Jonathan D Harper1, Ian Metzler1, Michael Kennedy Hall2, Tony T Chen1, Adam D Maxwell1,3, Bryan W Cunitz3, Barbrina Dunmire3, Jeff Thiel3, James C Williams4, Michael R Bailey1,3, Mathew D Sorensen1,5. 1. Department of Urology and University of Washington School of Medicine, Seattle, Washington, USA. 2. Department of Emergency Medicine, University of Washington School of Medicine, Seattle, Washington, USA. 3. Center for Industrial and Medical Ultrasound, Applied Physics Laboratory, University of Washington, Seattle, Washington, USA. 4. Department of Anatomy, Cell Biology & Physiology, Indiana University School of Medicine, Indianapolis, Indiana, USA. 5. Division of Urology, VA Puget Sound Health Care System, Seattle, Washington, USA.
Abstract
Purpose: To test the effectiveness (Participant A) and tolerability (Participant B) of urinary stone comminution in the first-in-human trial of a new technology, burst-wave lithotripsy (BWL). Materials and Methods: An investigational BWL and ultrasonic propulsion system was used to target a 7-mm kidney stone in the operating room before ureteroscopy (Participant A). The same system was used to target a 7.5 mm ureterovesical junction stone in clinic without anesthesia (Participant B). Results: For Participant A, a ureteroscope inserted after 9 minutes of BWL observed fragmentation of the stone to <2 mm fragments. Participant B tolerated the procedure without pain from BWL, required no anesthesia, and passed the stone on day 15. Conclusions: The first-in-human tests of BWL pulses were successful in that a renal stone was comminuted in <10 minutes, and BWL was also tolerated by an awake subject for a distal ureteral stone. Clinical Trial NCT03873259 and NCT02028559.
Purpose: To test the effectiveness (Participant A) and tolerability (Participant B) of urinary stone comminution in the first-in-human trial of a new technology, burst-wave lithotripsy (BWL). Materials and Methods: An investigational BWL and ultrasonic propulsion system was used to target a 7-mm kidney stone in the operating room before ureteroscopy (Participant A). The same system was used to target a 7.5 mm ureterovesical junction stone in clinic without anesthesia (Participant B). Results: For Participant A, a ureteroscope inserted after 9 minutes of BWL observed fragmentation of the stone to <2 mm fragments. Participant B tolerated the procedure without pain from BWL, required no anesthesia, and passed the stone on day 15. Conclusions: The first-in-human tests of BWL pulses were successful in that a renal stone was comminuted in <10 minutes, and BWL was also tolerated by an awake subject for a distal ureteral stone. Clinical Trial NCT03873259 and NCT02028559.
Authors: Bryan W Cunitz; Jonathan D Harper; Mathew D Sorensen; Yasser A Haider; Jeff Thiel; Philip C May; Ziyue Liu; Michael R Bailey; Barbrina Dunmire; Matthew Bruce Journal: J Endourol Date: 2017-09-28 Impact factor: 2.942
Authors: Philip C May; Wayne Kreider; Adam D Maxwell; Yak-Nam Wang; Bryan W Cunitz; Philip M Blomgren; Cynthia D Johnson; Joshua S H Park; Michael R Bailey; Donghoon Lee; Jonathan D Harper; Mathew D Sorensen Journal: J Endourol Date: 2017-06-16 Impact factor: 2.942
Authors: Jessica C Dai; Mathew D Sorensen; Helena C Chang; Patrick C Samson; Barbrina Dunmire; Bryan W Cunitz; Jeff Thiel; Ziyue Liu; Michael R Bailey; Jonathan D Harper Journal: J Endourol Date: 2019-09-25 Impact factor: 2.942
Authors: Adam D Maxwell; Yak-Nam Wang; Wayne Kreider; Bryan W Cunitz; Frank Starr; Donghoon Lee; Yasser Nazari; James C Williams; Michael R Bailey; Mathew D Sorensen Journal: J Endourol Date: 2019-05-27 Impact factor: 2.942
Authors: Bret A Connors; Andrew P Evan; Philip M Blomgren; Ryan S Hsi; Jonathan D Harper; Mathew D Sorensen; Yak-Nam Wang; Julianna C Simon; Marla Paun; Frank Starr; Bryan W Cunitz; Michael R Bailey; James E Lingeman Journal: J Urol Date: 2013-08-02 Impact factor: 7.450
Authors: Michael R Bailey; Adam D Maxwell; Shunxiang Cao; Shivani Ramesh; Ziyue Liu; James C Williams; Jeff Thiel; Barbrina Dunmire; Tim Colonius; Ekaterina Kuznetsova; Wayne Kreider; Mathew D Sorensen; James E Lingeman; Oleg A Sapozhnikov Journal: J Endourol Date: 2022-06-22 Impact factor: 2.619
Authors: Jonathan D Harper; James E Lingeman; Robert M Sweet; Ian S Metzler; Peter L Sunaryo; James C Williams; Adam D Maxwell; Jeff Thiel; Bryan W Cunitz; Barbrina Dunmire; Michael R Bailey; Mathew D Sorensen Journal: J Urol Date: 2022-03-21 Impact factor: 7.600
Authors: Adam D Maxwell; Christopher Hunter; Bryan W Cunitz; Wayne Kreider; Stephanie Totten; Yak-Nam Wang Journal: Ultrasound Med Biol Date: 2021-05-31 Impact factor: 3.694