Literature DB >> 9222299

Transformation-related expression of a low-molecular-mass tropomyosin isoform TM5/TM30nm in transformed rat fibroblastic cell lines.

K Miyado1, M Sato, S Taniguchi.   

Abstract

We cloned a full-length rat TM5/TM30nm cDNA. Using this cDNA as a probe, we demonstrated that expression of TM5/TM30nm mRNA was higher in the tumorigenic rat fibroblastic cell lines SR-3Y1-2 and fos-SR-3Y1-202 than in the normal cell line 3Y1. High expression of TM5/TM30nm protein in SR-3Y1-2 and fos-SR-3Y1-202 cells was also detected by Western blot analysis using anti-TM5/TM30nm antiserum. In addition, the cellular localization of this protein differed between 3Y1 cells and tumorigenic ones. These findings suggest that TM5/TM30nm is involved in malignant transformation of rat fibroblastic cells.

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Year:  1997        PMID： 9222299     DOI： 10.1007/bf01438309

Source DB:  PubMed          Journal:  J Cancer Res Clin Oncol        ISSN： 0171-5216            Impact factor:   4.553


  26 in total

1.  High invasiveness associated with augmentation of motility in a fos-transferred highly metastatic rat 3Y1 cell line.

Authors:  S Taniguchi; M Tatsuka; K Nakamatsu; M Inoue; H Sadano; H Okazaki; H Iwamoto; T Baba
Journal:  Cancer Res       Date:  1989-12-01       Impact factor: 12.701

2.  The amino terminus of muscle tropomyosin is a major determinant for function.

Authors:  Y J Cho; J Liu; S E Hitchcock-DeGregori
Journal:  J Biol Chem       Date:  1990-01-05       Impact factor: 5.157

3.  Multiple tropomyosin polypeptides in chicken embryo fibroblasts: differential repression of transcription by Rous sarcoma virus transformation.

Authors:  M Hendricks; H Weintraub
Journal:  Mol Cell Biol       Date:  1984-09       Impact factor: 4.272

4.  Differential expression of tropomyosin forms in the microfilaments isolated from normal and transformed rat cultured cells.

Authors:  F Matsumura; J J Lin; S Yamashiro-Matsumura; G P Thomas; W C Topp
Journal:  J Biol Chem       Date:  1983-11-25       Impact factor: 5.157

5.  Purification and characterization of multiple isoforms of tropomyosin from rat cultured cells.

Authors:  F Matsumura; S Yamashiro-Matsumura
Journal:  J Biol Chem       Date:  1985-11-05       Impact factor: 5.157

6.  Suppression of synthesis and utilization of tropomyosin in mouse and rat fibroblasts by transforming growth factor alpha: a pathway in oncogene action.

Authors:  H L Cooper; B Bhattacharya; R H Bassin; D S Salomon
Journal:  Cancer Res       Date:  1987-08-15       Impact factor: 12.701

7.  Human fibroblast tropomyosin isoforms: characterization of cDNA clones and analysis of tropomyosin isoform expression in human tissues and in normal and transformed cells.

Authors:  R E Novy; J L Lin; C S Lin; J J Lin
Journal:  Cell Motil Cytoskeleton       Date:  1993

8.  Metastatic potential prediction by a visual grading system of cell motility: prospective validation in the Dunning R-3327 prostatic adenocarcinoma model.

Authors:  J L Mohler; A W Partin; J T Isaacs; D S Coffey
Journal:  Cancer Res       Date:  1988-08-01       Impact factor: 12.701

9.  Alteration in expression of smooth muscle alpha-actin associated with transformation of rat 3Y1 cells.

Authors:  M Okamoto-Inoue; S Taniguchi; H Sadano; T Kawano; G Kimura; G Gabbiani; T Baba
Journal:  J Cell Sci       Date:  1990-08       Impact factor: 5.285

10.  Tropomyosin isoforms in chicken embryo fibroblasts: purification, characterization, and changes in Rous sarcoma virus-transformed cells.

Authors:  J J Lin; D M Helfman; S H Hughes; C S Chou
Journal:  J Cell Biol       Date:  1985-03       Impact factor: 10.539
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  5 in total

Review 1.  Interior decoration: tropomyosin in actin dynamics and cell migration.

Authors:  Justin G Lees; Cuc T T Bach; Geraldine M O'Neill
Journal:  Cell Adh Migr       Date:  2011-03-01       Impact factor: 3.405

2.  Tetratricopeptide repeat domain 9A is an interacting protein for tropomyosin Tm5NM-1.

Authors:  Shenglan Cao; Gay Hui Ho; Valerie C L Lin
Journal:  BMC Cancer       Date:  2008-08-12       Impact factor: 4.430

3.  Developmental Profiling of Tropomyosin Expression in Mouse Brain Reveals Tpm4.2 as the Major Post-synaptic Tropomyosin in the Mature Brain.

Authors:  Alexandra K Suchowerska; Sandra Fok; Holly Stefen; Peter W Gunning; Edna C Hardeman; John Power; Thomas Fath
Journal:  Front Cell Neurosci       Date:  2017-12-22       Impact factor: 5.505

4.  Calponin h1 suppresses tumor growth of Src-induced transformed 3Y1 cells in association with a decrease in angiogenesis.

Authors:  Miwako Kaneko; Michiko Takeoka; Misae Oguchi; Yoko Koganehira; Hiroshi Murata; Takashi Ehara; Minoru Tozuka; Toshiaki Saida; Shun'ichiro Taniguchi
Journal:  Jpn J Cancer Res       Date:  2002-08

5.  The actin cytoskeleton as a sensor and mediator of apoptosis.

Authors:  Melissa Desouza; Peter W Gunning; Justine R Stehn
Journal:  Bioarchitecture       Date:  2012-05-01
  5 in total

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