Literature DB >> 30879799

The impact of chlorhexidine gluconate on the skin microbiota of children and adults: A pilot study.

Ashley E Kates1, Michele L Zimbric2, Kaitlin Mitchell3, Joseph Skarlupka2, Nasia Safdar2.   

Abstract

We examined the effect of chlorhexidine gluconate (CHG) bathing on the skin microbiota of adult and pediatric patients. We observed no differences in pediatric patients; however, multiple genera of bacteria were observed to be significantly less abundant in the adults bathing with CHG. Further research is needed to determine the long-term impact of CHG use on the skin microbiota.
Copyright © 2019 Association for Professionals in Infection Control and Epidemiology, Inc. All rights reserved.

Entities:  

Keywords:  16S rRNA sequencing; Antiseptics; Microbiome; Pediatrics

Mesh：

Substances：

Year:  2019        PMID： 30879799      PMCID： PMC6736594          DOI： 10.1016/j.ajic.2019.01.024

Source DB:  PubMed          Journal:  Am J Infect Control        ISSN： 0196-6553            Impact factor:   2.918


  10 in total

1.  UPARSE: highly accurate OTU sequences from microbial amplicon reads.

Authors:  Robert C Edgar
Journal:  Nat Methods       Date:  2013-08-18       Impact factor: 28.547

2.  The effectiveness of routine daily chlorhexidine gluconate bathing in reducing Klebsiella pneumoniae carbapenemase-producing Enterobacteriaceae skin burden among long-term acute care hospital patients.

Authors:  Michael Y Lin; Karen Lolans; Donald W Blom; Rosie D Lyles; Shayna Weiner; Kavya B Poluru; Nicholas Moore; David W Hines; Robert A Weinstein; Mary K Hayden
Journal:  Infect Control Hosp Epidemiol       Date:  2014-04       Impact factor: 3.254

3.  Reduction in hospital-associated methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus with daily chlorhexidine gluconate bathing for medical inpatients.

Authors:  Christopher F Lowe; Elisa Lloyd-Smith; Baljinder Sidhu; Gordon Ritchie; Azra Sharma; Willson Jang; Anna Wong; Jennifer Bilawka; Danielle Richards; Thomas Kind; David Puddicombe; Sylvie Champagne; Victor Leung; Marc G Romney
Journal:  Am J Infect Control       Date:  2016-12-08       Impact factor: 2.918

4.  Insights into bacterial colonization of intensive care patients' skin: the effect of chlorhexidine daily bathing.

Authors:  N Cassir; L Papazian; P-E Fournier; D Raoult; B La Scola
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2015-01-22       Impact factor: 3.267

Review 5.  Impact of non-rinse skin cleansing with chlorhexidine gluconate on prevention of healthcare-associated infections and colonization with multi-resistant organisms: a systematic review.

Authors:  S Karki; A C Cheng
Journal:  J Hosp Infect       Date:  2012-08-11       Impact factor: 3.926

6.  Relationship between chlorhexidine gluconate skin concentration and microbial density on the skin of critically ill patients bathed daily with chlorhexidine gluconate.

Authors:  Kyle J Popovich; Rosie Lyles; Robert Hayes; Bala Hota; William Trick; Robert A Weinstein; Mary K Hayden
Journal:  Infect Control Hosp Epidemiol       Date:  2012-07-23       Impact factor: 3.254

Review 7.  Decolonization in Prevention of Health Care-Associated Infections.

Authors:  Edward J Septimus; Marin L Schweizer
Journal:  Clin Microbiol Rev       Date:  2016-04       Impact factor: 26.132

8.  Multistate point-prevalence survey of health care-associated infections.

Authors:  Shelley S Magill; Jonathan R Edwards; Wendy Bamberg; Zintars G Beldavs; Ghinwa Dumyati; Marion A Kainer; Ruth Lynfield; Meghan Maloney; Laura McAllister-Hollod; Joelle Nadle; Susan M Ray; Deborah L Thompson; Lucy E Wilson; Scott K Fridkin
Journal:  N Engl J Med       Date:  2014-03-27       Impact factor: 91.245

Review 9.  Prevention of hospital-acquired bloodstream infections through chlorhexidine gluconate-impregnated washcloth bathing in intensive care units: a systematic review and meta-analysis of randomised crossover trials.

