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Literature DB >> 26911908

Organoids as an in vitro model of human development and disease.

Aliya Fatehullah¹, Si Hui Tan¹, Nick Barker^1,2,3.

Abstract

The in vitro organoid model is a major technological breakthrough that has already been established as an essential tool in many basic biology and clinical applications. This near-physiological 3D model facilitates an accurate study of a range of in vivo biological processes including tissue renewal, stem cell/niche functions and tissue responses to drugs, mutation or damage. In this Review, we discuss the current achievements, challenges and potential applications of this technique.

Entities: Species

Mesh：

Year: 2016 PMID： 26911908 DOI： 10.1038/ncb3312

Source DB: PubMed Journal: Nat Cell Biol ISSN： 1465-7392 Impact factor: 28.824

86 in total

1. Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5⁺ stem cell.

Authors: Shiro Yui; Tetsuya Nakamura; Toshiro Sato; Yasuhiro Nemoto; Tomohiro Mizutani; Xiu Zheng; Shizuko Ichinose; Takashi Nagaishi; Ryuichi Okamoto; Kiichiro Tsuchiya; Hans Clevers; Mamoru Watanabe
Journal: Nat Med Date: 2012-03-11 Impact factor: 53.440

2. Directing human embryonic stem cell differentiation towards a renal lineage generates a self-organizing kidney.

Authors: M Takasato; P X Er; M Becroft; J M Vanslambrouck; E G Stanley; A G Elefanty; M H Little
Journal: Nat Cell Biol Date: 2013-12-15 Impact factor: 28.824

Review 3. Materials as stem cell regulators.

Authors: William L Murphy; Todd C McDevitt; Adam J Engler
Journal: Nat Mater Date: 2014-06 Impact factor: 43.841

4. Development of intestinal organoids as tissue surrogates: cell composition and the epigenetic control of differentiation.

Authors: Li Cao; Anton Kuratnik; Wanli Xu; Jason D Gibson; Frederick Kolling; Eric R Falcone; Mohammed Ammar; Michael D Van Heyst; Dennis L Wright; Craig E Nelson; Charles Giardina
Journal: Mol Carcinog Date: 2013-09-21 Impact factor: 4.784

5. Lgr4 is required for Paneth cell differentiation and maintenance of intestinal stem cells ex vivo.

Authors: Roxana C Mustata; Tom Van Loy; Anne Lefort; Frédérick Libert; Sandra Strollo; Gilbert Vassart; Marie-Isabelle Garcia
Journal: EMBO Rep Date: 2011-04-21 Impact factor: 8.807

6. Identification of Lgr5-independent spheroid-generating progenitors of the mouse fetal intestinal epithelium.

Authors: Roxana C Mustata; Gabriela Vasile; Valeria Fernandez-Vallone; Sandra Strollo; Anne Lefort; Frédérick Libert; Daniel Monteyne; David Pérez-Morga; Gilbert Vassart; Marie-Isabelle Garcia
Journal: Cell Rep Date: 2013-10-17 Impact factor: 9.423

7. Prospective derivation of a living organoid biobank of colorectal cancer patients.

Authors: Marc van de Wetering; Hayley E Francies; Joshua M Francis; Gergana Bounova; Francesco Iorio; Apollo Pronk; Winan van Houdt; Joost van Gorp; Amaro Taylor-Weiner; Lennart Kester; Anne McLaren-Douglas; Joyce Blokker; Sridevi Jaksani; Sina Bartfeld; Richard Volckman; Peter van Sluis; Vivian S W Li; Sara Seepo; Chandra Sekhar Pedamallu; Kristian Cibulskis; Scott L Carter; Aaron McKenna; Michael S Lawrence; Lee Lichtenstein; Chip Stewart; Jan Koster; Rogier Versteeg; Alexander van Oudenaarden; Julio Saez-Rodriguez; Robert G J Vries; Gad Getz; Lodewyk Wessels; Michael R Stratton; Ultan McDermott; Matthew Meyerson; Mathew J Garnett; Hans Clevers
Journal: Cell Date: 2015-05-07 Impact factor: 41.582

8. Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro.

