Signal Sensitivity Enhancement of High-Spatial-Resolution MR Imaging with a Concatenated Cylindrical Parametric RF-Resonator.

Phased array MRI coils can increase sensitivity of superficial tissues owing to their proximity to the detection region. Deep-lying tissues, on the other hand, do not benefit to the same degree. Here we investigate the use of a localized cylindrically symmetric quadruple frequency resonator concatenated with a double frequency resonator to increase the longitudinal field-of-view (FOV) without compromising the spatial-resolution and detection sensitivity. These concatenated array coils work on the principle of a parametric amplification to provide wireless amplification of the locally detected NMR signal prior to inductively coupling the coil to an external pick-up loop with connection to the system receiver. When both the detectors are activated together, the effective range of both overlay to create a larger FOV enabling better identification of detectable regions. Furthermore, the in-vivo test of the concatenated detector provides a worst-case 5-fold SNR gain in regions separated from the cylindrical surface larger than its own diameter. This proposed approach of concatenated detector realization can be individually activated and manipulated to enlarge the sensitivity-enhanced region without sacrificing their individual performance. Compared to double frequency detectors, quadruple frequency detectors offer more flexibility in the choice of detector dimension, enabling multi-element concatenation over an extended FOV.