Stephen H Kennedy1,2, Cesar G Victora3, Ricardo Uauy4,5, Zulfiqar A Bhutta6,7, José Villar1,2, Rachel Craik1,2, Stephen Ash1,8, Fernando C Barros9, Hellen C Barsosio10, James A Berkley10,11, Maria Carvalho12, Michelle Fernandes1,13, Leila Cheikh Ismail1,14, Ann Lambert1,2, Cecilia M Lindgren15, Rose McGready16, Shama Munim17, Christoffer Nellåker1,15, Julia A Noble18, Shane A Norris19, Francois Nosten16, Eric O Ohuma1,20,6, Aris T Papageorghiou1,2, Alan Stein21, William Stones12,22, Chrystelle O O Tshivuila-Matala1,19,23, Eleonora Staines Urias1,2, Manu Vatish1, Katharina Wulff24, Ghulam Zainab17, Krina T Zondervan1,25. 1. Nuffield Department of Women's & Reproductive Health, University of Oxford, Oxford, UK. 2. Oxford Maternal & Perinatal Health Institute, Green Templeton College, Oxford, UK. 3. Programa de Pós-Graduação em Epidemiologia, Universidade Federal de Pelotas, Pelotas, RS, Brazil. 4. Division of Paediatrics, Pontifical Universidad Catolica de Chile, Santiago, Chile. 5. Department of Nutrition and Public Health Interventions Research, London School of Hygiene and Tropical Medicine, London, UK. 6. Center for Global Child Health, Hospital for Sick Children, Toronto, Canada. 7. Department of Paediatrics and Child Health, Aga Khan University, Karachi, Pakistan. 8. Oxford Ludwig Institute, University of Oxford, Oxford, UK. 9. Programa de Pós-Graduação em Saúde e Comportamento, Universidade Federal de Pelotas, Pelotas, RS, Brazil. 10. KEMRI-Coast Centre for Geographical Medicine and Research, University of Oxford, Kilifi, Kenya. 11. Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK. 12. Faculty of Health Sciences, Aga Khan University, Nairobi, Kenya. 13. Faculty of Medicine, Department of Paediatrics, University of Southampton, Southampton, UK. 14. Department of Clinical Nutrition and Dietetics, College of Health Sciences, University of Sharjah, Sharjah, United Arab Emirates. 15. Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK. 16. Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand. 17. Department of Obstetrics and Gynaecology, Division of Women and Child Health, Aga Khan University, Karachi, Pakistan. 18. Department of Engineering Science, University of Oxford, Oxford, UK. 19. SAMRC Developmental Pathways For Health Research Unit, Department of Paediatrics & Child Health, University of the Witwatersrand, Johannesburg, South Africa. 20. Centre for Statistics in Medicine, Botnar Research Centre, University of Oxford, Oxford, UK. 21. Department of Psychiatry, University of Oxford, Oxford, UK. 22. Departments of Public Health and Obstetrics & Gynaecology, Malawi College of Medicine, Blantyre, Malawi. 23. Health, Nutrition & Population Global Practice, World Bank Group, Washington, DC, USA. 24. Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK. 25. Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
Abstract
Background: INTERBIO-21 st is Phase II of the INTERGROWTH-21 st Project, the population-based, research initiative involving nearly 70,000 mothers and babies worldwide coordinated by Oxford University and performed by a multidisciplinary network of more than 400 healthcare professionals and scientists from 35 institutions in 21 countries worldwide. Phase I, conducted 2008-2015, consisted of nine complementary studies designed to describe optimal human growth and neurodevelopment, based conceptually on the WHO prescriptive approach. The studies generated a set of international standards for monitoring growth and neurodevelopment, which complement the existing WHO Child Growth Standards. Phase II aims to improve the functional classification of the highly heterogenous preterm birth and fetal growth restriction syndromes through a better understanding of how environmental exposures, clinical conditions and nutrition influence patterns of human growth from conception to childhood, as well as specific neurodevelopmental domains and associated behaviors at 2 years of age. Methods: In the INTERBIO-21 st Newborn Case-Control Study, a major component of Phase II, our objective is to investigate the mechanisms potentially responsible for preterm birth and small for gestational age and their interactions, using deep phenotyping of clinical, growth and epidemiological data and associated nutritional, biochemical, omic and histological profiles. Here we describe the study sites, population characteristics, study design, methodology and standardization procedures for the collection of longitudinal clinical data and biological samples (maternal blood, umbilical cord blood, placental tissue, maternal feces and infant buccal swabs) for the study that was conducted between 2012 and 2018 in Brazil, Kenya, Pakistan, South Africa, Thailand and the UK. Discussion: Our study provides a unique resource for the planned analyses given the range of potentially disadvantageous exposures (including poor nutrition, pregnancy complications and infections) in geographically diverse populations worldwide. The study should enhance current medical knowledge and provide new insights into environmental influences on human growth and neurodevelopment.
