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Literature DB >> 32980264

The Ground Zero of Organismal Life and Aging.

Abstract

Cells may naturally proceed or be forced to transition to a state with a radically lower biological age, that is, be rejuvenated. Examples are the conversion of somatic cells to induced pluripotent stem cells and rejuvenation of the germline with each generation. We posit that these processes converge to the same 'ground zero', the mid-embryonic state characterized by the lowest biological age where both organismal life and aging begin. It may also be related to the phylotypic state. The ground zero model clarifies the relationship between aging, development, rejuvenation, and de-differentiation, which are distinct throughout life. By extending the rejuvenation phase during early embryogenesis and editing the genome, it may be possible to achieve the biological age at the ground zero lower than that achieved naturally.

Entities: Chemical

Keywords: aging; biological age; development; ground zero; lifespan; rejuvenation

Mesh：

Year: 2020 PMID： 32980264 PMCID： PMC9183202 DOI： 10.1016/j.molmed.2020.08.012

Source DB: PubMed Journal: Trends Mol Med ISSN： 1471-4914 Impact factor: 15.272

41 in total

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Journal: Lancet Date: 2003-08-30 Impact factor: 79.321

2. Adopt a moratorium on heritable genome editing.

Authors: Eric S Lander; Françoise Baylis; Feng Zhang; Emmanuelle Charpentier; Paul Berg; Catherine Bourgain; Bärbel Friedrich; J Keith Joung; Jinsong Li; David Liu; Luigi Naldini; Jing-Bao Nie; Renzong Qiu; Bettina Schoene-Seifert; Feng Shao; Sharon Terry; Wensheng Wei; Ernst-Ludwig Winnacker
Journal: Nature Date: 2019-03 Impact factor: 49.962

Review 3. Cross-kingdom comparison of the developmental hourglass.

Authors: Hajk-Georg Drost; Philipp Janitza; Ivo Grosse; Marcel Quint
Journal: Curr Opin Genet Dev Date: 2017-03-24 Impact factor: 5.578

4. Patterns of Aging Biomarkers, Mortality, and Damaging Mutations Illuminate the Beginning of Aging and Causes of Early-Life Mortality.

Authors: Elvira D Kinzina; Dmitriy I Podolskiy; Sergey E Dmitriev; Vadim N Gladyshev
Journal: Cell Rep Date: 2019-12-24 Impact factor: 9.423

5. Genome-wide methylation profiles reveal quantitative views of human aging rates.

Authors: Gregory Hannum; Justin Guinney; Ling Zhao; Li Zhang; Guy Hughes; SriniVas Sadda; Brandy Klotzle; Marina Bibikova; Jian-Bing Fan; Yuan Gao; Rob Deconde; Menzies Chen; Indika Rajapakse; Stephen Friend; Trey Ideker; Kang Zhang
Journal: Mol Cell Date: 2012-11-21 Impact factor: 17.970

6. On the Relationship of Protein and mRNA Dynamics in Vertebrate Embryonic Development.

Authors: Leonid Peshkin; Martin Wühr; Esther Pearl; Wilhelm Haas; Robert M Freeman; John C Gerhart; Allon M Klein; Marko Horb; Steven P Gygi; Marc W Kirschner
Journal: Dev Cell Date: 2015-11-09 Impact factor: 12.270

7. Ribosomal DNA harbors an evolutionarily conserved clock of biological aging.

Authors: Meng Wang; Bernardo Lemos
Journal: Genome Res Date: 2019-02-14 Impact factor: 9.043

Review 8. Aging: progressive decline in fitness due to the rising deleteriome adjusted by genetic, environmental, and stochastic processes.

