Literature DB >> 31617035

Perspective: the essential role of NMR in the discovery and characterization of intrinsically disordered proteins.

H Jane Dyson1, Peter E Wright2.   

Abstract

The 2019 ISMAR Prize recognized NMR studies of disordered proteins. Here we provide a highly personal perspective on the discovery of intrinsically disordered proteins and the development and application of NMR methods to characterize their conformational ensembles, dynamics, and interactions.

Entities:  

Keywords:  Immunogenic peptides; Intrinsically disordered proteins; Protein folding; Relaxation dispersion

Mesh：

Substances：

Year:  2019        PMID： 31617035      PMCID： PMC7043288          DOI： 10.1007/s10858-019-00280-2

Source DB:  PubMed          Journal:  J Biomol NMR        ISSN： 0925-2738            Impact factor:   2.835


  76 in total

1.  Mechanism of coupled folding and binding of an intrinsically disordered protein.

Authors:  Kenji Sugase; H Jane Dyson; Peter E Wright
Journal:  Nature       Date:  2007-05-23       Impact factor: 49.962

Review 2.  Exploring free-energy landscapes of intrinsically disordered proteins at atomic resolution using NMR spectroscopy.

Authors:  Malene Ringkjøbing Jensen; Markus Zweckstetter; Jie-rong Huang; Martin Blackledge
Journal:  Chem Rev       Date:  2014-04-11       Impact factor: 60.622

3.  Generation of protein-reactive antibodies by short peptides is an event of high frequency: implications for the structural basis of immune recognition.

Authors:  H L Niman; R A Houghten; L E Walker; R A Reisfeld; I A Wilson; J M Hogle; R A Lerner
Journal:  Proc Natl Acad Sci U S A       Date:  1983-08       Impact factor: 11.205

4.  The character of the stored molecules in chromaffin granules of the adrenal medulla: a nuclear magnetic resonance study.

Authors:  A J Daniels; R J Williams; P E Wright
Journal:  Neuroscience       Date:  1978       Impact factor: 3.590

5.  Extreme disorder in an ultrahigh-affinity protein complex.

Authors:  Alessandro Borgia; Madeleine B Borgia; Katrine Bugge; Vera M Kissling; Pétur O Heidarsson; Catarina B Fernandes; Andrea Sottini; Andrea Soranno; Karin J Buholzer; Daniel Nettels; Birthe B Kragelund; Robert B Best; Benjamin Schuler
Journal:  Nature       Date:  2018-02-21       Impact factor: 49.962

6.  Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation.

Authors:  P Jaakkola; D R Mole; Y M Tian; M I Wilson; J Gielbert; S J Gaskell; A von Kriegsheim; H F Hebestreit; M Mukherji; C J Schofield; P H Maxwell; C W Pugh; P J Ratcliffe
Journal:  Science       Date:  2001-04-05       Impact factor: 47.728

7.  Structural basis for Hif-1 alpha /CBP recognition in the cellular hypoxic response.

Authors:  Sonja A Dames; Maria Martinez-Yamout; Roberto N De Guzman; H Jane Dyson; Peter E Wright
Journal:  Proc Natl Acad Sci U S A       Date:  2002-04-16       Impact factor: 11.205

8.  NMR determination of residual structure in a urea-denatured protein, the 434-repressor.

Authors:  D Neri; M Billeter; G Wider; K Wüthrich
Journal:  Science       Date:  1992-09-11       Impact factor: 47.728

9.  Folding of immunogenic peptide fragments of proteins in water solution. II. The nascent helix.

Authors:  H J Dyson; M Rance; R A Houghten; P E Wright; R A Lerner
Journal:  J Mol Biol       Date:  1988-05-05       Impact factor: 5.469

Review 10.  What's in a name? Why these proteins are intrinsically disordered: Why these proteins are intrinsically disordered.

