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Literature DB >> 28126704

CRISPR/Cas 9 genome editing and its applications in organoids.

Abstract

Organoids are three-dimensional (3D) structures derived from adult or embryonic stem cells that maintain many structural and functional features of their respective organ. Recently, genome editing based on the bacterial defense mechanism CRISPR/Cas9 has emerged as an easily applicable and reliable laboratory tool. Combining organoids and CRISPR/Cas9 creates exciting new opportunities to study organ development and human disease in vitro. The potential applications of CRISPR in organoids are only beginning to be explored.

Entities: Species

Keywords: CRISPR/Cas9; gene editing; organoid

Mesh：

Year: 2017 PMID： 28126704 DOI： 10.1152/ajpgi.00410.2016

Source DB: PubMed Journal: Am J Physiol Gastrointest Liver Physiol ISSN： 0193-1857 Impact factor: 4.052

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Cited

34 in total

Review 1. Reverse-engineering organogenesis through feedback loops between model systems.

Authors: Cody Narciso; Jeremiah Zartman
Journal: Curr Opin Biotechnol Date: 2017-12-21 Impact factor: 9.740

Review 2. Cell-based liver therapies: past, present and future.

Authors: Valeria Iansante; Anil Chandrashekran; Anil Dhawan
Journal: Philos Trans R Soc Lond B Biol Sci Date: 2018-07-05 Impact factor: 6.237

3. KRAS Activation in Gastric Adenocarcinoma Stimulates Epithelial-to-Mesenchymal Transition to Cancer Stem-Like Cells and Promotes Metastasis.

Authors: Changhwan Yoon; Jacob Till; Soo-Jeong Cho; Kevin K Chang; Jian-Xian Lin; Chang-Ming Huang; Sandra Ryeom; Sam S Yoon
Journal: Mol Cancer Res Date: 2019-06-19 Impact factor: 5.852

Review 4. Cardiac Organoids: A 3D Technology for Modeling Heart Development and Disease.

Authors: Liyuan Zhu; Kui Liu; Qi Feng; Yingnan Liao
Journal: Stem Cell Rev Rep Date: 2022-05-08 Impact factor: 5.739

5. Human cardiac organoids for the modelling of myocardial infarction and drug cardiotoxicity.

Authors: Dylan J Richards; Yang Li; Charles M Kerr; Jenny Yao; Gyda C Beeson; Robert C Coyle; Xun Chen; Jia Jia; Brooke Damon; Robert Wilson; E Starr Hazard; Gary Hardiman; Donald R Menick; Craig C Beeson; Hai Yao; Tong Ye; Ying Mei
Journal: Nat Biomed Eng Date: 2020-04-13 Impact factor: 25.671

6. KMT2C Mutations in Diffuse-Type Gastric Adenocarcinoma Promote Epithelial-to-Mesenchymal Transition.

Authors: Soo-Jeong Cho; Changhwan Yoon; Jun Ho Lee; Kevin K Chang; Jian-Xian Lin; Young-Ho Kim; Myeong-Cherl Kook; Bülent Arman Aksoy; Do Joong Park; Hassan Ashktorab; Duane T Smoot; Nikolaus Schultz; Sam S Yoon
Journal: Clin Cancer Res Date: 2018-08-14 Impact factor: 12.531

CRISPR/Cas 9 genome editing and its applications in organoids.

Review 1. Reverse-engineering organogenesis through feedback loops between model systems.

Review 2. Cell-based liver therapies: past, present and future.

3. KRAS Activation in Gastric Adenocarcinoma Stimulates Epithelial-to-Mesenchymal Transition to Cancer Stem-Like Cells and Promotes Metastasis.

Review 4. Cardiac Organoids: A 3D Technology for Modeling Heart Development and Disease.

5. Human cardiac organoids for the modelling of myocardial infarction and drug cardiotoxicity.

6. KMT2C Mutations in Diffuse-Type Gastric Adenocarcinoma Promote Epithelial-to-Mesenchymal Transition.

Review 7. Convergence of human pluripotent stem cell, organoid, and genome editing technologies.

Review 8. Cardiac organoid - a promising perspective of preclinical model.

Review 9. Understanding the cellular origin and progression of esophageal cancer using esophageal organoids.

Review 10. Recent Advances in Implantation-Based Genetic Modeling of Biliary Carcinogenesis in Mice.