Takanaga Niimi1, Mamoru Nanasato2, Mitsuo Sugimoto1, Hisatoshi Maeda3. 1. 1Department of Radiological Technology, Nagoya Daini Red Cross Hospital, 2-9 Myouken-cho, Showa-ku, Nagoya, 466-8650 Japan. 2. 2Cardiovascular Center, Nagoya Daini Red Cross Hospital, 2-9 Myouken-cho, Showa-ku, Nagoya, 466-8650 Japan. 3. 3Department of Radiological Technology, Nagoya University School of Health Sciences, 1-1-20 Daiko-minami, Higashi-ku, Nagoya, 461-8673 Japan.
Abstract
OBJECTIVE: A recently introduced single-photon emission computed tomography (SPECT), based on cadmium-zinc-telluride (CZT) detectors (D-SPECT), supports high energy resolution for cardiac imaging. Importantly, the high energy resolution may allow simultaneous dual-isotope (SDI) imaging (e.g., using Tc-99m and I-123). We quantitatively evaluated Tc-99m/I-123 SDI imaging by D-SPECT in comparison with conventional T1-201/I-123. MATERIALS AND METHODS: Energy resolution was measured as a percentage of the full width at half maximum (FWHM) for Tc-99m, I-123, and Tl-201. The impact of cross-talk and reconstructed image contrast were quantified by measuring the contrast-to-noise ratio (CNR), and the transmural defect contrast in the left ventricle wall (C TD) induced by a difference in energy, for combinations of Tc-99m/I-123 or Tl-201/I-123, using an RH-2 cardiac phantom. Corresponding measurement was also carried out in Anger SPECT (A-SPECT). RESULTS: The energy resolution of the D-SPECT system was 5.4%/5.1% for Tc-99m/I-123 and 5.4%/5.3% for Tl-201/I-123, which was approximately two times higher than the A-SPECT. No notable difference was confirmed in the CNRs of the two systems, but T1-201/I-123 showed overall higher value than Tc-99m/I-123. Compared to A-SPECT, C TD of D-SPECT significantly increased with both Tc-99m/I-123 and T1-201/I-123 (p < 0.05). In DSPECT, the combination of Tc-99m/I-123 had a slightly better C TD than T1-201/I-123. In addition, C TD of Tc-99m/I-123 was improved with scatter correction at both nuclides (p < 0.05), but in Tl-201/I-123, no significant improvement was confirmed in I-123 (p > 0.05). CONCLUSION: D-SPECT was considered to be capable of performing high-quality SDI imaging using Tc-99m/I-123.
OBJECTIVE: A recently introduced single-photon emission computed tomography (SPECT), based on cadmium-zinc-telluride (CZT) detectors (D-SPECT), supports high energy resolution for cardiac imaging. Importantly, the high energy resolution may allow simultaneous dual-isotope (SDI) imaging (e.g., using Tc-99m and I-123). We quantitatively evaluated Tc-99m/I-123 SDI imaging by D-SPECT in comparison with conventional T1-201/I-123. MATERIALS AND METHODS: Energy resolution was measured as a percentage of the full width at half maximum (FWHM) for Tc-99m, I-123, and Tl-201. The impact of cross-talk and reconstructed image contrast were quantified by measuring the contrast-to-noise ratio (CNR), and the transmural defect contrast in the left ventricle wall (C TD) induced by a difference in energy, for combinations of Tc-99m/I-123 or Tl-201/I-123, using an RH-2 cardiac phantom. Corresponding measurement was also carried out in Anger SPECT (A-SPECT). RESULTS: The energy resolution of the D-SPECT system was 5.4%/5.1% for Tc-99m/I-123 and 5.4%/5.3% for Tl-201/I-123, which was approximately two times higher than the A-SPECT. No notable difference was confirmed in the CNRs of the two systems, but T1-201/I-123 showed overall higher value than Tc-99m/I-123. Compared to A-SPECT, C TD of D-SPECT significantly increased with both Tc-99m/I-123 and T1-201/I-123 (p < 0.05). In DSPECT, the combination of Tc-99m/I-123 had a slightly better C TD than T1-201/I-123. In addition, C TD of Tc-99m/I-123 was improved with scatter correction at both nuclides (p < 0.05), but in Tl-201/I-123, no significant improvement was confirmed in I-123 (p > 0.05). CONCLUSION: D-SPECT was considered to be capable of performing high-quality SDI imaging using Tc-99m/I-123.
Entities:
Keywords:
CZT detector; Cardiac imaging; Energy resolution; Simultaneous dual-isotope SPECT
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