Literature DB >> 32766819

Assessing the Potential for Unintended Microbial Consequences of Routine Chlorhexidine Bathing for Prevention of Healthcare-associated Infections.

Ahmed Babiker1,2, Joseph D Lutgring3, Scott Fridkin1, Mary K Hayden4,5.   

Abstract

Chlorhexidine gluconate (CHG) is an antiseptic that is widely used in healthcare due to its excellent safety profile and wide spectrum of activity. Daily bathing with CHG has proven to be effective in the prevention of healthcare-associated infections and multidrug-resistant pathogen decolonization. Despite the proven benefits of CHG use, there remain concerns and unanswered questions about the potential for unintended microbial consequences of routine CHG bathing. This review aims to explore some of these questions.
© The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

Entities:  

Keywords:  antibiotic resistance; antiseptic; chlorhexidine gluconate; decolonization; healthcare-associated infections

Mesh:

Substances:

Year:  2021        PMID: 32766819      PMCID: PMC8432606          DOI: 10.1093/cid/ciaa1103

Source DB:  PubMed          Journal:  Clin Infect Dis        ISSN: 1058-4838            Impact factor:   9.079


  89 in total

Review 1.  Bacterial resistance to disinfectants: present knowledge and future problems.

Authors:  A D Russell
Journal:  J Hosp Infect       Date:  1999-12       Impact factor: 3.926

2.  Efflux-related resistance to norfloxacin, dyes, and biocides in bloodstream isolates of Staphylococcus aureus.

Authors:  Carmen E DeMarco; Laurel A Cushing; Emmanuel Frempong-Manso; Susan M Seo; Tinevimbo A A Jaravaza; Glenn W Kaatz
Journal:  Antimicrob Agents Chemother       Date:  2007-06-18       Impact factor: 5.191

3.  Strategies to prevent central line-associated bloodstream infections in acute care hospitals: 2014 update.

Authors:  Jonas Marschall; Leonard A Mermel; Mohamad Fakih; Lynn Hadaway; Alexander Kallen; Naomi P O'Grady; Ann Marie Pettis; Mark E Rupp; Thomas Sandora; Lisa L Maragakis; Deborah S Yokoe
Journal:  Infect Control Hosp Epidemiol       Date:  2014-07       Impact factor: 3.254

4.  Chlorhexidine versus routine bathing to prevent multidrug-resistant organisms and all-cause bloodstream infections in general medical and surgical units (ABATE Infection trial): a cluster-randomised trial.

Authors:  Susan S Huang; Edward Septimus; Ken Kleinman; Julia Moody; Jason Hickok; Lauren Heim; Adrijana Gombosev; Taliser R Avery; Katherine Haffenreffer; Lauren Shimelman; Mary K Hayden; Robert A Weinstein; Caren Spencer-Smith; Rebecca E Kaganov; Michael V Murphy; Tyler Forehand; Julie Lankiewicz; Micaela H Coady; Lena Portillo; Jalpa Sarup-Patel; John A Jernigan; Jonathan B Perlin; Richard Platt
Journal:  Lancet       Date:  2019-03-05       Impact factor: 79.321

5.  Outbreak of Vancomycin-resistant Enterococcus faecium in Interventional Radiology: Detection Through Whole-genome Sequencing-based Surveillance.

Authors:  Alexander J Sundermann; Ahmed Babiker; Jane W Marsh; Kathleen A Shutt; Mustapha M Mustapha; Anthony W Pasculle; Chinelo Ezeonwuka; Melissa I Saul; Marissa P Pacey; Daria Van Tyne; Ashley M Ayres; Vaughn S Cooper; Graham M Snyder; Lee H Harrison
Journal:  Clin Infect Dis       Date:  2020-05-23       Impact factor: 9.079

6.  Klebsiella pneumoniae susceptibility to biocides and its association with cepA, qacΔE and qacE efflux pump genes and antibiotic resistance.

Authors:  A Abuzaid; A Hamouda; S G B Amyes
Journal:  J Hosp Infect       Date:  2012-04-11       Impact factor: 3.926

7.  Analysis of Multidrug-Resistant Organism Susceptibility to Chlorhexidine Under Usual Clinical Care.

Authors:  Jackson S Musuuza; Ajay K Sethi; Tonya J Roberts; Nasia Safdar
Journal:  Infect Control Hosp Epidemiol       Date:  2017-04-11       Impact factor: 3.254

8.  Yeasticidal activity of chemical disinfectants and antiseptics against Candida auris.

Authors:  G Moore; S Schelenz; A M Borman; E M Johnson; C S Brown
Journal:  J Hosp Infect       Date:  2017-09-01       Impact factor: 3.926

9.  Antibiotic resistance as an indicator of bacterial chlorhexidine susceptibility.

Authors:  S Kõljalg; P Naaber; M Mikelsaar
Journal:  J Hosp Infect       Date:  2002-06       Impact factor: 3.926

10.  Increased Usage of Antiseptics Is Associated with Reduced Susceptibility in Clinical Isolates of Staphylococcus aureus.

Authors:  Katherine Hardy; Katie Sunnucks; Hannah Gil; Sahida Shabir; Eleftheria Trampari; Peter Hawkey; Mark Webber
Journal:  mBio       Date:  2018-05-29       Impact factor: 7.867

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