Literature DB >> 31988072

Biomarkers of Exposure among Adult Smokeless Tobacco Users in the Population Assessment of Tobacco and Health Study (Wave 1, 2013-2014).

Yu-Ching Cheng1, Carolyn M Reyes-Guzman2,3, Carol H Christensen2, Brian L Rostron2, Kathryn C Edwards4, Lanqing Wang5, Jun Feng5, Jeffery M Jarrett5, Cynthia D Ward5, Baoyun Xia5, Heather L Kimmel6, Kevin Conway6, Carmine Leggett2, Kristie Taylor4, Charlie Lawrence4, Ray Niaura7, Mark J Travers8, Andrew Hyland8, Stephen S Hecht9, Dorothy K Hatsukami9, Maciej L Goniewicz8, Nicolette Borek2, Benjamin C Blount5, Dana M van Bemmel2.   

Abstract

BACKGROUND: Monitoring population-level toxicant exposures from smokeless tobacco (SLT) use is important for assessing population health risks due to product use. In this study, we assessed tobacco biomarkers of exposure (BOE) among SLT users from the Wave 1 (2013-2014) of the Population Assessment of Tobacco and Health (PATH) Study.
METHODS: Urinary biospecimens were collected from adults ages 18 and older. Biomarkers of nicotine, tobacco-specific nitrosamines (TSNA), polycyclic aromatic hydrocarbons (PAH), volatile organic compounds (VOC), metals, and inorganic arsenic were analyzed and reported among exclusive current established SLT users in comparison with exclusive current established cigarette smokers, dual SLT and cigarette users, and never tobacco users.
RESULTS: In general, SLT users (n = 448) have significantly higher concentrations of BOE to nicotine, TSNAs, and PAHs compared with never tobacco users; significant dose-response relationships between frequency of SLT use and biomarker concentrations were also reported among exclusive SLT daily users. Exclusive SLT daily users have higher geometric mean concentrations of total nicotine equivalent-2 (TNE2) and TSNAs than exclusive cigarette daily smokers. In contrast, geometric mean concentrations of PAHs and VOCs were substantially lower among exclusive SLT daily users than exclusive cigarette daily smokers.
CONCLUSIONS: Our study produced a comprehensive assessment of SLT product use and 52 biomarkers of tobacco exposure. Compared with cigarette smokers, SLT users experience greater concentrations of some tobacco toxicants, including nicotine and TSNAs. IMPACT: Our data add information on the risk assessment of exposure to SLT-related toxicants. High levels of harmful constituents in SLT remain a health concern. ©2020 American Association for Cancer Research.

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Year:  2020        PMID： 31988072      PMCID： PMC7079166          DOI： 10.1158/1055-9965.EPI-19-0766

Source DB:  PubMed          Journal:  Cancer Epidemiol Biomarkers Prev        ISSN： 1055-9965            Impact factor:   4.254


  24 in total

1.  Sources of and technical approaches for the abatement of tobacco specific nitrosamine formation in moist smokeless tobacco products.

Authors:  Michael T Fisher; Cliff B Bennett; Alec Hayes; Yahya Kargalioglu; Brandy L Knox; Dongmei Xu; Raheema Muhammad-Kah; Charles L Gaworski
Journal:  Food Chem Toxicol       Date:  2011-11-28       Impact factor: 6.023

2.  Use of continine immunoassay test strips for preclassifying urine samples from smokers and nonsmokers prior to analysis by LC-MS-MS.

Authors:  John T Bernert; Tia L Harmon; Connie S Sosnoff; James E McGuffey
Journal:  J Anal Toxicol       Date:  2005 Nov-Dec       Impact factor: 3.367

3.  Quantitative analysis of five tobacco-specific N-nitrosamines in urine by liquid chromatography-atmospheric pressure ionization tandem mass spectrometry.

Authors:  Baoyun Xia; Yang Xia; Joshua Wong; Keegan J Nicodemus; Meng Xu; John Lee; Tonya Guillot; James Li
Journal:  Biomed Chromatogr       Date:  2013-10-11       Impact factor: 1.902

4.  Patterns of Use of Smokeless Tobacco in US Adults, 2013-2014.

Authors:  Yu-Ching Cheng; Brian L Rostron; Hannah R Day; Cassandra A Stanton; Lynn C Hull; Alexander Persoskie; Mark J Travers; Kristie Taylor; Kevin P Conway; Bridget K Ambrose; Nicolette Borek
Journal:  Am J Public Health       Date:  2017-07-20       Impact factor: 9.308

5.  Measuring urinary N-acetyl-S-(4-hydroxy-2-methyl-2-buten-1-yl)-L-cysteine (IPMA3) as a potential biomarker of isoprene exposure.

Authors:  K Udeni Alwis; T Liz Bailey; Dhrusti Patel; Liqun Wang; Benjamin C Blount
Journal:  Anal Chim Acta       Date:  2016-08-21       Impact factor: 6.558

6.  Multi-rule quality control for the age-related eye disease study.

Authors:  Samuel P Caudill; Rosemary L Schleicher; James L Pirkle
Journal:  Stat Med       Date:  2008-09-10       Impact factor: 2.373

Review 7.  Application of toxicological risk assessment principles to the chemical constituents of cigarette smoke.

