Literature DB >> 2558068

Localization of the active type I DNA topoisomerase gene on human chromosome 20q11.2-13.1, and two pseudogenes on chromosomes 1q23-24 and 22q11.2-13.1.

N Kunze1, G C Yang, Z Y Jiang, H Hameister, S Adolph, K H Wiedorn, A Richter, R Knippers.   

Abstract

Different subfragments of a cDNA coding for DNA topoisomerase I were used as probes to determine the chromosomal localization of topoisomerase I sequences in human cells. Southern blotting of restricted DNA from a panel of rodent-human somatic cell hybrids revealed the localization of the complete gene on chromosome 20 and the presence of two truncated topoisomerase I pseudogene sequences on chromosomes 1 and 22. In situ chromosome hybridization experiments confirmed these results showing the location of the complete gene on band q11.2-13.1 of chromosome 20, and the location of the pseudogene sequences on band q23-24 of chromosome 1 and q11.2-13.1 of chromosome 22.

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Year:  1989        PMID： 2558068     DOI： 10.1007/BF00210661

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  30 in total

1.  Loss of genes on chromosome 22 in tumorigenesis of human acoustic neuroma.

Authors:  B R Seizinger; R L Martuza; J F Gusella
Journal:  Nature       Date:  1986 Aug 14-20       Impact factor: 49.962

Review 2.  Recent studies of DNA topoisomerases.

Authors:  J C Wang
Journal:  Biochim Biophys Acta       Date:  1987-06-06

3.  Association of crossover points with topoisomerase I cleavage sites: a model for nonhomologous recombination.

Authors:  P Bullock; J J Champoux; M Botchan
Journal:  Science       Date:  1985-11-22       Impact factor: 47.728

4.  Monoclonal antibodies neutralizing mammalian DNA topoisomerase I activity.

Authors:  P Oddou; U Schmidt; R Knippers; A Richter
Journal:  Eur J Biochem       Date:  1988-11-15

5.  cDNA cloning of human DNA topoisomerase I: catalytic activity of a 67.7-kDa carboxyl-terminal fragment.

Authors:  P D'Arpa; P S Machlin; H Ratrie; N F Rothfield; D W Cleveland; W C Earnshaw
Journal:  Proc Natl Acad Sci U S A       Date:  1988-04       Impact factor: 11.205

6.  A highly polymorphic locus in human DNA.

Authors:  A R Wyman; R White
Journal:  Proc Natl Acad Sci U S A       Date:  1980-11       Impact factor: 11.205

7.  Role of DNA topoisomerase I in the transcription of supercoiled rRNA gene.

Authors:  L C Garg; S DiAngelo; S T Jacob
Journal:  Proc Natl Acad Sci U S A       Date:  1987-05       Impact factor: 11.205

8.  Roles of DNA topoisomerases in simian virus 40 DNA replication in vitro.

Authors:  L Yang; M S Wold; J J Li; T J Kelly; L F Liu
Journal:  Proc Natl Acad Sci U S A       Date:  1987-02       Impact factor: 11.205

9.  Camptothecin-induced in vivo topoisomerase I cleavages in the transcriptionally active tyrosine aminotransferase gene.

Authors:  A F Stewart; G Schütz
Journal:  Cell       Date:  1987-09-25       Impact factor: 41.582

10.  Deletion mapping of a locus on human chromosome 22 involved in the oncogenesis of meningioma.

Authors:  J P Dumanski; E Carlbom; V P Collins; M Nordenskjöld
Journal:  Proc Natl Acad Sci U S A       Date:  1987-12       Impact factor: 11.205
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  17 in total

1.  Scaffold/matrix attachment region elements interact with a p300-scaffold attachment factor A complex and are bound by acetylated nucleosomes.

Authors:  Joost H A Martens; Matty Verlaan; Eric Kalkhoven; Josephine C Dorsman; Alt Zantema
Journal:  Mol Cell Biol       Date:  2002-04       Impact factor: 4.272

2.  Cytogenetic alignment of the bovine chromosome 13 genome map by fluorescence in-situ hybridization of human chromosome 10 and 20 comparative markers.

Authors:  D S Gallagher; J Schläpfer; J D Burzlaff; J E Womack; D M Stelly; S K Davis; J F Taylor
Journal:  Chromosome Res       Date:  1999       Impact factor: 5.239

3.  A human immunoglobulin kappa orphon without sequence defects may be the product of a pericentric inversion.

Authors:  C Huber; R Thiebe; H Hameister; H Smola; E Lötscher; H G Zachau
Journal:  Nucleic Acids Res       Date:  1990-06-25       Impact factor: 16.971

4.  Assignment of casein kinase 2 alpha sequences to two different human chromosomes.

Authors:  B Boldyreff; C Klett; E Göttert; A Geurts van Kessel; H Hameister; O G Issinger
Journal:  Hum Genet       Date:  1992-04       Impact factor: 4.132

5.  A three allele TaqI polymorphism at TOP1 gene.

Authors:  L Sunde; E Kjeldsen; T Andoh; J D Keene; L Bolund
Journal:  Nucleic Acids Res       Date:  1990-10-11       Impact factor: 16.971

6.  Expression of the type I DNA topoisomerase gene in adenovirus-5 infected human cells.

Authors:  H Romig; A Richter
Journal:  Nucleic Acids Res       Date:  1990-02-25       Impact factor: 16.971

7.  The human QARS locus: assignment of the human gene for glutaminyl-tRNA synthetase to chromosome 1q32-42.

Authors:  N Kunze; E Bittler; R Fett; B Schray; H Hameister; K H Wiedorn; R Knippers
Journal:  Hum Genet       Date:  1990-10       Impact factor: 4.132

Review 8.  Novel actions of inhibitors of DNA topoisomerase II in drug-resistant tumor cells.

Authors:  W T Beck; R Kim; M Chen
Journal:  Cancer Chemother Pharmacol       Date:  1994       Impact factor: 3.333

9.  Molecular cloning of a cDNA of a camptothecin-resistant human DNA topoisomerase I and identification of mutation sites.

Authors:  H Tamura; C Kohchi; R Yamada; T Ikeda; O Koiwai; E Patterson; J D Keene; K Okada; E Kjeldsen; K Nishikawa
Journal:  Nucleic Acids Res       Date:  1991-01-11       Impact factor: 16.971

10.  The human topoisomerase I gene promoter is regulated by NF-IL6.

Authors:  S Heiland; R Knippers
Journal:  Mol Cell Biol       Date:  1995-12       Impact factor: 4.272
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