| Literature DB >> 28604730 |
James D McKay1, Rayjean J Hung2, Younghun Han3, Xuchen Zong2, Robert Carreras-Torres1, David C Christiani4, Neil E Caporaso5, Mattias Johansson1, Xiangjun Xiao3, Yafang Li3, Jinyoung Byun3, Alison Dunning6, Karen A Pooley6, David C Qian3, Xuemei Ji3, Geoffrey Liu2, Maria N Timofeeva1, Stig E Bojesen7,8,9, Xifeng Wu10, Loic Le Marchand11, Demetrios Albanes5, Heike Bickeböller12, Melinda C Aldrich13, William S Bush14, Adonina Tardon15, Gad Rennert16, M Dawn Teare17, John K Field18, Lambertus A Kiemeney19, Philip Lazarus20, Aage Haugen21, Stephen Lam22, Matthew B Schabath23, Angeline S Andrew24, Hongbing Shen25, Yun-Chul Hong26, Jian-Min Yuan27, Pier Alberto Bertazzi28,29, Angela C Pesatori29, Yuanqing Ye10, Nancy Diao4, Li Su4, Ruyang Zhang4, Yonathan Brhane2, Natasha Leighl30, Jakob S Johansen31, Anders Mellemgaard31, Walid Saliba16, Christopher A Haiman32, Lynne R Wilkens11, Ana Fernandez-Somoano15, Guillermo Fernandez-Tardon15, Henricus F M van der Heijden19, Jin Hee Kim33, Juncheng Dai25, Zhibin Hu25, Michael P A Davies18, Michael W Marcus18, Hans Brunnström34, Jonas Manjer35, Olle Melander35, David C Muller36, Kim Overvad37, Antonia Trichopoulou38, Rosario Tumino39, Jennifer A Doherty24,40,41,42, Matt P Barnett40, Chu Chen40, Gary E Goodman43, Angela Cox44, Fiona Taylor44, Penella Woll44, Irene Brüske45, H-Erich Wichmann45,46,47, Judith Manz48, Thomas R Muley49,50, Angela Risch48,49,50,51,52, Albert Rosenberger12, Kjell Grankvist53, Mikael Johansson54, Frances A Shepherd30, Ming-Sound Tsao30, Susanne M Arnold55, Eric B Haura56, Ciprian Bolca57, Ivana Holcatova58, Vladimir Janout59, Milica Kontic60,61, Jolanta Lissowska62, Anush Mukeria63, Simona Ognjanovic64, Tadeusz M Orlowski65, Ghislaine Scelo1, Beata Swiatkowska66, David Zaridze63, Per Bakke67, Vidar Skaug21, Shanbeh Zienolddiny21, Eric J Duell68, Lesley M Butler27, Woon-Puay Koh69, Yu-Tang Gao70, Richard S Houlston71, John McLaughlin72, Victoria L Stevens73, Philippe Joubert74, Maxime Lamontagne74, David C Nickle75, Ma'en Obeidat76, Wim Timens77, Bin Zhu5, Lei Song5, Linda Kachuri2, María Soler Artigas78,79, Martin D Tobin78,79, Louise V Wain78,79, Thorunn Rafnar80, Thorgeir E Thorgeirsson80, Gunnar W Reginsson80, Kari Stefansson80, Dana B Hancock81, Laura J Bierut82, Margaret R Spitz83, Nathan C Gaddis84, Sharon M Lutz85, Fangyi Gu5, Eric O Johnson86, Ahsan Kamal3, Claudio Pikielny3, Dakai Zhu3, Sara Lindströem87, Xia Jiang88, Rachel F Tyndale89,90, Georgia Chenevix-Trench91, Jonathan Beesley91, Yohan Bossé74,92, Stephen Chanock5, Paul Brennan1, Maria Teresa Landi5, Christopher I Amos3.
Abstract
Although several lung cancer susceptibility loci have been identified, much of the heritability for lung cancer remains unexplained. Here 14,803 cases and 12,262 controls of European descent were genotyped on the OncoArray and combined with existing data for an aggregated genome-wide association study (GWAS) analysis of lung cancer in 29,266 cases and 56,450 controls. We identified 18 susceptibility loci achieving genome-wide significance, including 10 new loci. The new loci highlight the striking heterogeneity in genetic susceptibility across the histological subtypes of lung cancer, with four loci associated with lung cancer overall and six loci associated with lung adenocarcinoma. Gene expression quantitative trait locus (eQTL) analysis in 1,425 normal lung tissue samples highlights RNASET2, SECISBP2L and NRG1 as candidate genes. Other loci include genes such as a cholinergic nicotinic receptor, CHRNA2, and the telomere-related genes OFBC1 and RTEL1. Further exploration of the target genes will continue to provide new insights into the etiology of lung cancer.Entities:
Mesh：
Year: 2017 PMID： 28604730 PMCID： PMC5510465 DOI： 10.1038/ng.3892
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330