Literature DB >> 34564176

Marine Pyrrole Alkaloids.

Kevin Seipp1, Leander Geske1, Till Opatz1.   

Abstract

Nitrogen heterocycles are essential parts of the chemical machinery of life and often reveal intriguing structures. They are not only widespread in terrestrial habitats but can also frequently be found as natural products in the marine environment. This review highlights the important class of marine pyrrole alkaloids, well-known for their diverse biological activities. A broad overview of the marine pyrrole alkaloids with a focus on their isolation, biological activities, chemical synthesis, and derivatization covering the decade from 2010 to 2020 is provided. With relevant structural subclasses categorized, this review shall provide a clear and timely synopsis of this area.

Entities:  

Keywords:  alkaloids; bromopyrroles; marine natural products; nitrogen heterocycles; pyrrole-aminoimidazole alkaloids; pyrrole-imidazole alkaloids; pyrroles

Mesh:

Substances:

Year:  2021        PMID: 34564176      PMCID: PMC8471394          DOI: 10.3390/md19090514

Source DB:  PubMed          Journal:  Mar Drugs        ISSN: 1660-3397            Impact factor:   5.118


  245 in total

1.  Anti-infective discorhabdins from a deep-water alaskan sponge of the genus Latrunculia.

Authors:  Minkyun Na; Yuanqing Ding; Bin Wang; Babu L Tekwani; Raymond F Schinazi; Scott Franzblau; Michelle Kelly; Robert Stone; Xing-Cong Li; Daneel Ferreira; Mark T Hamann
Journal:  J Nat Prod       Date:  2010-03-26       Impact factor: 4.050

Review 2.  Muscarine, imidazole, oxazole and thiazole alkaloids.

Authors:  Zhong Jin
Journal:  Nat Prod Rep       Date:  2016-10-26       Impact factor: 13.423

3.  Isolation, Derivative Synthesis, and Structure-Activity Relationships of Antiparasitic Bromopyrrole Alkaloids from the Marine Sponge Tedania brasiliensis.

Authors:  Lizbeth L L Parra; Ariane F Bertonha; Ivan R M Severo; Anna C C Aguiar; Guilherme E de Souza; Glaucius Oliva; Rafael V C Guido; Nathalia Grazzia; Tábata R Costa; Danilo C Miguel; Fernanda R Gadelha; Antonio G Ferreira; Eduardo Hajdu; Daniel Romo; Roberto G S Berlinck
Journal:  J Nat Prod       Date:  2018-01-03       Impact factor: 4.050

4.  Total synthesis of (+/-)-marinopyrrole A and its library as potential antibiotic and anticancer agents.

Authors:  Chunwei Cheng; Lili Pan; Yi Chen; Hao Song; Yong Qin; Rongshi Li
Journal:  J Comb Chem       Date:  2010-07-12

Review 5.  Biosynthesis, asymmetric synthesis, and pharmacology, including cellular targets, of the pyrrole-2-aminoimidazole marine alkaloids.

Authors:  Ali Al-Mourabit; Manuel A Zancanella; Supriya Tilvi; Daniel Romo
Journal:  Nat Prod Rep       Date:  2011-05-09       Impact factor: 13.423

Review 6.  An overview on anti-tubulin agents for the treatment of lymphoma patients.

Authors:  Marilia Barreca; Anastasios Stathis; Paola Barraja; Francesco Bertoni
Journal:  Pharmacol Ther       Date:  2020-04-17       Impact factor: 12.310

7.  Molecular-targeted antitumor agents. 15. Neolamellarins from the marine sponge Dendrilla nigra inhibit hypoxia-inducible factor-1 activation and secreted vascular endothelial growth factor production in breast tumor cells.

Authors:  Rui Liu; Yang Liu; Yu-Dong Zhou; Dale G Nagle
Journal:  J Nat Prod       Date:  2007-10-25       Impact factor: 4.050

8.  Atkamine: a new pyrroloiminoquinone scaffold from the cold water Aleutian Islands Latrunculia sponge.

Authors:  Yike Zou; Mark T Hamann
Journal:  Org Lett       Date:  2013-03-08       Impact factor: 6.005

9.  Isohalitulin and haliclorensins B and C, three marine alkaloids from Haliclona tulearensis.

Authors:  Hagit Sorek; Amira Rudi; Maurice Aknin; Emile M Gaydou; Yoel Kashman
Journal:  J Nat Prod       Date:  2010-03-26       Impact factor: 4.050

10.  Transcriptomic analysis of marine endophytic fungi extract identifies highly enriched anti-fungal fractions targeting cancer pathways in HepG2 cell lines.

Authors:  Ethel Juliet Blessie; Wasco Wruck; Benaiah Annertey Abbey; Audrey Ncube; Nina Graffmann; Vincent Amarh; Patrick Kobina Arthur; James Adjaye
Journal:  BMC Genomics       Date:  2020-03-30       Impact factor: 3.969

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  3 in total

1.  Chemical Investigations of Differentially Oxidized Polycylic Pyrroles from Bipolaris Fungi: Synthetic Entry Into the Bipolamine Alkaloids.

Authors:  Jun Xuan; Paulo A Machicao; Karl T Haelsig; Thomas J Maimone
Journal:  Angew Chem Int Ed Engl       Date:  2022-08-08       Impact factor: 16.823

Review 2.  Structures and Biological Activities of Alkaloids Produced by Mushrooms, a Fungal Subgroup.

Authors:  Jesús G Zorrilla; Antonio Evidente
Journal:  Biomolecules       Date:  2022-07-24

Review 3.  Novel Alkaloids from Marine Actinobacteria: Discovery and Characterization.

Authors:  Anne-Sofie De Rop; Jeltien Rombaut; Thomas Willems; Marilyn De Graeve; Lynn Vanhaecke; Paco Hulpiau; Sofie L De Maeseneire; Maarten L De Mol; Wim K Soetaert
Journal:  Mar Drugs       Date:  2021-12-22       Impact factor: 5.118

  3 in total

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