Three new pyoluteorin analogues, mindapyrroles A-C (1-3), were purified from Pseudomonas aeruginosa strain 1682U.R.0a.27, a gill-associated bacterium isolated from the tissue homogenate of the giant shipworm Kuphus polythalamius. Mindapyrroles B and C inhibit the growth of multiple pathogenic bacteria, with mindapyrrole B (2) showing the most potent antimicrobial activity and widest selectivity index over mammalian cells. Preliminary structure-activity relationship analysis showed that dimerization of the pyoluteorin moiety through a C-C linkage is detrimental to the antimicrobial activity, but addition of an aerugine unit in the methylene bridge is favorable for both the antimicrobial activity and selectivity index.
Three new pyoluteorin analogues, n class="Chemical">mindapyrroles A-C (1-3), were purified from Pseudomonas aeruginosa strain 1682U.R.0a.27, a gill-associated bacterium isolated from the tissue homogenate of the giant shipworm Kuphus polythalamius. Mindapyrroles B and C inhibit the growth of multiple pathogenic bacteria, with mindapyrrole B (2) showing the most potent antimicrobial activity and widest selectivity index over mammalian cells. Preliminary structure-activity relationship analysis showed that dimerization of the pyoluteorin moiety through a C-C linkage is detrimental to the antimicrobial activity, but addition of an aerugine unit in the methylene bridge is favorable for both the antimicrobial activity and selectivity index.
Authors: Nina M Haste; Chambers C Hughes; Dan N Tran; William Fenical; Paul R Jensen; Victor Nizet; Mary E Hensler Journal: Antimicrob Agents Chemother Date: 2011-04-18 Impact factor: 5.191
Authors: Zhenjian Lin; Rowena R Antemano; Ronald W Hughen; Ma Diarey B Tianero; Olivier Peraud; Margo G Haygood; Gisela P Concepcion; Baldomero M Olivera; Alan Light; Eric W Schmidt Journal: J Nat Prod Date: 2010-10-28 Impact factor: 4.050
Authors: Noel M Lacerna; Cydee Marie V Ramones; Jose Miguel D Robes; Myra Ruth D Picart; Jortan O Tun; Bailey W Miller; Margo G Haygood; Eric W Schmidt; Lilibeth A Salvador-Reyes; Gisela P Concepcion Journal: Mar Drugs Date: 2020-12-20 Impact factor: 5.118