Literature DB >> 3045821

Discrimination between glutaminyl-tRNA synthetase and seryl-tRNA synthetase involves nucleotides in the acceptor helix of tRNA.

M J Rogers1, D Söll.   

Abstract

Analysis of the in vivo amber suppressor activity of mutants derived from two Escherichia coli serine tRNAs shows that substitution of 2 base pairs in the acceptor helix changes a serine suppressor tRNA to an efficient glutamine acceptor. Determination of the amino acid inserted in vivo into protein by this tRNA shows that these changes reduce the tRNA recognition by seryl-tRNA synthetase while increasing that of glutaminyl-tRNA synthetase. This implies that misaminoacylation in vivo is dependent on the competition by different synthetases for the tRNA. In addition, the "translational efficiency" of tRNA is an integral part in observing misaminoacylation in vivo.

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Year:  1988        PMID： 3045821      PMCID： PMC282030          DOI： 10.1073/pnas.85.18.6627

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  34 in total

Review 1.  tRNA, suppression, and the code.

Authors:  E J Murgola
Journal:  Annu Rev Genet       Date:  1985       Impact factor: 16.830

2.  Biochemical and physical characterization of an unmodified yeast phenylalanine transfer RNA transcribed in vitro.

Authors:  J R Sampson; O C Uhlenbeck
Journal:  Proc Natl Acad Sci U S A       Date:  1988-02       Impact factor: 11.205

3.  Is there a discriminator site in transfer RNA?

Authors:  D M Crothers; T Seno; G Söll
Journal:  Proc Natl Acad Sci U S A       Date:  1972-10       Impact factor: 11.205

4.  The translational efficiency of tRNA is a property of the anticodon arm.

Authors:  M Yarus; S Cline; L Raftery; P Wier; D Bradley
Journal:  J Biol Chem       Date:  1986-08-15       Impact factor: 5.157

Review 5.  Compilation of tRNA sequences and sequences of tRNA genes.

Authors:  M Sprinzl; T Hartmann; F Meissner; J Moll; T Vorderwülbecke
Journal:  Nucleic Acids Res       Date:  1987       Impact factor: 16.971

6.  A plasmid cloning vehicle allowing a positive selection for inserted fragments.

Authors:  T M Roberts; S L Swanberg; A Poteete; G Riedel; K Backman
Journal:  Gene       Date:  1980-12       Impact factor: 3.688

7.  In vitro conversion of a methionine to a glutamine-acceptor tRNA.

Authors:  L H Schulman; H Pelka
Journal:  Biochemistry       Date:  1985-12-03       Impact factor: 3.162

8.  Escherichia coli formylmethionine tRNA: mutations in GGGCCC sequence conserved in anticodon stem of initiator tRNAs affect initiation of protein synthesis and conformation of anticodon loop.

Authors:  B L Seong; U L RajBhandary
Journal:  Proc Natl Acad Sci U S A       Date:  1987-01       Impact factor: 11.205

9.  Escherichia coli supH suppressor: temperature-sensitive missense suppression caused by an anticodon change in tRNASer2.

Authors:  S Thorbjarnardóttir; H Uemura; T Dingermann; T Rafnar; S Thorsteinsdóttir; D Söll; G Eggertsson
Journal:  J Bacteriol       Date:  1985-01       Impact factor: 3.490

10.  Systematic alterations in the anticodon arm make tRNA(Glu)-Suoc a more efficient suppressor.

Authors:  L A Raftery; M Yarus
Journal:  EMBO J       Date:  1987-05       Impact factor: 11.598
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  26 in total

1.  An engineered class I transfer RNA with a class II tertiary fold.

Authors:  T A Nissan; B Oliphant; J J Perona
Journal:  RNA       Date:  1999-03       Impact factor: 4.942

Review 2.  The accuracy of aminoacylation--ensuring the fidelity of the genetic code.

Authors:  D Söll
Journal:  Experientia       Date:  1990-12-01

3.  Eight base changes are sufficient to convert a leucine-inserting tRNA into a serine-inserting tRNA.

Authors:  J Normanly; T Ollick; J Abelson
Journal:  Proc Natl Acad Sci U S A       Date:  1992-06-15       Impact factor: 11.205

4.  Binding of human glutaminyl-tRNA synthetase to a specific site of its mRNA.

Authors:  B Schray; R Knippers
Journal:  Nucleic Acids Res       Date:  1991-10-11       Impact factor: 16.971

5.  Occurrence and functional compatibility within Enterobacteriaceae of a tRNA species which inserts selenocysteine into protein.

Authors:  J Heider; W Leinfelder; A Böck
Journal:  Nucleic Acids Res       Date:  1989-04-11       Impact factor: 16.971

6.  Acceptor end binding domain interactions ensure correct aminoacylation of transfer RNA.

Authors:  I Weygand-Durasević; E Schwob; D Söll
Journal:  Proc Natl Acad Sci U S A       Date:  1993-03-01       Impact factor: 11.205

7.  Isolation and characterization of the gene coding for Escherichia coli arginyl-tRNA synthetase.

Authors:  G Eriani; G Dirheimer; J Gangloff
Journal:  Nucleic Acids Res       Date:  1989-07-25       Impact factor: 16.971

8.  Functional communication in the recognition of tRNA by Escherichia coli glutaminyl-tRNA synthetase.

Authors:  M J Rogers; T Adachi; H Inokuchi; D Söll
Journal:  Proc Natl Acad Sci U S A       Date:  1994-01-04       Impact factor: 11.205

Review 9.  Functions of the gene products of Escherichia coli.

Authors:  M Riley
Journal:  Microbiol Rev       Date:  1993-12

10.  Competition of aminoacyl-tRNA synthetases for tRNA ensures the accuracy of aminoacylation.

Authors:  J M Sherman; M J Rogers; D Söll
Journal:  Nucleic Acids Res       Date:  1992-06-11       Impact factor: 16.971
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