| Literature DB >> 33419303 |
Noel M Lacerna1, Cydee Marie V Ramones1, Jose Miguel D Robes1, Myra Ruth D Picart1, Jortan O Tun1, Bailey W Miller2, Margo G Haygood2, Eric W Schmidt2, Lilibeth A Salvador-Reyes1, Gisela P Concepcion1.
Abstract
The bioactivity-guided purification of the culture broth of the shipworm endosymbiont Teredinibacter turnerae strain 991H.S.0a.06 yielded a new fatty acid, turneroic acid (1), and two previously described oxylipins (2-3). Turneroic acid (1) is an 18-carbon fatty acid decorated by a hydroxy group and an epoxide ring. Compounds 1-3 inhibited bacterial biofilm formation in Staphylococcus epidermidis, while only 3 showed antimicrobial activity against planktonic S. epidermidis. Comparison of the bioactivity of 1-3 with structurally related compounds indicated the importance of the epoxide moiety for selective and potent biofilm inhibition.Entities:
Keywords: Lyrodus; Staphylococcus epidermidis; Teredinibacter turnerae; anti-biofilm; oxylipins; shipworm
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Year: 2020 PMID： 33419303 PMCID： PMC7766104 DOI： 10.3390/md18120656
Source DB: PubMed Journal: Mar Drugs ISSN： 1660-3397 Impact factor: 5.118