Hung N Luu1,2, Renwei Wang1, Aizhen Jin3, Woon-Puay Koh3,4, Jian-Min Yuan1,2. 1. Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center. 2. Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. 3. Health Services and Systems Research, Duke-NUS Medical School Singapore. 4. Saw Swee Hock School of Public Health, National University of Singapore, Singapore.
Abstract
BACKGROUND: Since previous epidemiological studies reported inconsistent associations between dietary vitamin B12 intake and lung cancer risk, more studies are warranted to clarify this association in different populations. METHODS: The association between dietary B12 intake and lung cancer risk was examined in the Singapore Chinese Health Study, an ongoing prospective cohort study of 63 257 Singaporean Chinese men and women, 45-74 years of age at enrollment during 1993-1998 and were followed up for incidence of lung cancer for up to 25 years. Dietary vitamin B12 intake was derived from a validated food frequency questionnaire. Cox proportional hazard regression method was used to estimate hazard ratio and 95% confidence interval (CI) of lung cancer associated with dietary vitamin B12 intake with adjustment for multiple potential confounders. RESULTS: After a mean follow-up of 17.64 years, 2001 study participants developed lung cancer. High levels of vitamin B12 intake were associated with significantly increased risk of lung cancer (Ptrend = 0.03). Compared with the lowest quintile, hazard ratios (95% CIs) of lung cancer for quintile 2, 3, 4, and 5 of vitamin B12 intake were 1.09 (0.95-1.25), 1.11 (0.96-1.28), 1.11 (0.97-1.29) and 1.18 (1.03-1.35), respectively. This positive association was more apparent in men than in women, in adenocarcinoma patients, or in participants with equal or less than 2 years follow-up than those with longer duration of follow-up. CONCLUSION: Higher intake of dietary vitamin B12 was associated with increased risk of lung cancer. This highlights the potential harmful effect of vitamin B12 supplementation for lung cancer.
BACKGROUND: Since previous epidemiological studies reported inconsistent associations between dietary vitamin B12 intake and lung cancer risk, more studies are warranted to clarify this association in different populations. METHODS: The association between dietary B12 intake and lung cancer risk was examined in the Singapore Chinese Health Study, an ongoing prospective cohort study of 63 257 Singaporean Chinese men and women, 45-74 years of age at enrollment during 1993-1998 and were followed up for incidence of lung cancer for up to 25 years. Dietary vitamin B12 intake was derived from a validated food frequency questionnaire. Cox proportional hazard regression method was used to estimate hazard ratio and 95% confidence interval (CI) of lung cancer associated with dietary vitamin B12 intake with adjustment for multiple potential confounders. RESULTS: After a mean follow-up of 17.64 years, 2001 study participants developed lung cancer. High levels of vitamin B12 intake were associated with significantly increased risk of lung cancer (Ptrend = 0.03). Compared with the lowest quintile, hazard ratios (95% CIs) of lung cancer for quintile 2, 3, 4, and 5 of vitamin B12 intake were 1.09 (0.95-1.25), 1.11 (0.96-1.28), 1.11 (0.97-1.29) and 1.18 (1.03-1.35), respectively. This positive association was more apparent in men than in women, in adenocarcinoma patients, or in participants with equal or less than 2 years follow-up than those with longer duration of follow-up. CONCLUSION: Higher intake of dietary vitamin B12 was associated with increased risk of lung cancer. This highlights the potential harmful effect of vitamin B12 supplementation for lung cancer.
Authors: Yumie Takata; Xiao-Ou Shu; Maciej S Buchowski; Heather M Munro; Wanqing Wen; Mark D Steinwandel; Margaret K Hargreaves; William J Blot; Qiuyin Cai Journal: Eur J Nutr Date: 2019-03-05 Impact factor: 5.614
Authors: Marta Ebbing; Kaare Harald Bønaa; Ottar Nygård; Egil Arnesen; Per Magne Ueland; Jan Erik Nordrehaug; Knut Rasmussen; Inger Njølstad; Helga Refsum; Dennis W Nilsen; Aage Tverdal; Klaus Meyer; Stein Emil Vollset Journal: JAMA Date: 2009-11-18 Impact factor: 56.272
Authors: A Seow; C Y Shi; F L Chung; D Jiao; J H Hankin; H P Lee; G A Coetzee; M C Yu Journal: Cancer Epidemiol Biomarkers Prev Date: 1998-09 Impact factor: 4.254
Authors: Anouar Fanidi; Robert Carreras-Torres; Tricia L Larose; Jian-Min Yuan; Victoria L Stevens; Stephanie J Weinstein; Demetrius Albanes; Ross Prentice; Mary Pettinger; Qiuyin Cai; William J Blot; Alan A Arslan; Anne Zeleniuch-Jacquotte; Marjorie L McCullough; Loic Le Marchand; Lynne R Wilkens; Christopher A Haiman; Xuehong Zhang; Meir J Stampfer; Stephanie A Smith-Warner; Edward Giovannucci; Graham G Giles; Allison M Hodge; Gianluca Severi; Mikael Johansson; Kjell Grankvist; Arnulf Langhammer; Ben M Brumpton; Renwei Wang; Yu-Tang Gao; Ulrika Ericson; Stig E Bojesen; Susanne M Arnold; Woon-Puay Koh; Xiao-Ou Shu; Yong-Bing Xiang; Honglan Li; Wei Zheng; Qing Lan; Kala Visvanathan; Judith Hoffman-Bolton; Per M Ueland; Øivind Midttun; Neil E Caporaso; Mark Purdue; Neal D Freedman; Julie E Buring; I-Min Lee; Howard D Sesso; J Michael Gaziano; Jonas Manjer; Caroline L Relton; Rayjean J Hung; Chris I Amos; Mattias Johansson; Paul Brennan Journal: Int J Cancer Date: 2019-01-15 Impact factor: 7.396