Fanny Orlhac1,2, Augustin Lecler3, Julien Savatovski3,4, Jessica Goya-Outi5, Christophe Nioche5, Frédérique Charbonneau3, Nicholas Ayache6, Frédérique Frouin5, Loïc Duron3, Irène Buvat5. 1. Laboratoire d'Imagerie Translationnelle en Oncologie (LITO), Inserm, Institut Curie Centre de Recherche, Université Paris-Saclay, Bât 101B, rue Henri Becquerel, 91401, Orsay, France. orlhacf@gmail.com. 2. Université Côte d'Azur, Inria Sophia Antipolis - Méditerranée, Epione Project Team, 2004 route des Lucioles, BP 93, 06902, Sophia Antipolis Cedex, France. orlhacf@gmail.com. 3. Department of Neuroradiology, Fondation Ophtalmologique A. Rothschild, 29 rue Manin, 75019, Paris, France. 4. Centre Imagerie Médicale Paris 13, 17 avenue d'Italie, 75013, Paris, France. 5. Laboratoire d'Imagerie Translationnelle en Oncologie (LITO), Inserm, Institut Curie Centre de Recherche, Université Paris-Saclay, Bât 101B, rue Henri Becquerel, 91401, Orsay, France. 6. Université Côte d'Azur, Inria Sophia Antipolis - Méditerranée, Epione Project Team, 2004 route des Lucioles, BP 93, 06902, Sophia Antipolis Cedex, France.
Abstract
OBJECTIVE: Test a practical realignment approach to compensate the technical variability of MR radiomic features. METHODS: T1 phantom images acquired on 2 scanners, FLAIR and contrast-enhanced T1-weighted (CE-T1w) images of 18 brain tumor patients scanned on both 1.5-T and 3-T scanners, and 36 T2-weighted (T2w) images of prostate cancer patients scanned in one of two centers were investigated. The ComBat procedure was used for harmonizing radiomic features. Differences in statistical distributions in feature values between 1.5- and 3-T images were tested before and after harmonization. The prostate studies were used to determine the impact of harmonization to distinguish between Gleason grades (GGs). RESULTS: In the phantom data, 40 out of 42 radiomic feature values were significantly different between the 2 scanners before harmonization and none after. In white matter regions, the statistical distributions of features were significantly different (p < 0.05) between the 1.5- and 3-T images for 37 out of 42 features in both FLAIR and CE-T1w images. After harmonization, no statistically significant differences were observed. In brain tumors, 41 (FLAIR) or 36 (CE-T1w) out of 42 features were significantly different between the 1.5- and 3-T images without harmonization, against 1 (FLAIR) or none (CE-T1w) with harmonization. In prostate studies, 636 radiomic features were significantly different between GGs after harmonization against 461 before. The ability to distinguish between GGs using radiomic features was increased after harmonization. CONCLUSION: ComBat harmonization efficiently removes inter-center technical inconsistencies in radiomic feature values and increases the sensitivity of studies using data from several scanners. KEY POINTS: • Radiomic feature values obtained using different MR scanners or imaging protocols can be harmonized by combining off-the-shelf image standardization and feature realignment procedures. • Harmonized radiomic features enable one to pool data from different scanners and centers without a substantial loss of statistical power caused by intra- and inter-center variability. • The proposed realignment method is applicable to radiomic features from different MR sequences and tumor types and does not rely on any phantom acquisition.
OBJECTIVE: Test a practical realignment approach to compensate the technical variability of MR radiomic features. METHODS: T1 phantom images acquired on 2 scanners, FLAIR and contrast-enhanced T1-weighted (CE-T1w) images of 18 brain tumorpatients scanned on both 1.5-T and 3-T scanners, and 36 T2-weighted (T2w) images of prostate cancerpatients scanned in one of two centers were investigated. The ComBat procedure was used for harmonizing radiomic features. Differences in statistical distributions in feature values between 1.5- and 3-T images were tested before and after harmonization. The prostate studies were used to determine the impact of harmonization to distinguish between Gleason grades (GGs). RESULTS: In the phantom data, 40 out of 42 radiomic feature values were significantly different between the 2 scanners before harmonization and none after. In white matter regions, the statistical distributions of features were significantly different (p < 0.05) between the 1.5- and 3-T images for 37 out of 42 features in both FLAIR and CE-T1w images. After harmonization, no statistically significant differences were observed. In brain tumors, 41 (FLAIR) or 36 (CE-T1w) out of 42 features were significantly different between the 1.5- and 3-T images without harmonization, against 1 (FLAIR) or none (CE-T1w) with harmonization. In prostate studies, 636 radiomic features were significantly different between GGs after harmonization against 461 before. The ability to distinguish between GGs using radiomic features was increased after harmonization. CONCLUSION: ComBat harmonization efficiently removes inter-center technical inconsistencies in radiomic feature values and increases the sensitivity of studies using data from several scanners. KEY POINTS: • Radiomic feature values obtained using different MR scanners or imaging protocols can be harmonized by combining off-the-shelf image standardization and feature realignment procedures. • Harmonized radiomic features enable one to pool data from different scanners and centers without a substantial loss of statistical power caused by intra- and inter-center variability. • The proposed realignment method is applicable to radiomic features from different MR sequences and tumor types and does not rely on any phantom acquisition.
Authors: Kathryn E Keenan; Jana G Delfino; Kalina V Jordanova; Megan E Poorman; Prathyush Chirra; Akshay S Chaudhari; Bettina Baessler; Jessica Winfield; Satish E Viswanath; Nandita M deSouza Journal: Med Phys Date: 2021-09-29 Impact factor: 4.506
Authors: Natalia Saltybaeva; Stephanie Tanadini-Lang; Diem Vuong; Simon Burgermeister; Michael Mayinger; Andrea Bink; Nicolaus Andratschke; Matthias Guckenberger; Marta Bogowicz Journal: Phys Imaging Radiat Oncol Date: 2022-05-14
Authors: Joshua Shur; Matthew Blackledge; James D'Arcy; David J Collins; Maria Bali; Martin O'Leach; Dow-Mu Koh Journal: Eur Radiol Exp Date: 2021-01-19