Authors:  A Keith Dunker; M Madan Babu; Elisar Barbar; Martin Blackledge; Sarah E Bondos; Zsuzsanna Dosztányi; H Jane Dyson; Julie Forman-Kay; Monika Fuxreiter; Jörg Gsponer; Kyou-Hoon Han; David T Jones; Sonia Longhi; Steven J Metallo; Ken Nishikawa; Ruth Nussinov; Zoran Obradovic; Rohit V Pappu; Burkhard Rost; Philipp Selenko; Vinod Subramaniam; Joel L Sussman; Peter Tompa; Vladimir N Uversky
Journal:  Intrinsically Disord Proteins       Date:  2013-04-01
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  14 in total

1.  The Intrinsically Disordered Region of ExbD Is Required for Signal Transduction.

Authors:  Dale R Kopp; Kathleen Postle
Journal:  J Bacteriol       Date:  2020-03-11       Impact factor: 3.490

Review 2.  NMR methods for exploring 'dark' states in ligand binding and protein-protein interactions.

Authors:  Vitali Tugarinov; Alberto Ceccon; G Marius Clore
Journal:  Prog Nucl Magn Reson Spectrosc       Date:  2021-11-02       Impact factor: 9.795

Review 3.  Lighting up Nobel Prize-winning studies with protein intrinsic disorder.

Authors:  Lolita Piersimoni; Marina Abd El Malek; Twinkle Bhatia; Julian Bender; Christin Brankatschk; Jaime Calvo Sánchez; Guy W Dayhoff; Alessio Di Ianni; Jhonny Oscar Figueroa Parra; Dailen Garcia-Martinez; Julia Hesselbarth; Janett Köppen; Luca M Lauth; Laurin Lippik; Lisa Machner; Shubhra Sachan; Lisa Schmidt; Robin Selle; Ioannis Skalidis; Oleksandr Sorokin; Daniele Ubbiali; Bruno Voigt; Alice Wedler; Alan An Jung Wei; Peter Zorn; Alan Keith Dunker; Marcel Köhn; Andrea Sinz; Vladimir N Uversky
Journal:  Cell Mol Life Sci       Date:  2022-07-26       Impact factor: 9.207

4.  NMR spectroscopy, excited states and relevance to problems in cell biology - transient pre-nucleation tetramerization of huntingtin and insights into Huntington's disease.

Authors:  G Marius Clore
Journal:  J Cell Sci       Date:  2022-06-15       Impact factor: 5.235

5.  Measuring thermodynamic preferences to form non-native conformations in nucleic acids using ultraviolet melting.

Authors:  Atul Rangadurai; Honglue Shi; Yu Xu; Bei Liu; Hala Abou Assi; John D Boom; Huiqing Zhou; Isaac J Kimsey; Hashim M Al-Hashimi
Journal:  Proc Natl Acad Sci U S A       Date:  2022-06-07       Impact factor: 12.779

Review 6.  Unraveling protein's structural dynamics: from configurational dynamics to ensemble switching guides functional mesoscale assemblies.

Authors:  Exequiel Medina; Danielle R Latham; Hugo Sanabria
Journal:  Curr Opin Struct Biol       Date:  2020-11-24       Impact factor: 6.809

Review 7.  Beyond history and "on a roll": The list of the most well-studied human protein structures and overall trends in the protein data bank.

Authors:  Zhen-Lu Li; Matthias Buck
Journal:  Protein Sci       Date:  2021-03-04       Impact factor: 6.725

Review 8.  NMR illuminates intrinsic disorder.

Authors:  H Jane Dyson; Peter E Wright
Journal:  Curr Opin Struct Biol       Date:  2021-05-02       Impact factor: 7.786

Review 9.  Fatal Attraction: The Case of Toxic Soluble Dimers of Truncated PQBP-1 Mutants in X-Linked Intellectual Disability.

Authors:  Yu Wai Chen; Shah Kamranur Rahman
Journal:  Int J Mol Sci       Date:  2021-02-24       Impact factor: 5.923

10.  Musashi-1: An Example of How Polyalanine Tracts Contribute to Self-Association in the Intrinsically Disordered Regions of RNA-Binding Proteins.

Authors:  Tsai-Chen Chen; Jie-Rong Huang
Journal:  Int J Mol Sci       Date:  2020-03-26       Impact factor: 5.923
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