Muhammad Ramish Ashraf1, Petr Bruza1, Venkat Krishnaswamy1,2, David J Gladstone1,3,4, Brian W Pogue1,2. 1. Thayer School of Engineering, Dartmouth College, Hanover, NH, 03755, USA. 2. DoseOptics LLC, Lebanon, NH, 03766, USA. 3. Department of Medicine, Geisel School of Medicine, Dartmouth College Hanover, Hanover, NH, 03755, USA. 4. Norris Cotton Cancer Center, Dartmouth-Hitchcock Medical Center, Lebanon, NH, 03756, USA.
Abstract
PURPOSE: CCD cameras are employed to image scintillation and Cherenkov radiation in external beam radiotherapy. This is achieved by gating the camera to the linear accelerator (Linac) output. A direct output signal line from the linac is not always accessible and even in cases where such a signal is accessible, a physical wire connected to the output port can potentially alter Linac performance through electrical feedback. A scintillating detector for stray radiation inside the Linac room was developed to remotely time-gate to linac pulses for camera-based dosimetry. METHODS: A scintillator coupled silicon photomultiplier detector was optimized and systematically tested for location sensitivity and for use with both x rays and electron beams, at different energies and field sizes. Cherenkov radiation emitted due to static photon beams was captured using the remote trigger and compared to the images captured using a wired trigger. The issue of false-positive event detection, due to additional neutron activated products with high energy beams, was addressed. RESULTS: The designed circuit provided voltage >2.5 V even for distances up to 3 m from the isocenter with a 6 MV, 5 × 5 cm beam, using a Ø3 × 20 mm3 Bi4 Ge3 O12 (BGO) crystal. With a larger scintillator size, the detector could be placed even beyond 3 m distance. False-positive triggering was reduced by a coincidence detection scheme. Negligible fluctuations were observed in time-gated imaging of Cherenkov intensity emitted from a water phantom, when comparing directly connected vs this remote triggering approach. CONCLUSION: The remote detector provides untethered synchronization to linac pulses. It is especially useful for remote Cherenkov imaging or remote scintillator dosimetry imaging during radiotherapeutic procedures when a direct line signal is not accessible.
PURPOSE: CCD cameras are employed to image scintillation and Cherenkov radiation in external beam radiotherapy. This is achieved by gating the camera to the linear accelerator (Linac) output. A direct output signal line from the linac is not always accessible and even in cases where such a signal is accessible, a physical wire connected to the output port can potentially alter Linac performance through electrical feedback. A scintillating detector for stray radiation inside the Linac room was developed to remotely time-gate to linac pulses for camera-based dosimetry. METHODS: A scintillator coupled silicon photomultiplier detector was optimized and systematically tested for location sensitivity and for use with both x rays and electron beams, at different energies and field sizes. Cherenkov radiation emitted due to static photon beams was captured using the remote trigger and compared to the images captured using a wired trigger. The issue of false-positive event detection, due to additional neutron activated products with high energy beams, was addressed. RESULTS: The designed circuit provided voltage >2.5 V even for distances up to 3 m from the isocenter with a 6 MV, 5 × 5 cm beam, using a Ø3 × 20 mm3 Bi4 Ge3 O12 (BGO) crystal. With a larger scintillator size, the detector could be placed even beyond 3 m distance. False-positive triggering was reduced by a coincidence detection scheme. Negligible fluctuations were observed in time-gated imaging of Cherenkov intensity emitted from a water phantom, when comparing directly connected vs this remote triggering approach. CONCLUSION: The remote detector provides untethered synchronization to linac pulses. It is especially useful for remote Cherenkov imaging or remote scintillator dosimetry imaging during radiotherapeutic procedures when a direct line signal is not accessible.
Authors: Adam K Glaser; Rongxiao Zhang; Jacqueline M Andreozzi; David J Gladstone; Brian W Pogue Journal: Phys Med Biol Date: 2015-08-13 Impact factor: 3.609
Authors: Muhammad Ramish Ashraf; Petr Bruza; Brian W Pogue; Nathan Nelson; Benjamin B Williams; Lesley A Jarvis; David J Gladstone Journal: Med Phys Date: 2019-10-04 Impact factor: 4.071
Authors: Jacqueline M Andreozzi; Petr Brůža; Jochen Cammin; Brian W Pogue; David J Gladstone; Olga Green Journal: Med Phys Date: 2019-12-25 Impact factor: 4.071
Authors: Daniel A Alexander; Irwin I Tendler; Petr Bruza; Xu Cao; Philip E Schaner; Bethany S Marshall; Lesley A Jarvis; David J Gladstone; Brian W Pogue Journal: Phys Med Biol Date: 2019-07-18 Impact factor: 3.609
Authors: Rachael Hachadorian; J Cedar Farwell; Petr Bruza; Michael Jermyn; David J Gladstone; Brian W Pogue; Lesley A Jarvis Journal: Radiother Oncol Date: 2021-05-01 Impact factor: 6.901
Authors: Irwin I Tendler; Petr Bruza; Michael Jermyn; Jennifer Soter; Gregory Sharp; Benjamin Williams; Lesley A Jarvis; Brian Pogue; David J Gladstone Journal: J Appl Clin Med Phys Date: 2020-04-19 Impact factor: 2.102