Authors: Jason R Spence; Christopher N Mayhew; Scott A Rankin; Matthew F Kuhar; Jefferson E Vallance; Kathryn Tolle; Elizabeth E Hoskins; Vladimir V Kalinichenko; Susanne I Wells; Aaron M Zorn; Noah F Shroyer; James M Wells
Journal: Nature Date: 2010-12-12 Impact factor: 49.962

9. Modelling human development and disease in pluripotent stem-cell-derived gastric organoids.

Authors: Kyle W McCracken; Emily M Catá; Calyn M Crawford; Katie L Sinagoga; Michael Schumacher; Briana E Rockich; Yu-Hwai Tsai; Christopher N Mayhew; Jason R Spence; Yana Zavros; James M Wells
Journal: Nature Date: 2014-10-29 Impact factor: 49.962

10. Transplantation of expanded fetal intestinal progenitors contributes to colon regeneration after injury.

Authors: Robert P Fordham; Shiro Yui; Nicholas R F Hannan; Christoffer Soendergaard; Alison Madgwick; Pawel J Schweiger; Ole H Nielsen; Ludovic Vallier; Roger A Pedersen; Tetsuya Nakamura; Mamoru Watanabe; Kim B Jensen
Journal: Cell Stem Cell Date: 2013-10-17 Impact factor: 24.633

423 in total

1. Generating Embryonic Salivary Gland Organoids.

Authors: Zeinab F Hosseini; Deirdre A Nelson; Nicholas Moskwa; Melinda Larsen
Journal: Curr Protoc Cell Biol Date: 2018-11-05

2. Magnetically Guided Self-Assembly and Coding of 3D Living Architectures.

Authors: Alessandro Tocchio; Naside Gozde Durmus; Kaushik Sridhar; Vigneshwaran Mani; Bukre Coskun; Rami El Assal; Utkan Demirci
Journal: Adv Mater Date: 2017-12-07 Impact factor: 30.849

3. Lineage Plasticity in Cancer Progression and Treatment.

Authors: Clémentine Le Magnen; Michael M Shen; Cory Abate-Shen
Journal: Annu Rev Cancer Biol Date: 2017-12-01

4. 3d Tissue Engineered In Vitro Models Of Cancer In Bone.

Authors: Anna M Sitarski; Heather Fairfield; Carolyne Falank; Michaela R Reagan
Journal: ACS Biomater Sci Eng Date: 2017-06-09

5. Tissue engineering toward organ-specific regeneration and disease modeling.

Authors: Christian Mandrycky; Kiet Phong; Ying Zheng
Journal: MRS Commun Date: 2017-07-31 Impact factor: 2.566

6. Human cardiac organoids for the modelling of myocardial infarction and drug cardiotoxicity.

Authors: Dylan J Richards; Yang Li; Charles M Kerr; Jenny Yao; Gyda C Beeson; Robert C Coyle; Xun Chen; Jia Jia; Brooke Damon; Robert Wilson; E Starr Hazard; Gary Hardiman; Donald R Menick; Craig C Beeson; Hai Yao; Tong Ye; Ying Mei
Journal: Nat Biomed Eng Date: 2020-04-13 Impact factor: 25.671

7. Guided self-organization and cortical plate formation in human brain organoids.

Authors: Madeline A Lancaster; Nina S Corsini; Simone Wolfinger; E Hilary Gustafson; Alex W Phillips; Thomas R Burkard; Tomoki Otani; Frederick J Livesey; Juergen A Knoblich
Journal: Nat Biotechnol Date: 2017-05-31 Impact factor: 54.908

8. Modeling the Early Steps of Ovarian Cancer Dissemination in an Organotypic Culture of the Human Peritoneal Cavity.

Authors: Peter C Hart; Preety Bajwa; Hilary A Kenny
Journal: Adv Exp Med Biol Date: 2021 Impact factor: 2.622

9. A Plug-and-Play, Drug-on-Pillar Platform for Combination Drug Screening Implemented by Microfluidic Adaptive Printing.

Authors: Jiannan Li; Wen Tan; Wenwu Xiao; Randy P Carney; Yongfan Men; Yuanpei Li; Gerald Quon; Yousif Ajena; Kit S Lam; Tingrui Pan
Journal: Anal Chem Date: 2018-11-13 Impact factor: 6.986

Review 10. Tissue engineered bone mimetics to study bone disorders ex vivo: Role of bioinspired materials.

Authors: Yuru Vernon Shih; Shyni Varghese
Journal: Biomaterials Date: 2018-06-06 Impact factor: 12.479