Literature DB >> 31753703

Do All Roads Lead to Rome in G-Protein Activation?

Pradipta Ghosh1, Mikel Garcia-Marcos2.   

Abstract

High-resolution structural studies on G-protein-coupled receptors (GPCRs) have flourished recently, providing long-sought insights into the dynamic process of guanine nucleotide-binding protein (G-protein) activation. In parallel, analogous studies are starting to shed light on how the same G-proteins are activated by non-GPCR proteins. Can we learn about common themes and variations in G-protein activation from them?
Copyright © 2019 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  GEF; GPCR; GTPase; allosterism

Mesh：

Substances：

Year:  2019        PMID： 31753703      PMCID： PMC7147754          DOI： 10.1016/j.tibs.2019.10.010

Source DB:  PubMed          Journal:  Trends Biochem Sci        ISSN： 0968-0004            Impact factor:   13.807


  12 in total

1.  Conformational changes in the G protein Gs induced by the β2 adrenergic receptor.

Authors:  Ka Young Chung; Søren G F Rasmussen; Tong Liu; Sheng Li; Brian T DeVree; Pil Seok Chae; Diane Calinski; Brian K Kobilka; Virgil L Woods; Roger K Sunahara
Journal:  Nature       Date:  2011-09-28       Impact factor: 49.962

2.  G-protein diseases furnish a model for the turn-on switch.

Authors:  T Iiri; Z Farfel; H R Bourne
Journal:  Nature       Date:  1998-07-02       Impact factor: 49.962

3.  Structural basis for GPCR-independent activation of heterotrimeric Gi proteins.

Authors:  Nicholas A Kalogriopoulos; Steven D Rees; Tony Ngo; Noah J Kopcho; Andrey V Ilatovskiy; Nina Sun; Elizabeth A Komives; Geoffrey Chang; Pradipta Ghosh; Irina Kufareva
Journal:  Proc Natl Acad Sci U S A       Date:  2019-07-30       Impact factor: 11.205

Review 4.  Mechanistic insights into GPCR-G protein interactions.

Authors:  Jacob P Mahoney; Roger K Sunahara
Journal:  Curr Opin Struct Biol       Date:  2016-11-18       Impact factor: 6.809

5.  Structures of the Rhodopsin-Transducin Complex: Insights into G-Protein Activation.

Authors:  Yang Gao; Hongli Hu; Sekar Ramachandran; Jon W Erickson; Richard A Cerione; Georgios Skiniotis
Journal:  Mol Cell       Date:  2019-07-09       Impact factor: 17.970

6.  SIGNAL TRANSDUCTION. Structural basis for nucleotide exchange in heterotrimeric G proteins.

Authors:  Ron O Dror; Thomas J Mildorf; Daniel Hilger; Aashish Manglik; David W Borhani; Daniel H Arlow; Ansgar Philippsen; Nicolas Villanueva; Zhongyu Yang; Michael T Lerch; Wayne L Hubbell; Brian K Kobilka; Roger K Sunahara; David E Shaw
Journal:  Science       Date:  2015-06-19       Impact factor: 47.728

7.  Universal allosteric mechanism for Gα activation by GPCRs.

Authors:  Charles N J Ravarani; Dawei Sun; Tilman Flock; A J Venkatakrishnan; Melis Kayikci; Christopher G Tate; Dmitry B Veprintsev; M Madan Babu
Journal:  Nature       Date:  2015-07-06       Impact factor: 49.962

8.  Ric-8A, a G protein chaperone with nucleotide exchange activity induces long-range secondary structure changes in Gα.

Authors:  Ravi Kant; Baisen Zeng; Celestine J Thomas; Brian Bothner; Stephen R Sprang
Journal:  Elife       Date:  2016-12-23       Impact factor: 8.140

Review 9.  Heterotrimeric G proteins as emerging targets for network based therapy in cancer: End of a long futile campaign striking heads of a Hydra.

Authors:  Pradipta Ghosh
Journal:  Aging (Albany NY)       Date:  2015-07       Impact factor: 5.682

10.  Molecular mechanism of Gαi activation by non-GPCR proteins with a Gα-Binding and Activating motif.

Authors:  Alain Ibáñez de Opakua; Kshitij Parag-Sharma; Vincent DiGiacomo; Nekane Merino; Anthony Leyme; Arthur Marivin; Maider Villate; Lien T Nguyen; Miguel Angel de la Cruz-Morcillo; Juan B Blanco-Canosa; Sekar Ramachandran; George S Baillie; Richard A Cerione; Francisco J Blanco; Mikel Garcia-Marcos
Journal:  Nat Commun       Date:  2017-05-18       Impact factor: 14.919
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  3 in total

Review 1.  Regulating cellular cyclic adenosine monophosphate: "Sources," "sinks," and now, "tunable valves".

Authors:  Michael Getz; Padmini Rangamani; Pradipta Ghosh
Journal:  Wiley Interdiscip Rev Syst Biol Med       Date:  2020-04-23

Review 2.  The Conformational Dynamics of Heterotrimeric G Proteins During GPCR-Mediated Activation.

Authors:  Donghoon Ahn; Ka Young Chung
Journal:  Subcell Biochem       Date:  2022

3.  Building unconventional G protein-coupled receptors, one block at a time.

Authors:  Pradipta Ghosh; Madhubanti Mullick
Journal:  Trends Pharmacol Sci       Date:  2021-05-10       Impact factor: 14.819
  3 in total

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