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Literature DB >> 3027365

Retrovirus integration and chromatin structure: Moloney murine leukemia proviral integration sites map near DNase I-hypersensitive sites.

H Rohdewohld, H Weiher, W Reik, R Jaenisch, M Breindl.

Abstract

The chromatin conformation of mouse genome regions containing Moloney murine leukemia proviral intergration sites in two Mov mouse strains and randomly selected integration sites in virus-infected mouse 3T3 fibroblasts was analyzed. All integrations have occurred into chromosomal regions containing several DNase-hypersensitive sites, and invariably the proviral integration sites map within a few hundred base pairs of a DNase-hypersensitive site. The probability that this close association between proviral integration sites and DNase-hypersensitive sites was due to chance was calculated to be extremely low (2 X 10(-4]. Because the proviral integrations analyzed were not selected for an altered phenotype, our results suggest that DNase-hypersensitive regions are preferred targets for retrovirus integration.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 1987 PMID： 3027365 PMCID： PMC253954 DOI： 10.1128/JVI.61.2.336-343.1987

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

34 in total

1. Sequence-specific insertion of the Drosophila transposable genetic element 17.6.

Authors: S Inouye; S Yuki; K Saigo
Journal: Nature Date: 1984 Jul 26-Aug 1 Impact factor: 49.962

2. Mutant immunoglobulin genes have repetitive DNA elements inserted into their intervening sequences.

Authors: R G Hawley; M J Shulman; H Murialdo; D M Gibson; N Hozumi
Journal: Proc Natl Acad Sci U S A Date: 1982-12 Impact factor: 11.205

3. Alteration of c-myc chromatin structure by avian leukosis virus integration.

Authors: W Schubach; M Groudine
Journal: Nature Date: 1984 Feb 23-29 Impact factor: 49.962

4. A transposable element inserted just 5' to a Drosophila glue protein gene alters gene expression and chromatin structure.

Authors: W McGinnis; A W Shermoen; S K Beckendorf
Journal: Cell Date: 1983-08 Impact factor: 41.582

5. Embryonic lethal mutation in mice induced by retrovirus insertion into the alpha 1(I) collagen gene.

Authors: A Schnieke; K Harbers; R Jaenisch
Journal: Nature Date: 1983 Jul 28-Aug 3 Impact factor: 49.962

6. Insertion of retrovirus into the first intron of alpha 1(I) collagen gene to embryonic lethal mutation in mice.

Authors: K Harbers; M Kuehn; H Delius; R Jaenisch
Journal: Proc Natl Acad Sci U S A Date: 1984-03 Impact factor: 11.205

7. Preferential integration of yeast transposable element Ty into a promoter region.

Authors: H Eibel; P Philippsen
Journal: Nature Date: 1984 Jan 26-Feb 1 Impact factor: 49.962

8. Insertion of a movable genetic element, 297, into the T-A-T-A box for the H3 histone gene in Drosophila melanogaster.

Authors: H Ikenaga; K Saigo
Journal: Proc Natl Acad Sci U S A Date: 1982-07 Impact factor: 11.205

9. Cloning of two genetically transmitted Moloney leukemia proviral genomes: correlation between biological activity of the cloned DNA and viral genome activation in the animal.

Authors: I Chumakov; H Stuhlmann; K Harbers; R Jaenisch
Journal: J Virol Date: 1982-06 Impact factor: 5.103

10. High-frequency homologous recombination between duplicate chromosomal immunoglobulin mu heavy-chain constant regions.

Authors: M D Baker
Journal: Mol Cell Biol Date: 1989-12 Impact factor: 4.272

Retrovirus integration and chromatin structure: Moloney murine leukemia proviral integration sites map near DNase I-hypersensitive sites.

1. Sequence-specific insertion of the Drosophila transposable genetic element 17.6.

2. Mutant immunoglobulin genes have repetitive DNA elements inserted into their intervening sequences.

3. Alteration of c-myc chromatin structure by avian leukosis virus integration.

4. A transposable element inserted just 5' to a Drosophila glue protein gene alters gene expression and chromatin structure.

5. Embryonic lethal mutation in mice induced by retrovirus insertion into the alpha 1(I) collagen gene.

6. Insertion of retrovirus into the first intron of alpha 1(I) collagen gene to embryonic lethal mutation in mice.

7. Preferential integration of yeast transposable element Ty into a promoter region.

8. Insertion of a movable genetic element, 297, into the T-A-T-A box for the H3 histone gene in Drosophila melanogaster.

9. Cloning of two genetically transmitted Moloney leukemia proviral genomes: correlation between biological activity of the cloned DNA and viral genome activation in the animal.

10. Conformation of promoter DNA: fine mapping of S1-hypersensitive sites.

1. A large-scale insertional mutagenesis screen in zebrafish.

2. Isolation and analysis of retroviral integration targets by solo long terminal repeat inverse PCR.

3. Relationship between retroviral DNA integration and gene expression.

4. Nonrandom integration of retroviral DNA in vitro: effect of CpG methylation.

5. HIV-1 promotor insertion revealed by selective detection of chimeric provirus-host gene transcripts.

6. Host sequences flanking the HIV provirus.

7. Gammaretroviral vector integration occurs overwhelmingly within and near DNase hypersensitive sites.

8. A novel, plasmid-based system for studying gene rearrangements in mammalian cells.

9. Analysis of yeast retrotransposon Ty insertions at the CAN1 locus.

10. High-frequency homologous recombination between duplicate chromosomal immunoglobulin mu heavy-chain constant regions.