Literature DB >> 3290852

The core region of human glutaminyl-tRNA synthetase homologies with the Escherichia coli and yeast enzymes.

P Thömmes1, R Fett, B Schray, N Kunze, R Knippers.   

Abstract

We have isolated from a Lambda-gt 11 library a human cDNA clone with one open reading frame of about 2400 bases. A stretch of about 350 amino acids in the deduced amino acid sequence is up to 40 percent identical with parts of the known amino acid sequences of E. coli and yeast glutaminyl (Gln)-tRNA synthetase. The isolated cDNA sequence corresponds to an internal section of a 5500 bases long mRNA that codes for a 170 kDa polypeptide associated with Gln-tRNA synthetase. Thus, the human enzyme is about three times larger than the E. coli and two times larger than the yeast Gln-tRNA synthetase. The three enzymes share an evolutionarily conserved core but differ in amino acid sequences linked to the N-terminal and C-terminal side of the core.

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Year:  1988        PMID： 3290852      PMCID： PMC336774          DOI： 10.1093/nar/16.12.5391

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  31 in total

1.  Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

Authors:  H Towbin; T Staehelin; J Gordon
Journal:  Proc Natl Acad Sci U S A       Date:  1979-09       Impact factor: 11.205

2.  Magnesium precipitation of ribonucleoprotein complexes. Expedient techniques for the isolation of undergraded polysomes and messenger ribonucleic acid.

Authors:  R D Palmiter
Journal:  Biochemistry       Date:  1974-08-13       Impact factor: 3.162

3.  Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors:  U K Laemmli
Journal:  Nature       Date:  1970-08-15       Impact factor: 49.962

4.  Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose.

Authors:  P S Thomas
Journal:  Proc Natl Acad Sci U S A       Date:  1980-09       Impact factor: 11.205

5.  Transcription maps of polyoma virus-specific RNA: analysis by two-dimensional nuclease S1 gel mapping.

Authors:  J Favaloro; R Treisman; R Kamen
Journal:  Methods Enzymol       Date:  1980       Impact factor: 1.600

6.  Escherichia coli glutaminyl-tRNA synthetase. II. Characterization of the glnS gene product.

Authors:  P Hoben; N Royal; A Cheung; F Yamao; K Biemann; D Söll
Journal:  J Biol Chem       Date:  1982-10-10       Impact factor: 5.157

7.  HeLa cell DNA polymerase alpha is tightly associated with tryptophanyl-tRNA synthetase and diadenosine 5',5"'-P1,P4-tetraphosphate binding activities.

Authors:  E Rapaport; P C Zamecnik; E F Baril
Journal:  Proc Natl Acad Sci U S A       Date:  1981-02       Impact factor: 11.205

8.  The nucleotide sequence of the structural gene for Escherichia coli tryptophanyl-tRNA synthetase.

Authors:  C V Hall; M vanCleemput; K H Muench; C Yanofsky
Journal:  J Biol Chem       Date:  1982-06-10       Impact factor: 5.157

9.  DNA sequencing with chain-terminating inhibitors.

Authors:  F Sanger; S Nicklen; A R Coulson
Journal:  Proc Natl Acad Sci U S A       Date:  1977-12       Impact factor: 11.205

10.  Human DNA polymerase alpha gene expression is cell proliferation dependent and its primary structure is similar to both prokaryotic and eukaryotic replicative DNA polymerases.

Authors:  S W Wong; A F Wahl; P M Yuan; N Arai; B E Pearson; K Arai; D Korn; M W Hunkapiller; T S Wang
Journal:  EMBO J       Date:  1988-01       Impact factor: 11.598
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  7 in total

1.  Exons encoding the highly conserved part of human glutaminyl-tRNA synthetase.

Authors:  E Kaiser; D Eberhard; R Knippers
Journal:  J Mol Evol       Date:  1992-01       Impact factor: 2.395

2.  Binding of human glutaminyl-tRNA synthetase to a specific site of its mRNA.

Authors:  B Schray; R Knippers
Journal:  Nucleic Acids Res       Date:  1991-10-11       Impact factor: 16.971

3.  Localization of the active type I DNA topoisomerase gene on human chromosome 20q11.2-13.1, and two pseudogenes on chromosomes 1q23-24 and 22q11.2-13.1.

Authors:  N Kunze; G C Yang; Z Y Jiang; H Hameister; S Adolph; K H Wiedorn; A Richter; R Knippers
Journal:  Hum Genet       Date:  1989-12       Impact factor: 4.132

4.  The human QARS locus: assignment of the human gene for glutaminyl-tRNA synthetase to chromosome 1q32-42.

Authors:  N Kunze; E Bittler; R Fett; B Schray; H Hameister; K H Wiedorn; R Knippers
Journal:  Hum Genet       Date:  1990-10       Impact factor: 4.132

5.  Reaction of anti-OJ autoantibodies with components of the multi-enzyme complex of aminoacyl-tRNA synthetases in addition to isoleucyl-tRNA synthetase.

Authors:  I N Targoff; E P Trieu; F W Miller
Journal:  J Clin Invest       Date:  1993-06       Impact factor: 14.808

6.  Properties of the nuclear P1 protein, a mammalian homologue of the yeast Mcm3 replication protein.

Authors:  P Thömmes; R Fett; B Schray; R Burkhart; M Barnes; C Kennedy; N C Brown; R Knippers
Journal:  Nucleic Acids Res       Date:  1992-03-11       Impact factor: 16.971

7.  A component of the multisynthetase complex is a multifunctional aminoacyl-tRNA synthetase.

Authors:  C Cerini; P Kerjan; M Astier; D Gratecos; M Mirande; M Sémériva
Journal:  EMBO J       Date:  1991-12       Impact factor: 11.598
  7 in total

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