| Literature DB >> 30499135 |
Anouar Fanidi1,2, Robert Carreras-Torres1, Tricia L Larose1,3, Jian-Min Yuan4,5, Victoria L Stevens6, Stephanie J Weinstein7, Demetrius Albanes7, Ross Prentice8, Mary Pettinger8, Qiuyin Cai9, William J Blot9,10, Alan A Arslan11, Anne Zeleniuch-Jacquotte12, Marjorie L McCullough6, Loic Le Marchand13, Lynne R Wilkens13, Christopher A Haiman14, Xuehong Zhang15, Meir J Stampfer15,16,17, Stephanie A Smith-Warner16,17, Edward Giovannucci15,16,17, Graham G Giles18,19, Allison M Hodge18,19, Gianluca Severi18,20,21, Mikael Johansson22, Kjell Grankvist23, Arnulf Langhammer24, Ben M Brumpton3, Renwei Wang4, Yu-Tang Gao25, Ulrika Ericson26,27, Stig E Bojesen26, Susanne M Arnold28, Woon-Puay Koh29, Xiao-Ou Shu9, Yong-Bing Xiang25, Honglan Li7, Wei Zheng9, Qing Lan7, Kala Visvanathan30, Judith Hoffman-Bolton30, Per M Ueland31,32, Øivind Midttun33, Neil E Caporaso7, Mark Purdue7, Neal D Freedman7, Julie E Buring16,34,35, I-Min Lee16,34, Howard D Sesso16,34,35, J Michael Gaziano34,35,36, Jonas Manjer37, Caroline L Relton38,39, Rayjean J Hung40, Chris I Amos41, Mattias Johansson1, Paul Brennan1.
Abstract
Vitamin B supplementation can have side effects for human health, including cancer risk. We aimed to elucidate the role of vitamin B12 in lung cancer etiology via direct measurements of pre-diagnostic circulating vitamin B12 concentrations in a nested case-control study, complemented with a Mendelian randomization (MR) approach in an independent case-control sample. We used pre-diagnostic biomarker data from 5183 case-control pairs nested within 20 prospective cohorts, and genetic data from 29,266 cases and 56,450 controls. Exposures included directly measured circulating vitamin B12 in pre-diagnostic blood samples from the nested case-control study, and 8 single nucleotide polymorphisms associated with vitamin B12 concentrations in the MR study. Our main outcome of interest was increased risk for lung cancer, overall and by histological subtype, per increase in circulating vitamin B12 concentrations. We found circulating vitamin B12 to be positively associated with overall lung cancer risk in a dose response fashion (odds ratio for a doubling in B12 [ORlog2B12 ] = 1.15, 95% confidence interval (95%CI) = 1.06-1.25). The MR analysis based on 8 genetic variants also indicated that genetically determined higher vitamin B12 concentrations were positively associated with overall lung cancer risk (OR per 150 pmol/L standard deviation increase in B12 [ORSD ] = 1.08, 95%CI = 1.00-1.16). Considering the consistency of these two independent and complementary analyses, these findings support the hypothesis that high vitamin B12 status increases the risk of lung cancer.Entities:
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Year: 2019 PMID： 30499135 PMCID： PMC6642017 DOI： 10.1002/ijc.32033
Source DB: PubMed Journal: Int J Cancer ISSN： 0020-7136 Impact factor: 7.396