Authors: Vadim N Gladyshev
Journal: Aging Cell Date: 2016-04-06 Impact factor: 9.304

9. Paternal germ line aging: DNA methylation age prediction from human sperm.

Authors: Timothy G Jenkins; Kenneth I Aston; Bradley Cairns; Andrew Smith; Douglas T Carrell
Journal: BMC Genomics Date: 2018-10-22 Impact factor: 3.969

10. Partial reprogramming induces a steady decline in epigenetic age before loss of somatic identity.

Authors: Nelly Olova; Daniel J Simpson; Riccardo E Marioni; Tamir Chandra
Journal: Aging Cell Date: 2018-11-18 Impact factor: 9.304

11 in total

1. Asynchronous, contagious and digital aging.

Authors: Thomas A Rando; Tony Wyss-Coray
Journal: Nat Aging Date: 2021-01-14

2. Meeting Report: Aging Research and Drug Discovery.

Authors: Esther Meron; Maria Thaysen; Suzanne Angeli; Adam Antebi; Nir Barzilai; Joseph A Baur; Simon Bekker-Jensen; Maria Birkisdottir; Evelyne Bischof; Jens Bruening; Anne Brunet; Abigail Buchwalter; Filipe Cabreiro; Shiqing Cai; Brian H Chen; Maria Ermolaeva; Collin Y Ewald; Luigi Ferrucci; Maria Carolina Florian; Kristen Fortney; Adam Freund; Anastasia Georgievskaya; Vadim N Gladyshev; David Glass; Tyler Golato; Vera Gorbunova; Jan Hoejimakers; Riekelt H Houtkooper; Sibylle Jager; Frank Jaksch; Georges Janssens; Martin Borch Jensen; Matt Kaeberlein; Gerard Karsenty; Peter de Keizer; Brian Kennedy; James L Kirkland; Michael Kjaer; Guido Kroemer; Kai-Fu Lee; Jean-Marc Lemaitre; David Liaskos; Valter D Longo; Yu-Xuan Lu; Michael R MacArthur; Andrea B Maier; Christina Manakanatas; Sarah J Mitchell; Alexey Moskalev; Laura Niedernhofer; Ivan Ozerov; Linda Partridge; Emmanuelle Passegué; Michael A Petr; James Peyer; Dina Radenkovic; Thomas A Rando; Suresh Rattan; Christian G Riedel; Lenhard Rudolph; Ruixue Ai; Manuel Serrano; Björn Schumacher; David A Sinclair; Ryan Smith; Yousin Suh; Pam Taub; Alexandre Trapp; Anne-Ulrike Trendelenburg; Dario Riccardo Valenzano; Kris Verburgh; Eric Verdin; Jan Vijg; Rudi G J Westendorp; Alessandra Zonari; Daniela Bakula; Alex Zhavoronkov; Morten Scheibye-Knudsen
Journal: Aging (Albany NY) Date: 2022-01-28 Impact factor: 5.682

The Ground Zero of Organismal Life and Aging.

Review 1. Twinning.

2. Adopt a moratorium on heritable genome editing.

Review 3. Cross-kingdom comparison of the developmental hourglass.

4. Patterns of Aging Biomarkers, Mortality, and Damaging Mutations Illuminate the Beginning of Aging and Causes of Early-Life Mortality.

5. Genome-wide methylation profiles reveal quantitative views of human aging rates.

6. On the Relationship of Protein and mRNA Dynamics in Vertebrate Embryonic Development.

7. Ribosomal DNA harbors an evolutionarily conserved clock of biological aging.

Review 8. Aging: progressive decline in fitness due to the rising deleteriome adjusted by genetic, environmental, and stochastic processes.

9. Paternal germ line aging: DNA methylation age prediction from human sperm.

10. Partial reprogramming induces a steady decline in epigenetic age before loss of somatic identity.

1. Asynchronous, contagious and digital aging.

2. Meeting Report: Aging Research and Drug Discovery.

Review 3. Integrating DNA Methylation Measures of Biological Aging into Social Determinants of Health Research.

4. Profiling epigenetic age in single cells.

Review 5. Making sense of the ageing methylome.

6. A toolkit for quantification of biological age from blood chemistry and organ function test data: BioAge.

7. Socioeconomic Disadvantage and the Pace of Biological Aging in Children.

Review 8. Emerging rejuvenation strategies-Reducing the biological age.

9. Searching for female reproductive aging and longevity biomarkers.

10. Epigenetic clocks reveal a rejuvenation event during embryogenesis followed by aging.