Authors:  J Fowles; E Dybing
Journal:  Tob Control       Date:  2003-12       Impact factor: 7.552

8.  Determination of seven arsenic compounds in urine by HPLC-ICP-DRC-MS: a CDC population biomonitoring method.

Authors:  Carl P Verdon; Kathleen L Caldwell; Mark R Fresquez; Robert L Jones
Journal:  Anal Bioanal Chem       Date:  2008-12-11       Impact factor: 4.142

9.  Mainstream Smoke Levels of Volatile Organic Compounds in 50 U.S. Domestic Cigarette Brands Smoked With the ISO and Canadian Intense Protocols.

Authors:  Daniel Y Pazo; Fallon Moliere; Maureen M Sampson; Christopher M Reese; Kimberly A Agnew-Heard; Matthew J Walters; Matthew R Holman; Benjamin C Blount; Clifford H Watson; David M Chambers
Journal:  Nicotine Tob Res       Date:  2016-04-25       Impact factor: 4.244

10.  New and traditional smokeless tobacco: comparison of toxicant and carcinogen levels.

Authors:  Irina Stepanov; Joni Jensen; Dorothy Hatsukami; Stephen S Hecht
Journal:  Nicotine Tob Res       Date:  2008-12       Impact factor: 4.244
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  8 in total

1.  Tobacco-Specific Nitrosamines (NNAL, NNN, NAT, and NAB) Exposures in the US Population Assessment of Tobacco and Health (PATH) Study Wave 1 (2013-2014).

Authors:  Baoyun Xia; Benjamin C Blount; Tonya Guillot; Christina Brosius; Yao Li; Dana M Van Bemmel; Heather L Kimmel; Cindy M Chang; Nicolette Borek; Kathryn C Edwards; Charlie Lawrence; Andrew Hyland; Maciej L Goniewicz; Brittany N Pine; Yang Xia; John T Bernert; B Rey De Castro; John Lee; Justin L Brown; Stephen Arnstein; Diane Choi; Erin L Wade; Dorothy Hatsukami; Gladys Ervies; Angel Cobos; Keegan Nicodemus; Dana Freeman; Stephen S Hecht; Kevin Conway; Lanqing Wang
Journal:  Nicotine Tob Res       Date:  2021-02-16       Impact factor: 4.244

2.  Cluster analysis of urinary tobacco biomarkers among U.S. adults: Population Assessment of Tobacco and Health (PATH) biomarker study (2013-2014).

Authors:  Ban Majeed; Daniel Linder; Thomas Eissenberg; Yelena Tarasenko; Danielle Smith; David Ashley
Journal:  Prev Med       Date:  2020-07-18       Impact factor: 4.018

3.  Urinary Cyanoethyl Mercapturic Acid, a Biomarker of the Smoke Toxicant Acrylonitrile, Clearly Distinguishes Smokers From Nonsmokers.

Authors:  Xianghua Luo; Steven G Carmella; Menglan Chen; Joni A Jensen; Lynne R Wilkens; Loic Le Marchand; Dorothy K Hatsukami; Sharon E Murphy; Stephen S Hecht
Journal:  Nicotine Tob Res       Date:  2020-10-08       Impact factor: 4.244

4.  A mixed effects model for analyzing area under the curve of longitudinally measured biomarkers with missing data.

Authors:  Luoxi Shi; Dorothy K Hatsukami; Joseph S Koopmeiners; Chap T Le; Neal L Benowitz; Eric C Donny; Xianghua Luo
Journal:  Pharm Stat       Date:  2021-06-20       Impact factor: 1.894

5.  Biomarkers of Potential Harm among Adult Cigarette and Smokeless Tobacco Users in the PATH Study Wave 1 (2013-2014): A Cross-sectional Analysis.

Authors:  Joanne T Chang; Juan C Vivar; Jamie Tam; Hoda T Hammad; Carol H Christensen; Dana M van Bemmel; Babita Das; Uliana Danilenko; Cindy M Chang
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2021-05-04       Impact factor: 4.254

6.  Smokeless Tobacco Use and Prevalence of Cardiovascular Disease Among Males in the Population Assessment of Tobacco and Health (PATH) Study, Waves 1-4.

Authors:  Georges J Nahhas; K Michael Cummings; Michael J Halenar; Eva Sharma; Anthony J Alberg; Dorothy Hatuskami; Maansi Bansal-Travers; Andrew Hyland; Diann E Gaalema; Pamela B Morris; Kara Duffy; Joanne T Chang; Guy Lagaud; Juan C Vivar; Daniela Marshall; Carlos Blanco; Kristie A Taylor
Journal:  Prev Med Rep       Date:  2021-11-30

7.  Urinary Acrylonitrile Metabolite Concentrations Before and after Smoked, Vaporized, and Oral Cannabis in Frequent and Occasional Cannabis Users.

Authors:  David L Ashley; Víctor R De Jesús; Osama A Abulseoud; Marilyn A Huestis; Daniel F Milan; Benjamin C Blount
Journal:  Int J Environ Res Public Health       Date:  2020-09-04       Impact factor: 3.390

8.  Nicotine Exposure in the U.S. Population: Total Urinary Nicotine Biomarkers in NHANES 2015-2016.

Authors:  Shrila Mazumder; Winnie Shia; Patrick B Bendik; Honest Achilihu; Connie S Sosnoff; Joseph R Alexander; Zuzheng Luo; Wanzhe Zhu; Brittany N Pine; June Feng; Benjamin C Blount; Lanqing Wang
Journal:  Int J Environ Res Public Health       Date:  2022-03-19       Impact factor: 3.390
  8 in total

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