Journal:  Mutagenesis       Date:  2009-11-09       Impact factor: 3.000

7.  Induction of S.cerevisiae MAG 3-methyladenine DNA glycosylase transcript levels in response to DNA damage.

Authors:  J Chen; L Samson
Journal:  Nucleic Acids Res       Date:  1991-12-11       Impact factor: 16.971

8.  UV-induced mutability in repair-deficient rad6-1 strains of Saccharomyces cerevisiae is caused by a suppressor gene.

Authors:  V Vlcková; Z Zuffová; J Brozmanová
Journal:  Folia Microbiol (Praha)       Date:  1992       Impact factor: 2.099

9.  Saccharomyces cerevisiae 3-methyladenine DNA glycosylase has homology to the AlkA glycosylase of E. coli and is induced in response to DNA alkylation damage.

Authors:  J Chen; B Derfler; L Samson
Journal:  EMBO J       Date:  1990-12       Impact factor: 11.598

10.  Molecular characterization of an adaptive response to alkylating agents in the opportunistic pathogen Aspergillus fumigatus.

Authors:  Karen A O'Hanlon; Geoffrey P Margison; Amy Hatch; David A Fitzpatrick; Rebecca A Owens; Sean Doyle; Gary W Jones
Journal:  Nucleic Acids Res       Date:  2012-06-04       Impact factor: 16.971
  10 in total

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