Literature DB >> 2235486

Host sequences flanking the HIV provirus.

K A Vincent1, D York-Higgins, M Quiroga, P O Brown.   

Abstract

A conserved property of retroviral proviruses is the presence of a direct repeat in the host DNA immediately flanking the viral sequence; each virus generates a repeat with a characteristic length. By sequencing the viral/host DNA junctions from five HIV-1 proviral clones, we have confirmed that integration of HIV results in the generation of a five basepair direct repeat. A target sequence in uninfected host DNA was analyzed to establish that the five basepair sequence flanking the provirus was present only once prior to integration. Of the five proviruses examined, two were found to have integrated in known repetitive sequence elements of the human genome; one in a Line-1 element and a second in satellite DNA.

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Year:  1990        PMID： 2235486      PMCID： PMC332403          DOI： 10.1093/nar/18.20.6045

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  24 in total

1.  Characterization of long terminal repeat sequences of HTLV-III.

Authors:  B Starcich; L Ratner; S F Josephs; T Okamoto; R C Gallo; F Wong-Staal
Journal:  Science       Date:  1985-02-01       Impact factor: 47.728

2.  Proviruses of avian sarcoma virus are terminally redundant, co-extensive with unintegrated linear DNA and integrated at many sites.

Authors:  S H Hughes; P R Shank; D H Spector; H J Kung; J M Bishop; H E Varmus; P K Vogt; M L Breitman
Journal:  Cell       Date:  1978-12       Impact factor: 41.582

3.  No apparent nucleotide sequence specificity in cellular DNA juxtaposed to retrovirus proviruses.

Authors:  K Shimotohno; H M Temin
Journal:  Proc Natl Acad Sci U S A       Date:  1980-12       Impact factor: 11.205

4.  Nucleotide sequences of integrated Moloney sarcoma provirus long terminal repeats and their host and viral junctions.

Authors:  R Dhar; W L McClements; L W Enquist; G F Vande Woude
Journal:  Proc Natl Acad Sci U S A       Date:  1980-07       Impact factor: 11.205

5.  A comprehensive set of sequence analysis programs for the VAX.

Authors:  J Devereux; P Haeberli; O Smithies
Journal:  Nucleic Acids Res       Date:  1984-01-11       Impact factor: 16.971

6.  Human satellite I sequences include a male specific 2.47 kb tandemly repeated unit containing one Alu family member per repeat.

Authors:  M Frommer; J Prosser; P C Vincent
Journal:  Nucleic Acids Res       Date:  1984-03-26       Impact factor: 16.971

7.  Human immunodeficiency virus integration in a cell-free system.

Authors:  V Ellison; H Abrams; T Roe; J Lifson; P Brown
Journal:  J Virol       Date:  1990-06       Impact factor: 5.103

8.  Molecular characterization of human T-cell leukemia (lymphotropic) virus type III in the acquired immune deficiency syndrome.

Authors:  G M Shaw; B H Hahn; S K Arya; J E Groopman; R C Gallo; F Wong-Staal
Journal:  Science       Date:  1984-12-07       Impact factor: 47.728

9.  Molecular cloning of AIDS-associated retrovirus.

Authors:  P A Luciw; S J Potter; K Steimer; D Dina; J A Levy
Journal:  Nature       Date:  1984 Dec 20-1985 Jan 2       Impact factor: 49.962

10.  A Rous sarcoma virus provirus is flanked by short direct repeats of a cellular DNA sequence present in only one copy prior to integration.

Authors:  S H Hughes; A Mutschler; J M Bishop; H E Varmus
Journal:  Proc Natl Acad Sci U S A       Date:  1981-07       Impact factor: 11.205
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  28 in total

1.  New nucleotide sequence data on the EMBL File Server.

Authors: 
Journal:  Nucleic Acids Res       Date:  1991-01-11       Impact factor: 16.971

2.  Biochemical analysis of HIV-1 integrase variants resistant to strand transfer inhibitors.

Authors:  Ira B Dicker; Brian Terry; Zeyu Lin; Zhufang Li; Sagarika Bollini; Himadri K Samanta; Volodymyr Gali; Michael A Walker; Mark R Krystal
Journal:  J Biol Chem       Date:  2008-06-24       Impact factor: 5.157

3.  Chromosome structure and human immunodeficiency virus type 1 cDNA integration: centromeric alphoid repeats are a disfavored target.

Authors:  S Carteau; C Hoffmann; F Bushman
Journal:  J Virol       Date:  1998-05       Impact factor: 5.103

4.  Tethering human immunodeficiency virus type 1 preintegration complexes to target DNA promotes integration at nearby sites.

Authors:  F D Bushman; M D Miller
Journal:  J Virol       Date:  1997-01       Impact factor: 5.103

Review 5.  Multifaceted HIV integrase functionalities and therapeutic strategies for their inhibition.

Authors:  Alan N Engelman
Journal:  J Biol Chem       Date:  2019-08-29       Impact factor: 5.157

6.  Site-specific hydrolysis and alcoholysis of human immunodeficiency virus DNA termini mediated by the viral integrase protein.

Authors:  C Vink; E Yeheskiely; G A van der Marel; J H van Boom; R H Plasterk
Journal:  Nucleic Acids Res       Date:  1991-12-25       Impact factor: 16.971

7.  Quantitative analysis of HIV-1 preintegration complexes.

Authors:  Alan Engelman; Ilker Oztop; Nick Vandegraaff; Nidhanapati K Raghavendra
Journal:  Methods       Date:  2009-02-20       Impact factor: 3.608

8.  Juxtaposition of two viral DNA ends in a bimolecular disintegration reaction mediated by multimers of human immunodeficiency virus type 1 or murine leukemia virus integrase.

Authors:  S A Chow; P O Brown
Journal:  J Virol       Date:  1994-12       Impact factor: 5.103

9.  Human immunodeficiency virus type 1 may preferentially integrate into chromatin occupied by L1Hs repetitive elements.

Authors:  S W Stevens; J D Griffith
Journal:  Proc Natl Acad Sci U S A       Date:  1994-06-07       Impact factor: 11.205

10.  Fidelity of target site duplication and sequence preference during integration of xenotropic murine leukemia virus-related virus.

Authors:  Sanggu Kim; Alice Rusmevichientong; Beihua Dong; Roland Remenyi; Robert H Silverman; Samson A Chow
Journal:  PLoS One       Date:  2010-04-20       Impact factor: 3.240
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