Literature DB >> 2824992

Cloning and characterization of the low-affinity cyclic AMP phosphodiesterase gene of Saccharomyces cerevisiae.

J Nikawa1, P Sass, M Wigler.   

Abstract

Saccharomyces cerevisiae contains two genes which encode cyclic AMP (cAMP) phosphodiesterase. We previously isolated and characterized PDE2, which encodes a high-affinity cAMP phosphodiesterase. We have now isolated the PDE1 gene of S. cerevisiae, which encodes a low-affinity cAMP phosphodiesterase. These two genes represent highly divergent branches in the evolution of phosphodiesterases. High-copy-number plasmids containing either PDE1 or PDE2 can reverse the growth arrest defects of yeast cells carrying the RAS2(Val-19) mutation. PDE1 and PDE2 appear to account for the aggregate cAMP phosphodiesterase activity of S. cerevisiae. Disruption of both PDE genes results in a phenotype which resembles that induced by the RAS2(Val-19) mutation. pde1- pde2- ras1- ras2- cells are viable.

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Year:  1987        PMID： 2824992      PMCID： PMC368017          DOI： 10.1128/mcb.7.10.3629-3636.1987

Source DB:  PubMed          Journal:  Mol Cell Biol        ISSN： 0270-7306            Impact factor:   4.272


  38 in total

1.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

2.  Construction of improved M13 vectors using oligodeoxynucleotide-directed mutagenesis.

Authors:  J Norrander; T Kempe; J Messing
Journal:  Gene       Date:  1983-12       Impact factor: 3.688

3.  Characterization of a cyclic nucleotide phosphodiesterase-deficient mutant in yeast.

Authors:  I Uno; K Matsumoto; T Ishikawa
Journal:  J Biol Chem       Date:  1983-03-25       Impact factor: 5.157

4.  Buffer gradient gels and 35S label as an aid to rapid DNA sequence determination.

Authors:  M D Biggin; T J Gibson; G F Hong
Journal:  Proc Natl Acad Sci U S A       Date:  1983-07       Impact factor: 11.205

5.  Genetic analysis of yeast RAS1 and RAS2 genes.

Authors:  T Kataoka; S Powers; C McGill; O Fasano; J Strathern; J Broach; M Wigler
Journal:  Cell       Date:  1984-06       Impact factor: 41.582

6.  The zinc-containing high Km cyclic nucleotide phosphodiesterase of bakers' yeast.

Authors:  J Londesborough; K Suoranta
Journal:  J Biol Chem       Date:  1983-03-10       Impact factor: 5.157

7.  Nucleotide sequence of the yeast plasmid.

Authors:  J L Hartley; J E Donelson
Journal:  Nature       Date:  1980-08-28       Impact factor: 49.962

8.  Genes in S. cerevisiae encoding proteins with domains homologous to the mammalian ras proteins.

Authors:  S Powers; T Kataoka; O Fasano; M Goldfarb; J Strathern; J Broach; M Wigler
Journal:  Cell       Date:  1984-03       Impact factor: 41.582

9.  Transformation of intact yeast cells treated with alkali cations.

Authors:  H Ito; Y Fukuda; K Murata; A Kimura
Journal:  J Bacteriol       Date:  1983-01       Impact factor: 3.490

10.  ras-Related gene sequences identified and isolated from Saccharomyces cerevisiae.

Authors:  D DeFeo-Jones; E M Scolnick; R Koller; R Dhar
Journal:  Nature       Date:  1983 Dec 15-21       Impact factor: 49.962
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  78 in total

Review 1.  cAMP signaling in Dictyostelium. Complexity of cAMP synthesis, degradation and detection.

Authors:  Shweta Saran; Marcel E Meima; Elisa Alvarez-Curto; Karin E Weening; Daniel E Rozen; Pauline Schaap
Journal:  J Muscle Res Cell Motil       Date:  2002       Impact factor: 2.698

2.  Overexpression of RPI1, a novel inhibitor of the yeast Ras-cyclic AMP pathway, down-regulates normal but not mutationally activated ras function.

Authors:  J H Kim; S Powers
Journal:  Mol Cell Biol       Date:  1991-08       Impact factor: 4.272

3.  The transcription factor Swi4 is target for PKA regulation of cell size at the G1 to S transition in Saccharomyces cerevisiae.

Authors:  Loredana Amigoni; Sonia Colombo; Fiorella Belotti; Lilia Alberghina; Enzo Martegani
Journal:  Cell Cycle       Date:  2015-06-05       Impact factor: 4.534

4.  A novel Ras inhibitor, Eri1, engages yeast Ras at the endoplasmic reticulum.

Authors:  Andrew K Sobering; Martin J Romeo; Heather A Vay; David E Levin
Journal:  Mol Cell Biol       Date:  2003-07       Impact factor: 4.272

5.  Saccharomyces cerevisiae IRE2/HAC1 is involved in IRE1-mediated KAR2 expression.

Authors:  J Nikawa; M Akiyoshi; S Hirata; T Fukuda
Journal:  Nucleic Acids Res       Date:  1996-11-01       Impact factor: 16.971

6.  Expression of three mammalian cDNAs that interfere with RAS function in Saccharomyces cerevisiae.

Authors:  J Colicelli; C Nicolette; C Birchmeier; L Rodgers; M Riggs; M Wigler
Journal:  Proc Natl Acad Sci U S A       Date:  1991-04-01       Impact factor: 11.205

7.  Involvement of distinct G-proteins, Gpa2 and Ras, in glucose- and intracellular acidification-induced cAMP signalling in the yeast Saccharomyces cerevisiae.

Authors:  S Colombo; P Ma; L Cauwenberg; J Winderickx; M Crauwels; A Teunissen; D Nauwelaers; J H de Winde; M F Gorwa; D Colavizza; J M Thevelein
Journal:  EMBO J       Date:  1998-06-15       Impact factor: 11.598

Review 8.  Life in the midst of scarcity: adaptations to nutrient availability in Saccharomyces cerevisiae.

Authors:  Bart Smets; Ruben Ghillebert; Pepijn De Snijder; Matteo Binda; Erwin Swinnen; Claudio De Virgilio; Joris Winderickx
Journal:  Curr Genet       Date:  2010-02       Impact factor: 3.886

9.  Morphogenesis signaling components influence cell cycle regulation by cyclin dependent kinase.

Authors:  Brian Td Tobe; Ana A Kitazono; Jacqueline S Garcia; Renee A Gerber; Brooke J Bevis; John S Choy; Daniel Chasman; Stephen J Kron
Journal:  Cell Div       Date:  2009-07-01       Impact factor: 5.130

10.  Adaptation to high-salt stress in Saccharomyces cerevisiae is regulated by Ca2+/calmodulin-dependent phosphoprotein phosphatase (calcineurin) and cAMP-dependent protein kinase.

Authors:  D Hirata; S Harada; H Namba; T Miyakawa
Journal:  Mol Gen Genet       Date:  1995-11-27
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