Literature DB >> 7046978

Role of DNA repair in ethyl methanesulfonate-induced mutagenesis in Saccharomyces cerevisiae.

L Prakash, D Higgins.   

Abstract

Ethyl methanesulfonate (EMS)-induced reversion of two sites which revert preferentially by GC to AT transitions, cycl-131 and cycl-115, has been examined in readiation sensitive, rad, mutants of yeast belonging to the rad52 epistasis group. The rad50, rad51, rad52, rad54 and rad56 mutants showed reducted reversion of both tester sites when stationary phase diploid cells were treated with EMS. No correlation was found between EMS-induced reversion and EMS-induced homologous mitotic intragenic recombination. Survival of rad6 rad52 double mutants following EMS treatment indicates that there is one epistasis group for the repair of EMS-induced lethal damage in yeast. A model involving misrepair mutagenesis of specific lesions is proposed to account for the experimental results.

Entities:  

Mesh：

Substances：

Year:  1982        PMID： 7046978     DOI： 10.1093/carcin/3.4.439

Source DB:  PubMed          Journal:  Carcinogenesis        ISSN： 0143-3334            Impact factor:   4.944


  10 in total

1.  Mutagenic DNA repair in Streptomyces.

Authors:  J Stonesifer; R H Baltz
Journal:  Proc Natl Acad Sci U S A       Date:  1985-02       Impact factor: 11.205

2.  Alkylation mutagenesis in Saccharomyces cerevisiae: lack of evidence for an adaptive response.

Authors:  R Polakowska; G Perozzi; L Prakash
Journal:  Curr Genet       Date:  1986       Impact factor: 3.886

3.  A complex pattern of sensitivity to simple monofunctional alkylating agents exists amongst the rad mutants of Saccharomyces cerevisiae.

Authors:  A J Cooper; R Waters
Journal:  Mol Gen Genet       Date:  1987-08

4.  DNA repair dependence of somatic mutagenesis of transposon-caused white alleles in Drosophila melanogaster after treatment with alkylating agents.

Authors:  K Fujikawa; S Kondo
Journal:  Genetics       Date:  1986-03       Impact factor: 4.562

5.  The genome-wide rate and spectrum of EMS-induced heritable mutations in the microcrustacean Daphnia: on the prospect of forward genetics.

Authors:  Marelize Snyman; Trung V Huynh; Matthew T Smith; Sen Xu
Journal:  Heredity (Edinb)       Date:  2021-10-19       Impact factor: 3.821

6.  The isolation and characterization of ngm2, a mutation that affects nitrosoguanidine mutagenesis in yeast.

Authors:  P E Nisson; C W Lawrence
Journal:  Mol Gen Genet       Date:  1986-07

7.  Yeast RNC1 encodes a chimeric protein, RhoNUC, with a human rho motif and deoxyribonuclease activity.

Authors:  T Y Chow; E L Perkins; M A Resnick
Journal:  Nucleic Acids Res       Date:  1992-10-11       Impact factor: 16.971

8.  Mutagenic and error-free DNA repair in Streptomyces.

Authors:  R H Baltz; J Stonesifer
Journal:  Mol Gen Genet       Date:  1985

9.  An endo-exonuclease activity of yeast that requires a functional RAD52 gene.

Authors:  T Y Chow; M A Resnick
Journal:  Mol Gen Genet       Date:  1988-01

10.  Non-recombinogenic roles for Rad52 in translesion synthesis during DNA damage tolerance.

Authors:  María I Cano-Linares; Aurora Yáñez-Vilches; Néstor García-Rodríguez; Marta Barrientos-Moreno; Román González-Prieto; Pedro San-Segundo; Helle D Ulrich; Félix Prado
Journal:  EMBO Rep       Date:  2020-12-02       Impact factor: 9.071
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.