Literature DB >> 6370685

Inducible repair of O-alkylated DNA pyrimidines in Escherichia coli.

T V McCarthy, P Karran, T Lindahl.   

Abstract

The three miscoding alkylated pyrimidines O2-methylcytosine, O2-methylthymine and O4-methylthymine are specifically recognized by Escherichia coli DNA repair enzymes. The activities are induced as part of the adaptive response to alkylating agents. O2-Methylcytosine and O2-methylthymine are removed by a DNA glycosylase, the alkA+ gene product, which also acts on N3-methylated purines. O4-Methylthymine is repaired by a methyltransferase, previously known to correct O6-methylguanine by transfer of the methyl group to one of its own cysteine residues. It is proposed that certain common structural features of the various methylated bases allow each of the two inducible repair enzymes to recognize and remove several different kinds of lesions from alkylated DNA.

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Year:  1984        PMID： 6370685      PMCID： PMC557384          DOI： 10.1002/j.1460-2075.1984.tb01844.x

Source DB:  PubMed          Journal:  EMBO J        ISSN： 0261-4189            Impact factor:   11.598


  31 in total

1.  Adaptive response to alkylating agents involves alteration in situ of O6-methylguanine residues in DNA.

Authors:  P Karran; T Lindahl; B Griffin
Journal:  Nature       Date:  1979-07-05       Impact factor: 49.962

2.  O2- and O4-alkyl pyrimidine nucleosides: stability of the glycosyl bond and of the alkyl group as a function of pH.

Authors:  B Singer; M Kröger; M Carrano
Journal:  Biochemistry       Date:  1978-04-04       Impact factor: 3.162

3.  A new pathway for DNA repair in Escherichia coli.

Authors:  L Samson; J Cairns
Journal:  Nature       Date:  1977-05-19       Impact factor: 49.962

4.  DNA N-glycosidases: properties of uracil-DNA glycosidase from Escherichia coli.

Authors:  T Lindahl; S Ljungquist; W Siegert; B Nyberg; B Sperens
Journal:  J Biol Chem       Date:  1977-05-25       Impact factor: 5.157

5.  Reaction of DNA with alkylating agents. Quantitation of alkylation by ethylnitrosourea of oxygen and nitrogen sites on poly[dA-dT] including phosphotriester formation.

Authors:  D E Jensen; D J Reed
Journal:  Biochemistry       Date:  1978-11-28       Impact factor: 3.162

6.  Enzymatic excision of free hypoxanthine from polydeoxynucleotides and DNA containing deoxyinosine monophosphate residues.

Authors:  P Karran; T Lindahl
Journal:  J Biol Chem       Date:  1978-09-10       Impact factor: 5.157

7.  All oxygens in nucleic acids react with carcinogenic ethylating agents.

Authors:  B Singer
Journal:  Nature       Date:  1976-11-25       Impact factor: 49.962

8.  A comprehensive quantitative analysis of methylated and ethylated DNA using high pressure liquid chromatography.

Authors:  D T Beranek; C C Weis; D H Swenson
Journal:  Carcinogenesis       Date:  1980-07       Impact factor: 4.944

9.  Removal of minor methylation products 7-methyladenine and 3-methylguanine from DNA of Escherichia coli treated with dimethyl sulphate.

Authors:  P D Lawley; W Warren
Journal:  Chem Biol Interact       Date:  1976-02       Impact factor: 5.192

10.  Reaction products from N-methyl-N-nitrosourea and deoxyribonucleic acid containing thymidine residues. Synthesis and identification of a new methylation product, O4-methylthymidine.

Authors:  P D Lawley; D J Orr; S A Shah; P B Farmer; M Jarman
Journal:  Biochem J       Date:  1973-09       Impact factor: 3.857
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  77 in total

1.  Crystal structures of 3-methyladenine DNA glycosylase MagIII and the recognition of alkylated bases.

Authors:  Brandt F Eichman; Eyleen J O'Rourke; J Pablo Radicella; Tom Ellenberger
Journal:  EMBO J       Date:  2003-10-01       Impact factor: 11.598

2.  Regulatory elements for expression of the alkA gene in response to alkylating agents.

Authors:  M Furuichi; C G Yu; M Anai; K Sakumi; M Sekiguchi
Journal:  Mol Gen Genet       Date:  1992-12

3.  Characterisation and nucleotide sequence of ogt, the O6-alkylguanine-DNA-alkyltransferase gene of E. coli.

Authors:  P M Potter; M C Wilkinson; J Fitton; F J Carr; J Brennand; D P Cooper; G P Margison
Journal:  Nucleic Acids Res       Date:  1987-11-25       Impact factor: 16.971

4.  DNA damage recognition and repair by 3-methyladenine DNA glycosylase I (TAG).

Authors:  Audrey H Metz; Thomas Hollis; Brandt F Eichman
Journal:  EMBO J       Date:  2007-04-05       Impact factor: 11.598

5.  Molecular analysis of Bacillus subtilis ada mutants deficient in the adaptive response to simple alkylating agents.

Authors:  F Morohoshi; K Hayashi; N Munakata
Journal:  J Bacteriol       Date:  1991-12       Impact factor: 3.490

6.  Discrimination of lesion removal of N-methylpurine-DNA glycosylase revealed by a potent neutralizing monoclonal antibody.

Authors:  Sanjay Adhikari; Stephen J Kennel; Gargi Roy; Partha S Mitra; Sankar Mitra; Rabindra Roy
Journal:  DNA Repair (Amst)       Date:  2007-09-04

7.  Induction of transversion mutations in Escherichia coli by N-methyl-N'-nitro-N-nitrosoguanidine is SOS dependent.

Authors:  P L Foster; E Eisenstadt
Journal:  J Bacteriol       Date:  1985-07       Impact factor: 3.490

8.  Adaptive response and enhancement of N-methyl-N'-nitro-N-nitrosoguanidine mutagenesis by chloramphenicol in Streptomyces fradiae.

Authors:  R H Baltz; J Stonesifer
Journal:  J Bacteriol       Date:  1985-11       Impact factor: 3.490

9.  DNA glycosylase enzymes induced during chemical adaptation of M. luteus.

Authors:  S Riazuddin; A Athar; Z Ahmed; S M Lali; A Sohail
Journal:  Nucleic Acids Res       Date:  1987-08-25       Impact factor: 16.971

10.  Separation of the SOS-dependent and SOS-independent components of alkylating-agent mutagenesis.

Authors:  L B Couto; I Chaudhuri; B A Donahue; B Demple; J M Essigmann
Journal:  J Bacteriol       Date:  1989-08       Impact factor: 3.490
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