Literature DB >> 33985816

Building unconventional G protein-coupled receptors, one block at a time.

Pradipta Ghosh1, Madhubanti Mullick2.   

Abstract

The structure, function, and dynamics of canonical activation of heterotrimeric G proteins by the seven-transmembrane G protein-coupled receptors (GPCRs) have been illustrated in detail. However, emerging studies during the past decade have started to shed light on how the same G proteins may also be accessed and modulated by a diverse family of receptors that are not conventional GPCRs. Can we learn about common themes and variations in how cells assemble these atypical GPCRs?
Copyright © 2021 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Frizzled; GPCRs; Toll-like receptors; growth factors; guanine-nucleotide exchange modulators (GEMs); integrins

Mesh：

Substances：

Year:  2021        PMID： 33985816      PMCID： PMC8779748          DOI： 10.1016/j.tips.2021.04.005

Source DB:  PubMed          Journal:  Trends Pharmacol Sci        ISSN： 0165-6147            Impact factor:   14.819


  19 in total

1.  GIV is a nonreceptor GEF for G alpha i with a unique motif that regulates Akt signaling.

Authors:  Mikel Garcia-Marcos; Pradipta Ghosh; Marilyn G Farquhar
Journal:  Proc Natl Acad Sci U S A       Date:  2009-02-11       Impact factor: 11.205

2.  Structural basis for GPCR-independent activation of heterotrimeric Gi proteins.

Authors:  Nicholas A Kalogriopoulos; Steven D Rees; Tony Ngo; Noah J Kopcho; Andrey V Ilatovskiy; Nina Sun; Elizabeth A Komives; Geoffrey Chang; Pradipta Ghosh; Irina Kufareva
Journal:  Proc Natl Acad Sci U S A       Date:  2019-07-30       Impact factor: 11.205

3.  DAPLE protein inhibits nucleotide exchange on Gαs and Gαq via the same motif that activates Gαi.

Authors:  Arthur Marivin; Marcin Maziarz; Jingyi Zhao; Vincent DiGiacomo; Isabel Olmos Calvo; Emily A Mann; Jason Ear; Juan B Blanco-Canosa; Elliott M Ross; Pradipta Ghosh; Mikel Garcia-Marcos
Journal:  J Biol Chem       Date:  2020-01-16       Impact factor: 5.157

4.  Therapeutic effects of cell-permeant peptides that activate G proteins downstream of growth factors.

Authors:  Gary S Ma; Nicolas Aznar; Nicholas Kalogriopoulos; Krishna K Midde; Inmaculada Lopez-Sanchez; Emi Sato; Ying Dunkel; Richard L Gallo; Pradipta Ghosh
Journal:  Proc Natl Acad Sci U S A       Date:  2015-04-29       Impact factor: 11.205

5.  Specific inhibition of GPCR-independent G protein signaling by a rationally engineered protein.

Authors:  Anthony Leyme; Arthur Marivin; Marcin Maziarz; Vincent DiGiacomo; Maria P Papakonstantinou; Prachi P Patel; Juan B Blanco-Canosa; Isha A Walawalkar; Gonzalo Rodriguez-Davila; Isabel Dominguez; Mikel Garcia-Marcos
Journal:  Proc Natl Acad Sci U S A       Date:  2017-11-13       Impact factor: 11.205

6.  TLR4 signaling and macrophage inflammatory responses are dampened by GIV/Girdin.

Authors:  Lee Swanson; Gajanan D Katkar; Julian Tam; Rama F Pranadinata; Yogitha Chareddy; Jane Coates; Mahitha Shree Anandachar; Vanessa Castillo; Joshua Olson; Victor Nizet; Irina Kufareva; Soumita Das; Pradipta Ghosh
Journal:  Proc Natl Acad Sci U S A       Date:  2020-10-14       Impact factor: 11.205

Review 7.  Do All Roads Lead to Rome in G-Protein Activation?

Authors:  Pradipta Ghosh; Mikel Garcia-Marcos
Journal:  Trends Biochem Sci       Date:  2019-11-18       Impact factor: 13.807

8.  The Gαi-GIV binding interface is a druggable protein-protein interaction.

Authors:  Vincent DiGiacomo; Alain Ibáñez de Opakua; Maria P Papakonstantinou; Lien T Nguyen; Nekane Merino; Juan B Blanco-Canosa; Francisco J Blanco; Mikel Garcia-Marcos
Journal:  Sci Rep       Date:  2017-08-17       Impact factor: 4.379

9.  Molecular mechanism of Gαi activation by non-GPCR proteins with a Gα-Binding and Activating motif.

Authors:  Alain Ibáñez de Opakua; Kshitij Parag-Sharma; Vincent DiGiacomo; Nekane Merino; Anthony Leyme; Arthur Marivin; Maider Villate; Lien T Nguyen; Miguel Angel de la Cruz-Morcillo; Juan B Blanco-Canosa; Sekar Ramachandran; George S Baillie; Richard A Cerione; Francisco J Blanco; Mikel Garcia-Marcos
Journal:  Nat Commun       Date:  2017-05-18       Impact factor: 14.919

10.  Optogenetic activation of heterotrimeric G-proteins by LOV2GIVe, a rationally engineered modular protein.

Authors:  Mikel Garcia-Marcos; Kshitij Parag-Sharma; Arthur Marivin; Marcin Maziarz; Alex Luebbers; Lien T Nguyen
Journal:  Elife       Date:  2020-09-16       Impact factor: 8.140
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