Authors:  Elsa Afonso; Koen Blot; Stijn Blot
Journal:  Euro Surveill       Date:  2016-11-17

10.  Wisconsin microbiome study, a cross-sectional investigation of dietary fibre, microbiome composition and antibiotic-resistant organisms: rationale and methods.

Authors:  Shoshannah Eggers; Kristen Mc Malecki; Paul Peppard; Julie Mares; Daniel Shirley; Sanjay K Shukla; Keith Poulsen; Ronald Gangnon; Megan Duster; Ashley Kates; Garret Suen; Ajay K Sethi; Nasia Safdar
Journal:  BMJ Open       Date:  2018-03-27       Impact factor: 2.692
  10 in total
  6 in total

1.  Chlorhexidine Gluconate Bathing Reduces the Incidence of Bloodstream Infections in Adults Undergoing Inpatient Hematopoietic Cell Transplantation.

Authors:  Vinay K Giri; Kristin G Kegerreis; Yi Ren; Lauren M Bohannon; Erica Lobaugh-Jin; Julia A Messina; Anita Matthews; Yvonne M Mowery; Elizabeth Sito; Martha Lassiter; Jennifer L Saullo; Sin-Ho Jung; Li Ma; Morris Greenberg; Tessa M Andermann; Marcel R M van den Brink; Jonathan U Peled; Antonio L C Gomes; Taewoong Choi; Cristina J Gasparetto; Mitchell E Horwitz; Gwynn D Long; Richard D Lopez; David A Rizzieri; Stefanie Sarantopoulos; Nelson J Chao; Deborah H Allen; Anthony D Sung
Journal:  Transplant Cell Ther       Date:  2021-01-07

2.  Cutaneous Microbiome Profiles Following Chlorhexidine Treatment in a 72-Hour Daily Follow-Up Paired Design: a Pilot Study.

Authors:  Jean-Luc C Mougeot; Micaela F Beckman; Farah Bahrani Mougeot; James M Horton
Journal:  Microbiol Spectr       Date:  2022-06-21

3.  Transitory Shifts in Skin Microbiota Composition and Reductions in Bacterial Load and Psoriasin following Ethanol Perturbation.

Authors:  Charis R Saville; Aline Metris; Gavin J Humphreys; Catherine O'Neill; Paul Barrett; Judith Fernandez-Piquer; Andrew J McBain
Journal:  mSphere       Date:  2022-06-21       Impact factor: 5.029

4.  Skin microbiota analysis in patients with anorexia nervosa and healthy-weight controls reveals microbial indicators of healthy weight and associations with the antimicrobial peptide psoriasin.

Authors:  Britt M Hermes; Franziska Rademacher; Cecilia Chung; Gisa Tiegs; Marie-Christin Bendix; Martina de Zwaan; Jürgen Harder; John F Baines
Journal:  Sci Rep       Date:  2022-09-15       Impact factor: 4.996

Review 5.  Assessing the Potential for Unintended Microbial Consequences of Routine Chlorhexidine Bathing for Prevention of Healthcare-associated Infections.

Authors:  Ahmed Babiker; Joseph D Lutgring; Scott Fridkin; Mary K Hayden
Journal:  Clin Infect Dis       Date:  2021-03-01       Impact factor: 9.079

6.  Murine model of colonization with fungal pathogen Candida auris to explore skin tropism, host risk factors and therapeutic strategies.

Authors:  Xin Huang; Charlotte Hurabielle; Rebecca A Drummond; Nicolas Bouladoux; Jigar V Desai; Choon K Sim; Yasmine Belkaid; Michail S Lionakis; Julia A Segre
Journal:  Cell Host Microbe       Date:  2020-12-31       Impact factor: 21.023
  6 in total

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