Literature DB >> 3024106

The mRNA and RNA-copy pseudogenes encoding TM30nm, a human cytoskeletal tropomyosin.

A R MacLeod, C Houlker, F C Reinach, K Talbot.   

Abstract

We have determined the sequence of a 2.5 kb mRNA in human fibroblasts encoding a 248 amino acid cytoskeletal tropomyosin. The protein product of this mRNA is TM30nm, one of five tropomyosin-like proteins in human fibroblasts. The structural gene encoding this mRNA can also produce a 1.3 kb mRNA encoding a 285 amino acid skeletal muscle alpha-tropomyosin by tissue-specific alternative mRNA splicing. However, the multiple RNA-copy pseudogenes of this gene family are derived largely if not exclusively from transcripts processed according to the pattern observed in non-muscle cells.

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Year:  1986        PMID： 3024106      PMCID： PMC311868          DOI： 10.1093/nar/14.21.8413

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  29 in total

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Authors:  R A Laskey; A D Mills
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5.  Novel bacteriophage lambda cloning vector.

Authors:  J Karn; S Brenner; L Barnett; G Cesareni
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7.  Analytical techniques for cell fractions. XXII. Two-dimensional analysis of serum and tissue proteins: multiple gradient-slab gel electrophoresis.

Authors:  N L Anderson; N G Anderson
Journal:  Anal Biochem       Date:  1978-04       Impact factor: 3.365

8.  Construction of bacterial plasmids containing sequences complementary to chicken alpha-tropomyosin mRNA.

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9.  A new computer method for the storage and manipulation of DNA gel reading data.

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Journal:  Nucleic Acids Res       Date:  1980-08-25       Impact factor: 16.971

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  15 in total

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2.  Alternative splicing of a human alpha-tropomyosin muscle-specific exon: identification of determining sequences.

Authors:  I R Graham; M Hamshere; I C Eperon
Journal:  Mol Cell Biol       Date:  1992-09       Impact factor: 4.272

3.  Avian cardiac tropomyosin gene produces tissue-specific isoforms through alternative RNA splicing.

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4.  Transformation-related expression of a low-molecular-mass tropomyosin isoform TM5/TM30nm in transformed rat fibroblastic cell lines.

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Journal:  J Cancer Res Clin Oncol       Date:  1997       Impact factor: 4.553

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Authors:  D F Wieczorek; C W Smith; B Nadal-Ginard
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6.  Identification of human epidermal differentiation complex (EDC)-encoded genes by subtractive hybridization of entire YACs to a gridded keratinocyte cDNA library.

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7.  Human hTM alpha gene: expression in muscle and nonmuscle tissue.

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8.  Cloning and characterization of a cDNA encoding transformation-sensitive tropomyosin isoform 3 from tumorigenic human fibroblasts.

Authors:  C S Lin; J Leavitt
Journal:  Mol Cell Biol       Date:  1988-01       Impact factor: 4.272

9.  Avian tropomyosin gene expression.

Authors:  G J Lindquester; J E Flach; D E Fleenor; K H Hickman; R B Devlin
Journal:  Nucleic Acids Res       Date:  1989-03-11       Impact factor: 16.971

10.  Evolution of tropomyosin functional domains: differential splicing and genomic constraints.

Authors:  S Colote; J S Widada; C Ferraz; F Bonhomme; J Marti; J P Liautard
Journal:  J Mol Evol       Date:  1988       Impact factor: 2.395
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