Background: INTERBIO-21 st is Phase II of the INTERGROWTH-21 st Project, the population-based, research initiative involving nearly 70,000 mothers and babies worldwide coordinated by Oxford University and performed by a multidisciplinary network of more than 400 healthcare professionals and scientists from 35 institutions in 21 countries worldwide. Phase I, conducted 2008-2015, consisted of nine complementary studies designed to describe optimal human growth and neurodevelopment, based conceptually on the WHO prescriptive approach. The studies generated a set of international standards for monitoring growth and neurodevelopment, which complement the existing WHO Child Growth Standards. Phase II aims to improve the functional classification of the highly heterogenous preterm birth and fetal growth restriction syndromes through a better understanding of how environmental exposures, clinical conditions and nutrition influence patterns of human growth from conception to childhood, as well as specific neurodevelopmental domains and associated behaviors at 2 years of age. Methods: In the INTERBIO-21 st Newborn Case-Control Study, a major component of Phase II, our objective is to investigate the mechanisms potentially responsible for preterm birth and small for gestational age and their interactions, using deep phenotyping of clinical, growth and epidemiological data and associated nutritional, biochemical, omic and histological profiles. Here we describe the study sites, population characteristics, study design, methodology and standardization procedures for the collection of longitudinal clinical data and biological samples (maternal blood, umbilical cord blood, placental tissue, maternal feces and infant buccal swabs) for the study that was conducted between 2012 and 2018 in Brazil, Kenya, Pakistan, South Africa, Thailand and the UK. Discussion: Our study provides a unique resource for the planned analyses given the range of potentially disadvantageous exposures (including poor nutrition, pregnancy complications and infections) in geographically diverse populations worldwide. The study should enhance current medical knowledge and provide new insights into environmental influences on human growth and neurodevelopment.
Authors: I Sarris; C Ioannou; M Dighe; A Mitidieri; M Oberto; W Qingqing; J Shah; S Sohoni; W Al Zidjali; L Hoch; D G Altman; A T Papageorghiou Journal: Ultrasound Obstet Gynecol Date: 2011-12 Impact factor: 7.299
Authors: I Sarris; C Ioannou; E O Ohuma; D G Altman; L Hoch; C Cosgrove; S Fathima; L J Salomon; A T Papageorghiou Journal: BJOG Date: 2013-07-11 Impact factor: 6.531
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Authors: Elizabeth Murray; Michelle Fernandes; Charles R J Newton; Amina Abubakar; Stephen H Kennedy; Jose Villar; Alan Stein Journal: PLoS One Date: 2018-02-28 Impact factor: 3.240
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Authors: Zulfiqar A Bhutta; Aris T Papageorghiou; Stephen H Kennedy; José Villar; Robert B Gunier; Chrystelle O O Tshivuila-Matala; Stephen A Rauch; Francois Nosten; Roseline Ochieng; María C Restrepo-Méndez; Rose McGready; Fernando C Barros; Michelle Fernandes; Verena I Carrara; Cesar G Victora; Shama Munim; Rachel Craik; Hellen C Barsosio; Maria Carvalho; James A Berkley; Leila Cheikh Ismail; Shane A Norris; Eric O Ohuma; Alan Stein; Ann Lambert; Adele Winsey; Ricardo Uauy; Brenda Eskenazi Journal: Nat Med Date: 2021-03-18 Impact factor: 87.241
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Authors: Hellen C Barsosio; John N Gitonga; Henry K Karanja; Doris K Nyamwaya; Donwilliams O Omuoyo; Everlyn Kamau; Mainga M Hamaluba; Joyce U Nyiro; Barnes S Kitsao; Amek Nyaguara; Stella Mwakio; Charles R Newton; Rosemary Sang; Daniel Wright; Eduard J Sanders; Anna C Seale; Charles N Agoti; James A Berkley; Philip Bejon; George M Warimwe Journal: Wellcome Open Res Date: 2019-11-15
Authors: Jeffrey N Bone; Kelly Pickerill; Mai-Lei Woo Kinshella; Marianne Vidler; Rachel Craik; Lucilla Poston; William Stones; Esperanca Sevene; Marleen Temmerman; Angela Koech Etyang; Anna Roca; Donna Russell; Rachel M Tribe; Peter von Dadelszen; Laura A Magee Journal: BMJ Glob Health Date: 2020-11