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Literature DB >> 18205372

The marinopyrroles, antibiotics of an unprecedented structure class from a marine Streptomyces sp.

Chambers C Hughes¹, Alejandra Prieto-Davo, Paul R Jensen, William Fenical.

Abstract

Cultivation of an obligate marine Streptomyces strain has furnished the marinopyrroles A and B, densely halogenated, axially chiral metabolites that contain an uncommon bispyrrole structure. X-ray analysis of marinopyrrole B showed that the natural product exists as an atropo-enantiomer with the M-configuration. Though configurationally stable at room temperature, M-(-)-marinopyrrole A can be racemized at elevated temperatures to yield the non-natural P-(+)-atropo-enantiomer. The marinopyrroles possess potent antibiotic activities against methicillin-resistant Staphylococcus aureus.

Entities: Chemical Species

Mesh：

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Year: 2008 PMID： 18205372 PMCID： PMC2820876 DOI： 10.1021/ol702952n

Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005

9 in total

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