Literature DB >> 6296832

Mutant immunoglobulin genes have repetitive DNA elements inserted into their intervening sequences.

R G Hawley, M J Shulman, H Murialdo, D M Gibson, N Hozumi.   

Abstract

The kappa light chain genes from two mutant hybridoma cell lines defective in kappa light chain synthesis were isolated and compared to the wild-type kappa light chain gene. In each case, the mutant kappa light chain genes were found to contain repetitive DNA elements in their intervening sequences that were not present in the intervening sequences of the wild-type kappa light chain gene. These elements were found to be related to the genes of intracisternal A particles. These results suggest that the decreased production of kappa light chain in the mutant cell lines is due to the presence of the intracisternal A particle-related genes.

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Year:  1982        PMID： 6296832      PMCID： PMC347352          DOI： 10.1073/pnas.79.23.7425

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  44 in total

1.  Recombinant DNA clones constructed from immunoglobulin kappa light chain messenger RNA.

Authors:  R Wall; M Gilmore-Hebert; R Higuchi; M Komaromy; G Paddock; J Strommer; W Salser
Journal:  Nucleic Acids Res       Date:  1978-09       Impact factor: 16.971

2.  Characterization of a mouse DNA clone containing an immunoglobulin variable region gene.

Authors:  N Hozumi; C Brack; V Pirrotta; R Lenhard-Schuller; S Tonegawa
Journal:  Nucleic Acids Res       Date:  1978-06       Impact factor: 16.971

3.  Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose.

Authors:  P S Thomas
Journal:  Proc Natl Acad Sci U S A       Date:  1980-09       Impact factor: 11.205

4.  Activation of trypanosome surface glycoprotein genes involves a duplication-transposition leading to an altered 3' end.

Authors:  A Bernards; L H Van der Ploeg; A C Frasch; P Borst; J C Boothroyd; S Coleman; G A Cross
Journal:  Cell       Date:  1981-12       Impact factor: 41.582

5.  Gene duplication and transposition linked to antigenic variation in Trypanosoma brucei.

Authors:  E Pays; N Van Meirvenne; D Le Ray; M Steinert
Journal:  Proc Natl Acad Sci U S A       Date:  1981-05       Impact factor: 11.205

6.  Retroviruses as mutagens: insertion and excision of a nontransforming provirus alter expression of a resident transforming provirus.

Authors:  H E Varmus; N Quintrell; S Ortiz
Journal:  Cell       Date:  1981-07       Impact factor: 41.582

7.  Rearrangement of immunoglobulin gamma 1-chain gene and mechanism for heavy-chain class switch.

Authors:  T Kataoka; T Kawakami; N Takahashi; T Honjo
Journal:  Proc Natl Acad Sci U S A       Date:  1980-02       Impact factor: 11.205

8.  Rearrangement of immunoglobulin genes.

Authors:  R Wilson; J Miller; U Storb
Journal:  Biochemistry       Date:  1979-10-30       Impact factor: 3.162

9.  The structure of transposable yeast mating type loci.

Authors:  K A Nasmyth; K Tatchell
Journal:  Cell       Date:  1980-03       Impact factor: 41.582

10.  Dilute (d) coat colour mutation of DBA/2J mice is associated with the site of integration of an ecotropic MuLV genome.

Authors:  N A Jenkins; N G Copeland; B A Taylor; B K Lee
Journal:  Nature       Date:  1981-10-01       Impact factor: 49.962
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  58 in total

Review 1.  Modular transposition and the dynamical structure of eukaryote regulatory evolution.

Authors:  C C King
Journal:  Genetica       Date:  1992       Impact factor: 1.082

2.  Tissue and strain-specific patterns of endogenous proviral hypomethylation analyzed by two-dimensional gel electrophoresis.

Authors:  J A Mietz; E L Kuff
Journal:  Proc Natl Acad Sci U S A       Date:  1990-03       Impact factor: 11.205

3.  Identification and characterization of novel human endogenous retroviral sequences prefentially expressed in undifferentiated embryonal carcinoma cells.

Authors:  G La Mantia; D Maglione; G Pengue; A Di Cristofano; A Simeone; L Lanfrancone; L Lania
Journal:  Nucleic Acids Res       Date:  1991-04-11       Impact factor: 16.971

4.  Functional heterogeneity of a large family of human LTR-like promoters and enhancers.

Authors:  A Feuchter; D Mager
Journal:  Nucleic Acids Res       Date:  1990-03-11       Impact factor: 16.971

5.  Functional modularity in the SP6 kappa promoter.

Authors:  E Högbom; A C Magnusson; T Leanderson
Journal:  Nucleic Acids Res       Date:  1991-08-25       Impact factor: 16.971

6.  Expression of immunoglobulin-T-cell receptor chimeric molecules as functional receptors with antibody-type specificity.

Authors:  G Gross; T Waks; Z Eshhar
Journal:  Proc Natl Acad Sci U S A       Date:  1989-12       Impact factor: 11.205

7.  High-frequency homologous recombination between duplicate chromosomal immunoglobulin mu heavy-chain constant regions.

Authors:  M D Baker
Journal:  Mol Cell Biol       Date:  1989-12       Impact factor: 4.272

8.  Molecular cloning and long terminal repeat sequences of intracisternal A-particle genes in Mus caroli.

Authors:  M Ono; H Kitasato; H Ohishi; Y Motobayashi-Nakajima
Journal:  J Virol       Date:  1984-05       Impact factor: 5.103

9.  Insertion of retrovirus into the first intron of alpha 1(I) collagen gene to embryonic lethal mutation in mice.

Authors:  K Harbers; M Kuehn; H Delius; R Jaenisch
Journal:  Proc Natl Acad Sci U S A       Date:  1984-03       Impact factor: 11.205

10.  PANG, a gene encoding a neuronal glycoprotein, is ectopically activated by intracisternal A-type particle long terminal repeats in murine plasmacytomas.

Authors:  M A Connelly; R C Grady; J F Mushinski; K B Marcu
Journal:  Proc Natl Acad Sci U S A       Date:  1994-02-15       Impact factor: 11.205
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