Literature DB >> 9665125

G-protein diseases furnish a model for the turn-on switch.

T Iiri1, Z Farfel, H R Bourne.   

Abstract

How does a trimeric G protein on the inside of a cell membrane respond to activation by a transmembrane receptor? G-protein mutations in patients with hypertension and inherited endocrine disorders enhance or block signals from stimulated receptors. In combination with three-dimensional crystal structures and results from biochemical experiments, the phenotypes produced by these mutations suggest a model for the molecular activation mechanism that relays hormonal and sensory signals transmitted by many transmembrane receptors.

Entities:  

Mesh：

Substances：

Year:  1998        PMID： 9665125     DOI： 10.1038/27831

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  45 in total

1.  Conversion of agonist site to metal-ion chelator site in the beta(2)-adrenergic receptor.

Authors:  C E Elling; K Thirstrup; B Holst; T W Schwartz
Journal:  Proc Natl Acad Sci U S A       Date:  1999-10-26       Impact factor: 11.205

2.  Signal transfer from rhodopsin to the G-protein: evidence for a two-site sequential fit mechanism.

Authors:  O G Kisselev; C K Meyer; M Heck; O P Ernst; K P Hofmann
Journal:  Proc Natl Acad Sci U S A       Date:  1999-04-27       Impact factor: 11.205

Review 3.  Nucleoside diphosphate kinases in mammalian signal transduction systems: recent development and perspective.

Authors:  Narimichi Kimura; Nobuko Shimada; Yasushi Ishijima; Mitsugu Fukuda; Yohko Takagi; Naoshi Ishikawa
Journal:  J Bioenerg Biomembr       Date:  2003-02       Impact factor: 2.945

Review 4.  Recent advances in drug action and therapeutics: relevance of novel concepts in G-protein-coupled receptor and signal transduction pharmacology.

Authors:  C B Brink; B H Harvey; J Bodenstein; D P Venter; D W Oliver
Journal:  Br J Clin Pharmacol       Date:  2004-04       Impact factor: 4.335

Review 5.  Probing heterotrimeric G protein activation: applications to biased ligands.

Authors:  Colette Denis; Aude Saulière; Segolene Galandrin; Jean-Michel Sénard; Céline Galés
Journal:  Curr Pharm Des       Date:  2012       Impact factor: 3.116

Review 6.  Heterotrimeric G protein signaling via GIV/Girdin: Breaking the rules of engagement, space, and time.

Authors:  Nicolas Aznar; Nicholas Kalogriopoulos; Krishna K Midde; Pradipta Ghosh
Journal:  Bioessays       Date:  2016-02-16       Impact factor: 4.345

7.  Structure of Galpha(i1) bound to a GDP-selective peptide provides insight into guanine nucleotide exchange.

Authors:  Christopher A Johnston; Francis S Willard; Mark R Jezyk; Zoey Fredericks; Erik T Bodor; Miller B Jones; Rainer Blaesius; Val J Watts; T Kendall Harden; John Sondek; J Kevin Ramer; David P Siderovski
Journal:  Structure       Date:  2005-07       Impact factor: 5.006

Review 8.  Computational methods in drug design: modeling G protein-coupled receptor monomers, dimers, and oligomers.

Authors:  Patricia H Reggio
Journal:  AAPS J       Date:  2006-05-12       Impact factor: 4.009

Review 9.  Implications of non-canonical G-protein signaling for the immune system.

Authors:  Cédric Boularan; John H Kehrl
Journal:  Cell Signal       Date:  2014-02-28       Impact factor: 4.315

10.  Inactivation of G-protein-coupled receptor 48 (Gpr48/Lgr4) impairs definitive erythropoiesis at midgestation through down-regulation of the ATF4 signaling pathway.

Authors:  Huiping Song; Jian Luo; Weijia Luo; Jinsheng Weng; Zhiqiang Wang; Baoxing Li; Dali Li; Mingyao Liu
Journal:  J Biol Chem       Date:  2008-10-27       Impact factor: 5.157
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.