| Literature DB >> 32284552 |
Dylan J Richards1,2, Yang Li1, Charles M Kerr3, Jenny Yao1,4, Gyda C Beeson5, Robert C Coyle1, Xun Chen1, Jia Jia1, Brooke Damon1, Robert Wilson6, E Starr Hazard7, Gary Hardiman7,8,9, Donald R Menick10,11, Craig C Beeson5, Hai Yao1, Tong Ye12, Ying Mei13,14.
Abstract
Environmental factors are the largest contributors to cardiovascular disease. Here we show that cardiac organoids that incorporate an oxygen-diffusion gradient and that are stimulated with the neurotransmitter noradrenaline model the structure of the human heart after myocardial infarction (by mimicking the infarcted, border and remote zones), and recapitulate hallmarks of myocardial infarction (in particular, pathological metabolic shifts, fibrosis and calcium handling) at the transcriptomic, structural and functional levels. We also show that the organoids can model hypoxia-enhanced doxorubicin cardiotoxicity. Human organoids that model diseases with non-genetic pathological factors could help with drug screening and development.Entities:
Mesh：
Substances：
Year: 2020 PMID： 32284552 PMCID： PMC7422941 DOI： 10.1038/s41551-020-0539-4
Source DB: PubMed Journal: Nat Biomed Eng ISSN： 2157-846X Impact factor: 25.671