Literature DB >> 3025832

Cloning and characterization of the high-affinity cAMP phosphodiesterase of Saccharomyces cerevisiae.

P Sass, J Field, J Nikawa, T Toda, M Wigler.   

Abstract

A gene, PDE2, has been cloned from the yeast Saccharomyces cerevisiae that, when present in high copy, reverses the phenotypic effects of RAS2Val19, a mutant form of the RAS2 gene that renders yeast cells sensitive to heat shock and starvation. It has previously been shown that the RAS proteins are potent activators of yeast adenylate cyclase. We report here that PDE2 encodes a high-affinity cAMP phosphodiesterase that shares sequence homology with animal cell phosphodiesterases. These results therefore imply that the effects of RAS2Val19 are mediated through its changes in cAMP concentration.

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Year:  1986        PMID： 3025832      PMCID： PMC387126          DOI： 10.1073/pnas.83.24.9303

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  33 in total

1.  Cytidine 3':5'-monophosphate phosphodiesterase in mammalian tissues. Occurrence and biological involvement.

Authors:  J F Kuo; N L Brackett; M Shoji; J Tse
Journal:  J Biol Chem       Date:  1978-04-25       Impact factor: 5.157

2.  Multiple cyclic nucleotide phosphodiesterase activities from rat brain.

Authors:  W J Thompson; M M Appleman
Journal:  Biochemistry       Date:  1971-01-19       Impact factor: 3.162

3.  Transformation in yeast: development of a hybrid cloning vector and isolation of the CAN1 gene.

Authors:  J R Broach; J N Strathern; J B Hicks
Journal:  Gene       Date:  1979-12       Impact factor: 3.688

4.  Pattern recognition in nucleic acid sequences. I. A general method for finding local homologies and symmetries.

Authors:  W B Goad; M I Kanehisa
Journal:  Nucleic Acids Res       Date:  1982-01-11       Impact factor: 16.971

5.  Isolation of genes by complementation in yeast: molecular cloning of a cell-cycle gene.

Authors:  K A Nasmyth; S I Reed
Journal:  Proc Natl Acad Sci U S A       Date:  1980-04       Impact factor: 11.205

6.  Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mp18 and pUC19 vectors.

Authors:  C Yanisch-Perron; J Vieira; J Messing
Journal:  Gene       Date:  1985       Impact factor: 3.688

7.  Purification and properties of bovine brain calmodulin-dependent cyclic nucleotide phosphodiesterase.

Authors:  R K Sharma; T H Wang; E Wirch; J H Wang
Journal:  J Biol Chem       Date:  1980-06-25       Impact factor: 5.157

8.  High-frequency transformation of yeast: autonomous replication of hybrid DNA molecules.

Authors:  K Struhl; D T Stinchcomb; S Scherer; R W Davis
Journal:  Proc Natl Acad Sci U S A       Date:  1979-03       Impact factor: 11.205

9.  DNA sequencing with chain-terminating inhibitors.

Authors:  F Sanger; S Nicklen; A R Coulson
Journal:  Proc Natl Acad Sci U S A       Date:  1977-12       Impact factor: 11.205

10.  Purification and characterization of a cyclic GMP-stimulated cyclic nucleotide phosphodiesterase from bovine tissues.

Authors:  T J Martins; M C Mumby; J A Beavo
Journal:  J Biol Chem       Date:  1982-02-25       Impact factor: 5.157
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  128 in total

1.  Saccharomyces cerevisiae Ras/cAMP pathway controls post-diauxic shift element-dependent transcription through the zinc finger protein Gis1.

Authors:  I Pedruzzi; N Bürckert; P Egger; C De Virgilio
Journal:  EMBO J       Date:  2000-06-01       Impact factor: 11.598

2.  Antagonistic interactions between the cAMP-dependent protein kinase and Tor signaling pathways modulate cell growth in Saccharomyces cerevisiae.

Authors:  Vidhya Ramachandran; Paul K Herman
Journal:  Genetics       Date:  2010-11-15       Impact factor: 4.562

3.  Temporal and spatial regulation of gene expression during asexual development of Neurospora crassa.

Authors:  Charles J Greenwald; Takao Kasuga; N Louise Glass; Brian D Shaw; Daniel J Ebbole; Heather H Wilkinson
Journal:  Genetics       Date:  2010-09-27       Impact factor: 4.562

4.  SRA5 encodes the low-Km cyclic AMP phosphodiesterase of Saccharomyces cerevisiae.

Authors:  R B Wilson; K Tatchell
Journal:  Mol Cell Biol       Date:  1988-01       Impact factor: 4.272

5.  Cloning and characterization of the low-affinity cyclic AMP phosphodiesterase gene of Saccharomyces cerevisiae.

Authors:  J Nikawa; P Sass; M Wigler
Journal:  Mol Cell Biol       Date:  1987-10       Impact factor: 4.272

6.  Overexpression of RPI1, a novel inhibitor of the yeast Ras-cyclic AMP pathway, down-regulates normal but not mutationally activated ras function.

Authors:  J H Kim; S Powers
Journal:  Mol Cell Biol       Date:  1991-08       Impact factor: 4.272

7.  MSI1, a negative regulator of the RAS-cAMP pathway in Saccharomyces cerevisiae.

Authors:  R Ruggieri; K Tanaka; M Nakafuku; Y Kaziro; A Toh-e; K Matsumoto
Journal:  Proc Natl Acad Sci U S A       Date:  1989-11       Impact factor: 11.205

8.  Ras membrane targeting is essential for glucose signaling but not for viability in yeast.

Authors:  S Bhattacharya; L Chen; J R Broach; S Powers
Journal:  Proc Natl Acad Sci U S A       Date:  1995-03-28       Impact factor: 11.205

9.  Expression of three mammalian cDNAs that interfere with RAS function in Saccharomyces cerevisiae.

Authors:  J Colicelli; C Nicolette; C Birchmeier; L Rodgers; M Riggs; M Wigler
Journal:  Proc Natl Acad Sci U S A       Date:  1991-04-01       Impact factor: 11.205

10.  Involvement of distinct G-proteins, Gpa2 and Ras, in glucose- and intracellular acidification-induced cAMP signalling in the yeast Saccharomyces cerevisiae.

Authors:  S Colombo; P Ma; L Cauwenberg; J Winderickx; M Crauwels; A Teunissen; D Nauwelaers; J H de Winde; M F Gorwa; D Colavizza; J M Thevelein
Journal:  EMBO J       Date:  1998-06-15       Impact factor: 11.598
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